Abstract:
:Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2h/day. However, when rats undergo chronic (24h/day) ethanol drinking (or exposure to ethanol by vapor inhalation) and have periods of imposed ethanol abstinence, the reductions in ethanol drinking following NPY administration are enhanced in alcohol-preferring rats and are also observed in unselected Wistar rats. Thus, sensitivity to the effects of NPY on ethanol drinking appears to be altered by selective breeding for ethanol preference and by a prior history of chronic but intermittent exposure to ethanol.
journal_name
Peptidesjournal_title
Peptidesauthors
Badia-Elder NE,Gilpin NW,Stewart RBdoi
10.1016/j.peptides.2006.07.028subject
Has Abstractpub_date
2007-02-01 00:00:00pages
339-44issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00546-8journal_volume
28pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract::Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.01.015
更新日期:2016-04-01 00:00:00
abstract::Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170366
更新日期:2020-10-01 00:00:00
abstract::The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02121-3
更新日期:1996-01-01 00:00:00
abstract::The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90173-2
更新日期:1994-01-01 00:00:00
abstract::We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::An antiserum directed against the COOH-terminal region of neuropeptide K-(1-24)-peptide that shows only 0.5% reactivity with neuropeptide K has been used in radioimmunoassay to study the posttranslation processing of human beta-preprotachykinin. A primary midgut carcinoid tumor contained high concentration of substanc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90134-9
更新日期:1988-07-01 00:00:00
abstract::A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90145-2
更新日期:1986-11-01 00:00:00
abstract::The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.007
更新日期:2013-05-01 00:00:00
abstract::One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.04.016
更新日期:2012-07-01 00:00:00
abstract::High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00185-4
更新日期:1996-01-01 00:00:00
abstract::The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90126-0
更新日期:1994-01-01 00:00:00
abstract::Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90170-7
更新日期:1987-01-01 00:00:00
abstract::STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned S...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.015
更新日期:2005-01-01 00:00:00
abstract::The experiments reported here investigate the conditionability, using taste aversion conditioning, of the antagonistic effects of alpha-MSH on the thermoregulatory changes associated with injection of bacterial endotoxin lipopolysaccharide (LPS) in rats. Animals were administered LPS and then given alpha-MSH, as an un...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90182-1
更新日期:1994-01-01 00:00:00
abstract::The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.029
更新日期:2011-08-01 00:00:00
abstract::Cellular uptake of [125I] labelled DSIP at the luminal interface of the blood-brain barrier (BBB) was studied in the ipsilateral perfused in situ guinea pig forebrain. Regional unidirectional transfer constants (Kin) calculated from the multiple-time brain uptake analysis were 0.93, 1.33 and 1.66 microliter.min-1 g-1 ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90026-0
更新日期:1989-03-01 00:00:00
abstract::Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.023
更新日期:2011-02-01 00:00:00
abstract::Morphologic and immunohistochemical studies were conducted to ascertain whether pumiliotoxin-B (PTX-B), an indolizine alkaloid from the skin of the Neotropical dendrobatid frog, Dendrobates pumilio, affects the anatomic and immunohistochemical features of the electrically stimulated mouse vas deferens preparations. PT...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00066-2
更新日期:1999-01-01 00:00:00
abstract::Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.032
更新日期:2013-03-01 00:00:00
abstract::Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90063-b
更新日期:1990-05-01 00:00:00
abstract::Prolactin (PRL) is known to exert neuroprotective effects against excitotoxic damage in the hippocampus of female rats, both in vitro and in vivo. It is still unknown whether this effect can be seen in the male hippocampus and intracellular signaling mediating such action. To assess this, adult male CD-1 mice were sub...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170425
更新日期:2021-01-01 00:00:00
abstract::Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90047-s
更新日期:1991-09-01 00:00:00
abstract::An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170328
更新日期:2020-08-01 00:00:00
abstract::Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interacti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.10.018
更新日期:2015-01-01 00:00:00
abstract::We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00141-7
更新日期:1999-01-01 00:00:00
abstract::The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.007
更新日期:2006-04-01 00:00:00
abstract::Cardiac hypertrophy, an adaptive process to an increased hemodynamic overload, includes not only an increase in cell size but also qualitative changes in constituent proteins. Although swelling-activated chloride channels (I(Cl,swell)) chronically activate in hypertrophied atrial myocytes, the role of I(Cl,swell) in r...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.05.010
更新日期:2008-09-01 00:00:00
abstract::A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170353
更新日期:2020-09-01 00:00:00
abstract::Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.07.010
更新日期:2017-09-01 00:00:00
abstract::Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.03.012
更新日期:2015-06-01 00:00:00