Abstract:
:During a stress response, various neuropeptides are secreted in a spatiotemporally coordinated way in the brain. For a precise understanding of peptide functions in a stress response, it is important to investigate when and where they are released, how they diffuse, and how they are broken down in the brain. In the past two decades, genetically encoded fluorescent calcium indicators have greatly advanced our knowledge of the functions of specific neuronal activity in regulation of behavioral changes and physiological responses during stress. In addition, various kinds of structural information on G-protein-coupled receptors (GPCRs) for neuropeptides have been revealed. Recently, genetically encoded fluorescent sensors have been developed for detection of neurotransmitters by making use of conformational changes induced by ligand binding. In this review, we summarize the recent and upcoming advances of techniques for detection of neuropeptides and then present several open questions that will be solved by application of recent or upcoming technical advances in detection of neuropeptides in vivo.
journal_name
Peptidesjournal_title
Peptidesauthors
Inutsuka A,Ino D,Onaka Tdoi
10.1016/j.peptides.2020.170456subject
Has Abstractpub_date
2020-11-24 00:00:00pages
170456eissn
0196-9781issn
1873-5169pii
S0196-9781(20)30205-9journal_volume
136pub_type
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