Abstract：
:Cone snails comprise approximately 700 species of venomous molluscs which have evolved the ability to generate multiple toxins with varied and exquisite selectivity. alpha-Conotoxin is a powerful tool for defining the composition and function of nicotinic acetylcholine receptors which play a crucial role in excitatory neurotransmission and are important targets for drugs and insecticides. An alpha4/7 conotoxin, Lp1.1, originally identified by cDNA and genomic DNA cloning from Conus leopardus, was found devoid of the highly conserved Pro residue in the first intercysteine loop. To further study this toxin, alpha-Lp1.1 was chemically synthesized and refolded into its globular disulfide isomer. The synthetic Lp1.1 induced seizure and paralysis on freshwater goldfish and selectively reversibly inhibited ACh-evoked currents in Xenopus oocytes expressing rat alpha3beta2 and alpha6alpha3beta2 nAChRs. Comparing the distinct primary structure with other functionally related alpha-conotoxins could indicate structural features in Lp1.1 that may be associated with its unique receptor recognition profile.
journal_name
Peptidesjournal_title
Peptidesauthors
Peng C,Han Y,Sanders T,Chew G,Liu J,Hawrot E,Chi C,Wang Cdoi
10.1016/j.peptides.2008.05.028subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1700-7issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(08)00250-7journal_volume
29pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.12.017
更新日期：2004-02-01 00:00:00
abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.01.007
更新日期：2018-03-01 00:00:00
abstract：:Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 micrograms/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagonizes dermorp...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90165-1
更新日期：1983-01-01 00:00:00
abstract：:The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.05.029
更新日期：2011-08-01 00:00:00
abstract：:The double-stranded RNA dependent protein kinase (PKR) is a negative regulator of cell proliferation and thus itself a target for modulation. We show that a cell-permeable peptide (PRI), containing a conserved double-stranded RNA binding motif found in PKR, inhibits activation of the kinase and activity to phosphoryla...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00297-7
更新日期：2000-10-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.10.022
更新日期：2008-01-01 00:00:00
abstract：:Urinary tract infections (UTI) are important health problems and predisposing causes of UTI are not entirely known. Neuro-immune interactions play an important role in human health and disease. Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as su...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.04.003
更新日期：2014-06-01 00:00:00
abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.027
更新日期：2009-05-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) immunoreactive material has been found in extracts of the intestine, however, the structure of intestinal CGRP is not known. Analytical reverse phase HPLC and ion-exchange FPLC revealed one predominant immunoreactive CGRP peak in rabbit intestinal extracts. This material was puri...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90014-g
更新日期：1991-03-01 00:00:00
abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.06.020
更新日期：2004-09-01 00:00:00
abstract：:To identify male-specific genes that could be involved in male development, we screened a subtracted male reproductive tract library and isolated a novel gene named Mar-Mrr (M. rosenbergii male reproduction-related gene). The Mar-Mrr cDNA sequence consists of 683 nucleotides with a 333 nucleotide open reading frame, e...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.09.004
更新日期：2006-04-01 00:00:00
abstract：:Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.01.018
更新日期：2014-03-01 00:00:00
abstract：:Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 microgram/kg IP and 0.5-5.0 microgram/IVT, indicating a peripheral mechanism in ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90066-8
更新日期：1981-01-01 00:00:00
abstract：:The melanocortin 4 receptor (MC4R) plays an essential role in weight regulation. Recently we could show that the MC4R is able to form receptor dimers. In the present study we investigated the role of extracellular cysteine residues and the structure of the third extracellular loop for receptor dimerization. None of th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.02.027
更新日期：2006-02-01 00:00:00
abstract：:We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00025-4
更新日期：1998-01-01 00:00:00
abstract：:Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.08.015
更新日期：2008-12-01 00:00:00
abstract：:We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.06.034
更新日期：2006-05-01 00:00:00
abstract：:The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90095-7
更新日期：1991-05-01 00:00:00
abstract：:We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02047-0
更新日期：1995-01-01 00:00:00
abstract：:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90060-8
更新日期：1983-07-01 00:00:00
abstract：:Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00190-3
更新日期：1997-01-01 00:00:00
abstract：:The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90030-2
更新日期：1989-03-01 00:00:00
abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90117-7
更新日期：1984-09-01 00:00:00
abstract：:This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00185-2
更新日期：2003-07-01 00:00:00
abstract：:beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.009
更新日期：2006-12-01 00:00:00
abstract：:A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00355-2
更新日期：2001-03-01 00:00:00
abstract：:Urotensin II (UII), first identified from goby urophysis, is a potent vasoactive peptide hormone and an endogenous ligand for an orphan G protein-coupled receptor GPR14, now named urotensin II receptor (UT-R). In addition to its vascular actions, UII has been shown to have mitogenic effects on tumor growth and some re...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.06.025
更新日期：2008-05-01 00:00:00
abstract：:The role of hippocampal dynorphin A (1-8) (Dyn A (1-8)) and kappa opioid receptors was investigated in the isolation-induced hypertensive rat (IHR). Male Sprague Dawley rats were either isolated (1 per cage) or grouped (3 per cage) for 7 days. Isolated rats exhibited increased blood pressure (systolic blood pressure 1...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00331-4
更新日期：2000-12-01 00:00:00
abstract：:Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. With the aim to further explore position 6 in the sequence of SHU-9119 and MT-II, we have designed, syn...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.02.012
更新日期：2007-06-01 00:00:00
