Abstract:
:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement of circulating vasopressin is difficult to achieve, if at all. In search of a more robust way for quantifying vasopressin release, we identified copeptin, a glycopeptide with unknown function, as an alternative diagnostic target. Since copeptin is derived from the same precursor peptide as vasopressin, released amounts of copeptin should mirror those of vasopressin. With a newly developed sensitive sandwich immunoassay, we detected strongly elevated concentrations of fully processed copeptin in serum of septic shock patients. The magnitude of elevation and the high stability of copeptin in serum and plasma indicate that copeptin measurement is not affected by the problems, which are associated with the direct measurement of vasopressin, and thus is apparently suitable to indirectly determine the release of vasopressin.
journal_name
Peptidesjournal_title
Peptidesauthors
Struck J,Morgenthaler NG,Bergmann Adoi
10.1016/j.peptides.2005.04.019subject
Has Abstractpub_date
2005-12-01 00:00:00pages
2500-4issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00192-0journal_volume
26pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90152-u
更新日期:1990-11-01 00:00:00
abstract::Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2018.03.018
更新日期:2018-06-01 00:00:00
abstract::Dissociated muscle cells prepared from hearts of the pulmonate snail Helix aspersa were used to study signal transduction induced by molluscan cardioactive peptides. The effects of SCPb on the cAMP levels of whole hearts and the cell preparation were compared. The cells responded to SCPb with a dose-dependent increase...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00196-4
更新日期:1997-01-01 00:00:00
abstract::The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00208-9
更新日期:2000-02-01 00:00:00
abstract::The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00037-5
更新日期:1997-01-01 00:00:00
abstract::Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(99)00093-5
更新日期:1999-01-01 00:00:00
abstract::The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00251-6
更新日期:2002-12-01 00:00:00
abstract::The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90052-3
更新日期:1982-03-01 00:00:00
abstract::Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.07.012
更新日期:2010-11-01 00:00:00
abstract::Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.11.005
更新日期:2010-04-01 00:00:00
abstract::The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90109-9
更新日期:1986-09-01 00:00:00
abstract::Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00335-x
更新日期:1997-01-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::The interaction of two cathelicidin antimicrobial peptides, LL-37 and SMAP-29, with three bacterial polysaccharides, respectively, produced by Pseudomonas aeruginosa, Burkholderia cepacia and Klebsiella pneumoniae, was investigated to identify possible mechanisms adopted by lung pathogens to escape the action of innat...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.01.020
更新日期:2005-07-01 00:00:00
abstract::There is a well-documented association between cyclic changes to food intake and the changing ovarian hormone levels of the reproductive cycle in female mammals. Limited research on appetite-controlling gastrointestinal peptides has taken place in females, simply because regular reproductive changes in steroid hormone...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.02.010
更新日期:2017-04-01 00:00:00
abstract::The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90133-x
更新日期:1983-05-01 00:00:00
abstract::HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90152-s
更新日期:1992-01-01 00:00:00
abstract::Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.08.004
更新日期:2017-10-01 00:00:00
abstract::Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90166-4
更新日期:1985-07-01 00:00:00
abstract::Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00206-l
更新日期:1995-01-01 00:00:00
abstract::The discovery of several adipokines with diverse activities and their involvement in regulation of various pathophysiological functions of human body has challenged the researchers. In the family of adipokine, chemerin is a novel and unique addition. Ever since the first report on chemerin as a chemo-attractant protei...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2014.09.019
更新日期:2014-12-01 00:00:00
abstract::The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90145-9
更新日期:1989-05-01 00:00:00
abstract::Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90116-0
更新日期:1985-05-01 00:00:00
abstract::The effect of proadrenomedullin N-terminal 20 peptide (PAMP) on the proliferative activity of rat zona glomerulosa (ZG) cells has been investigated. Dispersed rat ZG cells were cultured in vitro for 24 h and then exposed to PAMP for an additional 24 h, and the proliferation rate was assessed by the 5-bromo-2'-deoxyuri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00518-6
更新日期:2001-11-01 00:00:00
abstract::In this study we examined the effects of 2% saline loading (S), partial restriction of water consumption (R) or a combination of S or R with dexamethasone (DEX) treatment for 14 days on corticotropin releasing factor (CRF)-41 content of the neurointermediate lobe (NIL) and supraoptic nuclei (SON) of male Wistar rats. ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90109-i
更新日期:1990-01-01 00:00:00
abstract::Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.016
更新日期:2004-01-01 00:00:00
abstract::We have evaluated a new immunoradiometric assay (IRMA) for calcitonin (CT) (Medgenix, Belgium). The detection limit of immunoreactive CT (IR-CT) was 2.8 pg/ml, and plasma levels of IR-CT of 134 healthy adults (dynamic range, 2.8-1000 pg/ml) were < 19 pg/ml (median 4.1 pg/ml). Both basal and pentagastrin-stimulated IR-...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00177-4
更新日期:1995-01-01 00:00:00
abstract::A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90247-x
更新日期:1984-03-01 00:00:00
abstract::This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00185-2
更新日期:2003-07-01 00:00:00
abstract::We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00025-4
更新日期:1998-01-01 00:00:00