Abstract:
:Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg) significantly inhibited HPD (2 mg/kg)-induced increase in dopamine (DA) release from the rat striatum. This effect of CLT was also antagonized by proglumide. These results suggest that CLT (160 micrograms/kg) primarily acts on cholecystokinin-A receptor in the brain, exerts some modulatory influence on HPD binding to striatal DA receptors via unknown neural pathways and, consequently, inhibits HPD catalepsy.
journal_name
Peptidesjournal_title
Peptidesauthors
Ibii N,Ikeda M,Takahara Y,Eigyo M,Akiyoshi T,Matsushita Adoi
10.1016/0196-9781(89)90113-7subject
Has Abstractpub_date
1989-07-01 00:00:00pages
779-83issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(89)90113-7journal_volume
10pub_type
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