Cloning and characterization of the guinea pig neuropeptide Y receptor Y5.

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin...

journal_title：Peptides

authors： Puentes A,García J,Ocampo M,Rodríguez L,Vera R,Curtidor H,López R,Suarez J,Valbuena J,Vanegas M,Guzman F,Tovar D,Patarroyo ME

更新日期：2003-07-01 00:00:00

abstract：:As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...

journal_title：Peptides

authors： Wang K,Yan J,Dang W,Liu X,Chen R,Zhang J,Zhang B,Zhang W,Kai M,Yan W,Yang Z,Xie J,Wang R

更新日期：2013-01-01 00:00:00

abstract：:Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppres...

journal_title：Peptides

authors： Itoh S,Katsuura G

更新日期：1985-03-01 00:00:00

abstract：:Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ETA receptor (R) and ETBR on cancer cells. High levels of tumor ET-1 and ETAR are associated with poor survival of lung cancer patients. Here the e...

journal_title：Peptides

authors： Moody TW,Ramos-Alvarez I,Moreno P,Mantey SA,Ridnour L,Wink D,Jensen RT

更新日期：2017-04-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...

journal_title：Peptides

authors： Yang J,Shi QD,Song TB,Feng GF,Zang WJ,Zong CH,Chang L

更新日期：2013-04-01 00:00:00

abstract：:We performed the first comprehensive peptidomic analysis of neurohormones from hemipteran insects by analyzing the neuropeptides of two major neurohemal organs, namely the corpora cardiaca and abdominal perisympathetic organs. For the experiments we selected four related species of polyphagous stinkbugs (Pentatomidae)...

journal_title：Peptides

authors： Predel R,Russell WK,Russell DH,Lopez J,Esquivel J,Nachman RJ

更新日期：2008-02-01 00:00:00

abstract：:Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...

journal_title：Peptides

authors： Tsutsui C,Kajihara K,Yanaka T,Sakata I,Itoh Z,Oda S,Sakai T

更新日期：2009-02-01 00:00:00

abstract：:Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...

journal_title：Peptides

authors： Heyliger SO,Payza K,Rothman RB

更新日期：1998-01-01 00:00:00

abstract：:Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. With the aim to further explore position 6 in the sequence of SHU-9119 and MT-II, we have designed, syn...

journal_title：Peptides

authors： Grieco P,Cai M,Han G,Trivedi D,Campiglia P,Novellino E,Hruby VJ

更新日期：2007-06-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, originally isolated from human pheochromocytomas, and then found to be widely distributed in the various body systems. ADM derives from preproadrenomedullin, a 185-amino acid residue prohormone, containing at its N-terminal a 20-amino acid sequence, named proadrenomedulli...

journal_title：Peptides

authors： Nussdorfer GG,Rossi GP,Mazzocchi G

更新日期：1997-01-01 00:00:00

abstract：:Nonmammalian peptides of the tachykinin, bombesin and opioid families, injected into the brain ventricles, potently and specifically affect drinking behaviour of rats and pigeons. These peptides, or at least their counterparts, have been found in the brain of mammals and birds. It has been hypothesized that these endo...

journal_title：Peptides

authors： de Caro G,Massi M

更新日期：1985-01-01 00:00:00

abstract：:Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...

journal_title：Peptides

authors： Zhang X,Lu XM,Huang LF,Li X

更新日期：2013-05-01 00:00:00

abstract：:To determine if insulin-like growth factor (IGF)-1 and -2, FSH, or leptin alter IGF-binding protein (IGFBP)-2, -3, -4, and -5 mRNA levels in bovine granulosa and (or) theca cells, granulosa and theca cells were collected from bovine ovarian follicles, plated for 48 h in 10% FCS and then treated for 24 h in serum-free ...

journal_title：Peptides

authors： Voge JL,Aad PY,Santiago CA,Goad DW,Malayer JR,Allen D,Spicer LJ

更新日期：2004-12-01 00:00:00

abstract：:Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay us...

journal_title：Peptides

authors： Yu KL,Sherwood NM,Peter RE

更新日期：1988-05-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...

journal_title：Peptides

authors： Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

更新日期：2004-04-01 00:00:00

abstract：:In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. PC-12 cell...

journal_title：Peptides

authors： Rajput SK,Siddiqui MA,Kumar V,Meena CL,Pant AB,Jain R,Sharma SS

更新日期：2011-06-01 00:00:00

abstract：:Recent pharmacological data strongly support the hypothesis of delta receptor subtypes as mediators of both supraspinal and spinal antinociception (delta 1 and delta 2 receptors). In vitro ligand binding data, which are fully supportive of the in vivo data, are still lacking. A previous study indicated that [3H][D-Ala...

journal_title：Peptides

authors： Xu H,Partilla JS,de Costa BR,Rice KC,Rothman RB

更新日期：1992-11-01 00:00:00

abstract：:Mustard oil, which stimulates small diameter afferents, was used to evoke the expression of the oncogene c-fos in the lumbar spinal cord. C-fos-like immunoreactivity was concentrated in, but not limited to, neuronal nuclei of laminae I and II of the lumbar dorsal horn. Double-label immunocytochemistry was used to dete...

journal_title：Peptides

authors： Pretel S,Piekut DT

更新日期：1991-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) injected into the hypothalamus stimulates feeding and affects pituitary secretion. Insulin-deficient diabetes and food deprivation markedly increase hypothalamic NPY and NPY mRNA levels, suggesting increased activity of NPYergic pathways in the hypothalamus, which could account for hyperphagia and...

journal_title：Peptides

authors： Frankish HM,McCarthy HD,Dryden S,Kilpatrick A,Williams G

更新日期：1993-09-01 00:00:00

abstract：:The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...

journal_title：Peptides

authors： Sharif NA,Hughes J

更新日期：1989-05-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary aim of this study was to identify the TIMP-2 region involved in binding to the previously identified receptor integrin α3β1, and to determine whe...

journal_title：Peptides

authors： Seo DW,Saxinger WC,Guedez L,Cantelmo AR,Albini A,Stetler-Stevenson WG

更新日期：2011-09-01 00:00:00

abstract：:[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...

journal_title：Peptides

authors： D'Souza MM,Carr JA

更新日期：1998-01-01 00:00:00

abstract：:Insect flight requires rapid mobilization of energy reserves during flight, which is mediated and regulated by hormonal control via adipokinetic hormones. The structure of the G-protein receptors to which these hormones bind, are crucial in understanding many of the physiological processes in which they play a central...

journal_title：Peptides

authors： Mugumbate G,Jackson GE,van der Spoel D

更新日期：2011-03-01 00:00:00

abstract：:The gut tissues and associated nervous system of the African migratory locust, Locusta migratoria, were found to contain FMRFamide-like immunoreactive (FLI) material throughout the five larval instars and 2 weeks into the adult stage in both males and females. FMRFamide-like immunoreactivity associated with the locust...

journal_title：Peptides

authors： Hill SR,Orchard I

更新日期：2003-10-01 00:00:00

abstract：:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...

journal_title：Peptides

authors： Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Q

更新日期：2012-05-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...

journal_title：Peptides

authors： Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GG

更新日期：1997-01-01 00:00:00