Abstract:
:Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the C-terminal tryptic peptide of the CCK precursor. Similar material has previously been found in rat brain. In immunohistochemistry, a population of cells in rat small intestine is revealed, these also contain C-terminal gastrin/CCK activity, but for the most part do not react with gastrin-specific antibodies. During postnatal development their numbers increase considerably. We conclude that the C-terminal flanking peptide of proCCK is a useful marker for sites of CCK production.
journal_name
Peptidesjournal_title
Peptidesauthors
Jonsson AC,Varro A,Dockray GJdoi
10.1016/0196-9781(87)90170-7subject
Has Abstractpub_date
1987-01-01 00:00:00pages
95-101issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(87)90170-7journal_volume
8pub_type
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