Abstract：
:This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin were identified from the MSP-8 protein. Those amino acids directly involved in interaction with erythrocytes were also determined for each one of the HABPs. Some of them specifically recognized 28, 46, and 73 kDa erythrocyte membrane proteins. Some HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by up to 98%, suggesting the MSP-8 protein's possible role in the invasion process.
journal_name
Peptidesjournal_title
Peptidesauthors
Puentes A,García J,Ocampo M,Rodríguez L,Vera R,Curtidor H,López R,Suarez J,Valbuena J,Vanegas M,Guzman F,Tovar D,Patarroyo MEdoi
10.1016/s0196-9781(03)00185-2subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1015-23issue
7eissn
0196-9781issn
1873-5169pii
S0196978103001852journal_volume
24pub_type
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