Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: effects of adrenalectomy and cholecystokinin.

Abstract:

:In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr postinfusion period. The cumulative food intake at the end of 4 hr of NPY infusion was enhanced in a dose-related fashion between 0, 117 and 470 pmol/hr; at 1175 pmol/hr food intake plateaued. In addition, the latency to initiate feeding response decreased in a dose-related fashion and feeding occurred in discrete (35-45) episodes during the 4 hr infusion period. Further, the total time feeding and local eating rate (g/min) increased significantly in response to the higher rates of NPY infusion. Concurrent infusion of cholecystokinin (CCK) at either equimolar or 2.5 x NPY dose, affected neither the NPY-induced cumulative food intake nor any other parameter of feeding behavior. On the other hand, cumulative food intake was significantly decreased in adrenalectomized rats in response to NPY infusion (470 pmol/hr); a response due primarily to a marked suppression in some, and almost complete cessation of food consumption in other rats during the second 2 hr period of NPY infusion. These studies show that continuous central infusion of NPY can produce sustained, intermittent feeding behavior and adrenalectomy significantly curtailed the duration of NPY effectiveness.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Peptides

journal_title

Peptides

authors

Kalra SP,Dube MG,Kalra PS

doi

10.1016/0196-9781(88)90112-x

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

723-8

issue

4

eissn

0196-9781

issn

1873-5169

pii

0196-9781(88)90112-X

journal_volume

9

pub_type

杂志文章

相关文献

PEPTIDES文献大全
  • Localization and opiate receptor binding of enkephalin, CCK and ACTH/beta-endorphin in the rat central nervous system.

    abstract::We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/0196-9781(81)90050-4

    authors: Stengaard-Pedersen K,Larsson LI

    更新日期:1981-01-01 00:00:00

  • Immunohistochemical demonstration of [D-Ala2]deltorphin-I in amacrine cells of rat retina.

    abstract::In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(94)90169-4

    authors: Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

    更新日期:1994-01-01 00:00:00

  • Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. III. Inactivation of CCK-8 by a phosphoramidon-sensitive endopeptidase.

    abstract::Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(84)90098-6

    authors: Deschodt-Lanckman M,Koulischer D,Przedborski S,Lauwereys M

    更新日期:1984-05-01 00:00:00

  • Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene.

    abstract::Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2018.06.010

    authors: Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

    更新日期:2018-09-01 00:00:00

  • Molecular cloning, over expression, and activity studies of a peptidic HIV-1 protease inhibitor: designed synthetic gene to functional recombinant peptide.

    abstract::The aspartic protease inhibitor (ATBI) purified from a Bacillus sp. is a potent inhibitor of several proteases including recombinant HIV-1 protease, pepsin, and fungal aspartic protease. In this study, we report the cloning, and over expression of a synthetic gene coding for ATBI in Escherichia coli and establish a pu...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2009.09.034

    authors: Vathipadiekal V,Umasankar PK,Patole MS,Rao M

    更新日期:2010-01-01 00:00:00

  • Roles of different peptide fragments derived from proadrenomedullin in the regulation of vascular tone in isolated rat aorta.

    abstract::The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pre...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(03)00109-8

    authors: Li J,Ren Y,Dong X,Zhong G,Wu S,Tang C

    更新日期:2003-04-01 00:00:00

  • Urocortins and the regulation of gastrointestinal motor function and visceral pain.

    abstract::Urocortin (Ucn) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related peptides recently characterized in mammals. Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands. They also have a distinct pattern of distribution, both in the ...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2004.05.025

    authors: Martinez V,Wang L,Million M,Rivier J,Taché Y

    更新日期:2004-10-01 00:00:00

  • Hydra head activator-like immunoreactivity in human brain astrocytomas grade III-IV and the surrounding brain tissue.

    abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(90)90081-f

    authors: Ekman R,Salford L,Brun A,Larsson I

    更新日期:1990-03-01 00:00:00

  • Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome.

