Abstract:
:Vasoactive intestinal peptide (VIP) is a neuropeptide present in high concentrations in the hippocampus. The studies reported here demonstrate that VIP administered into the third ventricle of the brain caused amnesia in mice trained on a left-right footshock avoidance task in a T-maze. VIP resulted in amnesia when administered directly into the rostral portion of the hippocampus at a 10-fold lower dose than was needed to produce amnesia when VIP was administered intracerebroventricularly. When VIP was administered 24 hr after training, it failed to impair retention measured a week later. VIP receptor antagonist ([4-Cl-D-Phe6,Leu17]VIP) enhanced retention when administered into the rostral portion of the hippocampus, suggesting that VIP plays a physiological role in memory modulation. VIP receptor antagonist administered 24 hr after training did not facilitate retention. To gain some insight as to how VIP may be affecting memory processing, we determined if some memory-improving compounds showed a selective ability to block amnesia induced by VIP. The amnestic effect of VIP was blocked by peripheral administration of the memory-enhancing agents, arecoline, naloxone and ST 587 (a noradrenergic receptor agonist) but not by cholecystokinin octapeptide. Central administration of arecoline, but not neuropeptide Y, blocked the amnestic effect of VIP. It is concluded that VIP is a potent amnestic peptide.
journal_name
Peptidesjournal_title
Peptidesauthors
Flood JF,Garland JS,Morley JEdoi
10.1016/0196-9781(90)90012-tsubject
Has Abstractpub_date
1990-09-01 00:00:00pages
933-8issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(90)90012-Tjournal_volume
11pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90138-7
更新日期:1993-05-01 00:00:00
abstract::Smooth muscle cells isolated by enzymatic digestion were used to determine the direct effects of galanin on circular and longitudinal muscle layers from dog proximal colon and to investigate the intracellular pathways involved in these effects. Effects of galanin were compared to those observed with other contracting ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90088-4
更新日期:1994-01-01 00:00:00
abstract::The peptide IIAEK derived from beta-lactoglobulin has a hypocholesterolemic activity greater than that of beta-sitosterol. To create food proteins with multiple copies of this valuable peptide sequence, we introduced tandem multimers of the nucleotide sequence encoding the peptide into DNA regions corresponding to the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.11.007
更新日期:2006-06-01 00:00:00
abstract::An antiserum directed against the COOH-terminal region of neuropeptide K-(1-24)-peptide that shows only 0.5% reactivity with neuropeptide K has been used in radioimmunoassay to study the posttranslation processing of human beta-preprotachykinin. A primary midgut carcinoid tumor contained high concentration of substanc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90134-9
更新日期:1988-07-01 00:00:00
abstract::Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00124-4
更新日期:2003-05-01 00:00:00
abstract::A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.001
更新日期:2012-02-01 00:00:00
abstract::ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90128-r
更新日期:1990-01-01 00:00:00
abstract::The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170443
更新日期:2020-11-07 00:00:00
abstract::Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90008-x
更新日期:1980-01-01 00:00:00
abstract::Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02123-x
更新日期:1996-01-01 00:00:00
abstract::Chicken-I and chicken-II gonadotropin-releasing hormone (cI-GnRH and cII-GnRH) were shown to be differentially distributed in the brain of a turtle, Trachemys scripta, by HPLC and specific radioimmunoassays. The cI-GnRH was most concentrated in the median eminence (ME), while cII-GnRH was most concentrated in the caud...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90033-d
更新日期:1993-03-01 00:00:00
abstract::Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00044-5
更新日期:2003-02-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00
abstract::The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90117-7
更新日期:1984-09-01 00:00:00
abstract::Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90113-7
更新日期:1989-07-01 00:00:00
abstract::The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90149-b
更新日期:1993-05-01 00:00:00
abstract::A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90247-x
更新日期:1984-03-01 00:00:00
abstract::On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.02.017
更新日期:2004-04-01 00:00:00
abstract::Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00194-1
更新日期:2000-02-01 00:00:00
abstract::Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin releas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90012-8
更新日期:1983-09-01 00:00:00
abstract::Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.03.005
更新日期:2004-06-01 00:00:00
abstract::The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00068-0
更新日期:1998-01-01 00:00:00
abstract::Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90073-c
更新日期:1992-05-01 00:00:00
abstract::There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.09.005
更新日期:2011-10-01 00:00:00
abstract::The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90134-6
更新日期:1982-01-01 00:00:00
abstract::The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90095-7
更新日期:1991-05-01 00:00:00
abstract::Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.025
更新日期:2006-03-01 00:00:00
abstract::Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00057-1
更新日期:1999-01-01 00:00:00
abstract::The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of insect species. A previous solution conformation study of an active, restricted-conformation cyclic analog, identified two possible turn conformations as the likel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00651-9
更新日期:2002-04-01 00:00:00
abstract::Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00271-1
更新日期:2003-01-01 00:00:00