Characterization of [125I]beta-endorphin binding sites in the rat caudal dorsomedial medulla.

abstract：:Numerous works associate the MCH peptide, and the hypothalamic neurons that produce it, to the feeding behavior and energy homeostasis. It is commonly admitted that MCH is an orexigenic peptide, and MCH neurons could be under the control of arcuate NPY and POMC neurons. However, the literature data is not always conco...

journal_title：Peptides

authors： Griffond B,Risold PY

更新日期：2009-11-01 00:00:00

abstract：:Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...

journal_title：Peptides

authors： Unniappan S,Speck M,Kieffer TJ

更新日期：2008-08-01 00:00:00

abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...

journal_title：Peptides

authors： Sanders HM,Lust R,Teller JK

更新日期：2009-05-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:Carcinogenesis is a multistage process derived from a combination of multiple heritable and environmental factors. It has been reported that populations consuming high levels of soybean products have both lower cancer incidence and mortality rates in the western countries. Lunasin is a novel and promising peptide init...

journal_title：Peptides

authors： Hernández-Ledesma B,Hsieh CC,de Lumen BO

更新日期：2009-02-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...

journal_title：Peptides

authors： Csabafi K,Jászberényi M,Bagosi Z,Tóth G,Wollemann M,Telegdy G

更新日期：2011-08-01 00:00:00

abstract：:A 20-kDa protein with substantial N-terminal sequence homology to thaumatin-like proteins was isolated from ripe fruits of the emperor banana, Musa basjoo cv. 'emperor banana'. The isolation procedure entailed (NH(4))(2)SO(4) precipitation, ion exchange chromatography on DEAE-cellulose, and affinity chromatography on ...

journal_title：Peptides

authors： Ho VS,Wong JH,Ng TB

更新日期：2007-04-01 00:00:00

abstract：:Malaria lactate dehydrogenase, a glycolytic enzyme, is a malaria diagnostic target in lateral flow immunochromatographic rapid diagnostic tests. Recombinant Plasmodium yoelii LDH was cloned into the pET-28a vector, expressed and the expressed protein purified from a Ni-NTA affinity matrix. A pan-malarial LDH antibody ...

journal_title：Peptides

authors： Hurdayal R,Achilonu I,Choveaux D,Coetzer TH,Dean Goldring JP

更新日期：2010-04-01 00:00:00

abstract：:Female Sprague-Dawley rat pups were injected SC with either ACTH(1-24) (0.5 mg/kg) or saline vehicle once daily from postnatal day 1 (day of birth) to day 7. Plasma corticosterone (CORT) levels were recorded via radioimmunoassay (RIA) on day 4 to measure adrenal response to these treatments. Hypothalamic 5-HT and DA f...

journal_title：Peptides

authors： Alves SE,Akbari HM,Azmitia EC,Strand FL

更新日期：1993-03-01 00:00:00

abstract：:Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...

journal_title：Peptides

authors： Ohara K,Kohno M,Hamada T,Kawakami K

更新日期：2013-12-01 00:00:00

abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...

journal_title：Peptides

authors： Ivars J,Butruille L,Knauf C,Bouckenooghe T,Mayeur S,Vieau D,Valet P,Deruelle P,Lesage J

更新日期：2012-05-01 00:00:00

abstract：:The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...

journal_title：Peptides

authors： Catanzaro O,Labal E,Andornino A,Capponi JA,Di Martino I,Sirois P

更新日期：2012-04-01 00:00:00

abstract：:To confirm and extend the results of previous studies which demonstrated central cardiovascular effects of vasopressin in anesthetized rats, we determined blood pressure and heart rate changes for 30 minutes after intracerebroventricular injections of arginine vasopressin, arginine vasotocin and oxytocin in conscious ...

journal_title：Peptides

authors： Zerbe RL,Kirtland S,Faden AI,Feuerstein G

更新日期：1983-09-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...

journal_title：Peptides

authors： Del Ry S,Cabiati M,Lionetti V,Emdin M,Recchia FA,Giannessi D

更新日期：2008-12-01 00:00:00

abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...

journal_title：Peptides

authors： Kurkowski R,Kummer W,Heym C

更新日期：1990-01-01 00:00:00

abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...

journal_title：Peptides

authors： Howl J,Howl L,Jones S

更新日期：2018-03-01 00:00:00

abstract：:Incorporation of N-succinimidyl-3(4-hydroxyphenyl) propionate (Bolton-Hunter reagent) or its 125I-labeled derivative into peptides can be selectively directed towards either alpha- or epsilon-amine functions by modifying the pH of the reaction. Acylation of alpha-amino groups is favored at pH 6.5 whereas epsilon-amino...

journal_title：Peptides

authors： Gaudriault G,Vincent JP

更新日期：1992-11-01 00:00:00

abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...

journal_title：Peptides

authors： Gao Z,Wang S,Qi G,Pan H,Zhang L,Zhou X,Liu J,Zhao X,Wu J

更新日期：2012-11-01 00:00:00

abstract：:We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...

journal_title：Peptides

authors： Fukuhara S,Mukai H,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00

abstract：:In the present study, we present for the first time the presence and distribution of neuropeptide Y (NPY) receptors Y1 and Y2 in the human postmortem heart using specific antibodies raised against extracellular parts of the receptors. A more intensive staining against the Y2 than against the Y1 receptors was detected ...

journal_title：Peptides

authors： Jönsson-Rylander AC,Nordlander M,Svindland A,Ilebekk A

更新日期：2003-02-01 00:00:00

abstract：:New dual immunocytochemical staining procedures were used in the same tissue section to elucidate the distribution and co-existence of CRF and vasopressin in parvocellular neuronal perikarya in the paraventricular nucleus (PVN) of rat hypothalamus. CRF immunostained cells were for the most part concentrated in the med...

journal_title：Peptides

authors： Piekut DT,Joseph SA

更新日期：1986-09-01 00:00:00

abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...

journal_title：Peptides

authors： Li Y,Xiao J,Tian H,Pei Y,Lu Y,Han X,Liu Y,Zhong W,Sun B,Fang F,Shu H

更新日期：2013-11-01 00:00:00

abstract：:Both diapause hormone (DH) and ecdysone (E) are capable of terminating pupal diapause in members of the Helicoverpa/Heliothis complex. In this study we examine how the transcript encoding prothoracicotropic hormone (PTTH), the neuropeptide that stimulates the prothoracic gland to produce E, and the transcript encoding...

journal_title：Peptides

authors： Zhang Q,Denlinger DL

更新日期：2012-03-01 00:00:00

abstract：:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...

journal_title：Peptides

authors： Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins J

更新日期：2005-10-01 00:00:00

abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...

journal_title：Peptides

authors： Botz B,Imreh A,Sándor K,Elekes K,Szolcsányi J,Reglődi D,Quinn JP,Stewart J,Zimmer A,Hashimoto H,Helyes Z

更新日期：2013-05-01 00:00:00

abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...

journal_title：Peptides

authors： Hoover DB

更新日期：1991-09-01 00:00:00

abstract：:The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...

journal_title：Peptides

authors： Flanagan-Cato LM,Moga CN,Fluharty SJ

更新日期：1996-01-01 00:00:00