    abstract::Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(93)90138-7

    authors: Berntson GG,Zipf WB,O'Dorisio TM,Hoffman JA,Chance RE

    更新日期:1993-05-01 00:00:00

  • Bombesin increases dopamine function in rat brain areas.

    abstract::Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(84)90081-0

    authors: Widerlöv E,Mueller RA,Frye GD,Breese GR

    更新日期:1984-05-01 00:00:00

  • Melanin-concentrating hormone in the human brain.

    abstract::The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(93)90158-d

    authors: Mouri T,Takahashi K,Kawauchi H,Sone M,Totsune K,Murakami O,Itoi K,Ohneda M,Sasano H,Sasano N

    更新日期:1993-05-01 00:00:00

  • The female reproductive system of the kissing bug, Rhodnius prolixus: arrangements of muscles, distribution and myoactivity of two endogenous FMRFamide-like peptides.

    abstract::Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.04.003

    authors: Sedra L,Lange AB

    更新日期:2014-03-01 00:00:00

  • Improvement of lipoxygenase inhibition by octapeptides.

    abstract::The beta-casein-derived octapeptide RINKKIEK is a noncompetitive inhibitor of soybean lipoxygenase (LOX). To investigate the molecular determinants for the enzyme-peptide interaction, a peptide library containing substitutional analogs of RINKKIEK was prepared by SPOT synthesis and analyzed for interaction with fluore...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2007.09.018

    authors: Schurink M,van Berkel WJ,Wichers HJ,Boeriu CG

    更新日期:2007-12-01 00:00:00

  • Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiae.

    abstract::A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2006.09.019

    authors: Garczynski SF,Crim JW,Brown MR

    更新日期:2007-01-01 00:00:00

  • Apelin attenuates TGF-β1-induced epithelial to mesenchymal transition via activation of PKC-ε in human renal tubular epithelial cells.

    abstract::Epithelial to mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells transition to a mesenchymal phenotype, has been implicated in the pathogenesis of renal fibrosis. Apelin, a bioactive peptide, has recently been recognized to protect against renal profibrotic activity, but the underlyi...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2017.08.006

    authors: Wang LY,Diao ZL,Zheng JF,Wu YR,Zhang QD,Liu WH

    更新日期:2017-10-01 00:00:00

  • Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation.

    abstract::Neuropeptide S (NPS) produces several biological actions by activating a formerly orphan GPCR, now named NPS receptor (NPSR). It has been previously demonstrated that NPS stimulates murine leukocyte chemotaxis in vitro. In the present study we investigated the ability of NPS, in comparison with the proinflammatory pep...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.10.013

    authors: Filaferro M,Novi C,Ruggieri V,Genedani S,Alboni S,Malagoli D,Caló G,Guerrini R,Vitale G

    更新日期:2013-01-01 00:00:00

  • Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study.

    abstract::This study sought to determine the serum levels of chemerin in gastric cancer patients and healthy subjects and to investigate the biological effect of chemerin on gastric cancer cells. Serum chemerin level of 36 gastric cancer patients and 40 healthy subjects was measured by enzyme-linked immunosorbent assay. AGS and...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.10.009

    authors: Wang C,Wu WK,Liu X,To KF,Chen GG,Yu J,Ng EK

    更新日期:2014-01-01 00:00:00

  • Thermoregulatory, behavioral and seizure modulatory effects of AVP in the gerbil.

    abstract::Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(83)90070-0

    authors: Lee RJ,Lomax P

    更新日期:1983-11-01 00:00:00

  • Identification of ostrich and chicken cholecystokinin cDNA and intestinal peptides.

    abstract::The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(00)00276-x

    authors: Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

    更新日期:2000-09-01 00:00:00

  • Cholinergic and VIPergic effects on thyroid hormone secretion in the mouse.

