Abstract:
:A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of the resting membrane potential was -46.5 +/- 1.8 mV (S.E.) (n = 13), while the mean resting input resistance was 21.2 +/- 4.3 M omega (S.E.) (N = 13). Dibutyryl cyclic AMP (2 X 10(-3)M) caused a marked hyperpolarization of about 30 mV accompanied by a reduction of input resistance. The transplantable tumor and its cultured cell line developed in this study have demonstrated their effectiveness as a reliable experimental model for use in pancreatic cancer research.
journal_name
Peptidesjournal_title
Peptidesauthors
Ueda N,Suzuki Y,Utsumi M,Obara T,Okamura K,Namiki Mdoi
10.1016/0196-9781(84)90247-xsubject
Has Abstractpub_date
1984-03-01 00:00:00pages
423-8issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(84)90247-Xjournal_volume
5pub_type
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