    abstract::The thyroid gland is known to harbor cholinergic and VIPergic nerves. In the present study, the influences of cholinergic stimulation by carbachol, cholinergic blockade by methylatropine and stimulation with various VIP sequences on basal, TSH-induced and VIP-induced thyroid hormone section were investigated in vivo i...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(85)90157-3

    authors: Ahrén B

    更新日期:1985-07-01 00:00:00

  • Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins.

    abstract::Short synthetic peptides corresponding to sequences of complementarity-determining regions (CDRs) from different immunoglobulin families have been shown to induce antimicrobial, antiviral and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). Presently, we studied the in vitr...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2014.06.007

    authors: Figueiredo CR,Matsuo AL,Massaoka MH,Polonelli L,Travassos LR

    更新日期:2014-09-01 00:00:00

  • Trophic effects of melanotropin-potentiating factor (MPF) on cultures of cells of the central nervous system.

    abstract::MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(97)00043-0

    authors: Owen DB,Morley JS,Ensor DM,Allen YS,Miles JB

    更新日期:1997-01-01 00:00:00

  • Metabolic effects of chronic obestatin infusion in rats.

    abstract::Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.03.023

    authors: Unniappan S,Speck M,Kieffer TJ

    更新日期:2008-08-01 00:00:00

  • Functional roles of the NTS2 and NTS3 receptors.

    abstract::Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2006.04.026

    authors: Mazella J,Vincent JP

    更新日期:2006-10-01 00:00:00

  • Protective effect of ghrelin on acetaminophen-induced liver injury in rat.

    abstract::Ghrelin is a peptide that has protective effects on many tissues of the body. It has anti-inflammatory and anti-oxidant effects. Acetaminophen, a commonly used analgesic-antipyretic drug, has hepatotoxic side effects. The aim of this study was to evaluate the protective role of ghrelin in liver toxicity due to acetami...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2010.08.009

    authors: Golestan Jahromi M,Nabavizadeh F,Vahedian J,Nahrevanian H,Dehpour AR,Zare-Mehrjardi A

    更新日期:2010-11-01 00:00:00

  • Thirst impairment elicited by intraventricular administration of vasopressin antagonists.

    abstract::To determine whether centrally released vasopressin influences thirst, observations of osmotic thirst threshold, osmotic load excretion and postloading restitution of plasma osmolality were made in dogs in control experiments and during infusion of AVP antagonists into the third ventricle. Significant elevation of osm...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(87)90128-8

    authors: Szczepanska-Sadowska E,Sobocinska J,Kozłowski S

    更新日期:1987-11-01 00:00:00

  • Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy.

    abstract::It is known that painful tissue injury evokes an increase in dynorphin in spinal neurons. It is not known, however, whether dynorphinergic systems respond similarly to the pain that accompanies peripheral neuropathy. Radioimmunoassays and immunocytochemistry were used to evaluate changes in dynorphin A(1-8) in the spi...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(90)90187-a

    authors: Kajander KC,Sahara Y,Iadarola MJ,Bennett GJ

    更新日期:1990-07-01 00:00:00

  • Entry of a cationic lytic-type peptide into the cytoplasm via endocytosis-dependent and -independent pathways in human glioma U251 cells.

    abstract::Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.09.015

    authors: Ohara K,Kohno M,Hamada T,Kawakami K

    更新日期:2013-12-01 00:00:00

  • Blockade of early and late retinal biochemical alterations associated with diabetes development by the selective bradykinin B1 receptor antagonist R-954.

    abstract::The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.02.008

    authors: Catanzaro O,Labal E,Andornino A,Capponi JA,Di Martino I,Sirois P

    更新日期:2012-04-01 00:00:00

  • Arginine-vasopressin stimulates CRH and ACTH release by rat adrenal medulla, acting via the V1 receptor subtype and a protein kinase C-dependent pathway.

    abstract::Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(96)00294-x

    authors: Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GG

    更新日期:1997-01-01 00:00:00