Role of adrenomedullin and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis.

abstract：:The somatostatin analogs D-Phe-Cys-D-Trp-Lys-Thr-Cys-Thr and the corresponding penicillamine compounds have been prepared and tested for their ability to displace [3H]naloxone and [3H] [D-Ala2, D-Leu5]enkephalin from rat brain receptors. While somatostatin and the cystine containing peptide displayed little or no pref...

journal_title：Peptides

authors： Pelton JT,Gulya K,Hruby VJ,Duckles S,Yamamura HI

更新日期：1985-01-01 00:00:00

abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

journal_title：Peptides

authors： Sato A,Yokoyama I,Ebina K

更新日期：2015-11-01 00:00:00

abstract：:We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...

journal_title：Peptides

authors： Brown AG,Leite RS,Engler AJ,Discher DE,Strauss JF 3rd

更新日期：2006-07-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...

journal_title：Peptides

authors： Altstein M

更新日期：2004-09-01 00:00:00

abstract：:Large species differences have been previously observed in the pharmacology of bradykinin (BK) B2 receptor antagonists. We investigated the effect of two novel non-peptide antagonists, compound 9 (a benzodiazepine peptidomimetic related to icatibant) and the thiosemicarbazide bradyzide on the rabbit B2 receptor (contr...

journal_title：Peptides

authors： Marceau F,Houle S,Bouthillier J,Said NB,Garratt PJ,Dziadulewicz EK

更新日期：2001-09-01 00:00:00

abstract：:Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...

journal_title：Peptides

authors： Apostol CR,Hay M,Polt R

更新日期：2020-09-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:This study presents the binding and functional properties of the mouse NPFF(2) (mNPFF(2)) receptor, in comparison with its human counterpart (hNPFF(2)). Binding experiments were performed by using the NPFF(2) selective radioligand [(3)H]-EYF in membranes from CHO cells transfected with mouse and human NPFF(2) receptor...

journal_title：Peptides

authors： Talmont F,Moulédous L,Piedra-Garcia L,Schmitt M,Bihel F,Bourguignon JJ,Zajac JM,Mollereau C

更新日期：2010-02-01 00:00:00

abstract：:Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...

journal_title：Peptides

authors： König E,Bininda-Emonds OR,Shaw C

更新日期：2015-01-01 00:00:00

abstract：:We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intr...

journal_title：Peptides

authors： Tamaoki J,Kanemura T,Kobayashi K,Sakai N,Takizawa T

更新日期：1989-09-01 00:00:00

abstract：:Expression of the two gonadotropin-releasing hormone homologue peptides GnRHI and GnRHII and their receptor GnRHR has been demonstrated in a number of malignancies. In hormone-dependent breast cancer, GnRH analogs are used for therapy in premenopausal women. Gene expression of GnRHI, II and R was studied in breast bio...

journal_title：Peptides

authors： Pazaitou-Panayiotou K,Chemonidou C,Poupi A,Koureta M,Kaprara A,Lambropoulou M,Constantinidis TC,Galaktidou G,Koffa M,Kiziridou A,Kakolyris S,Kolios G,Kortsaris A,Chatzaki E

更新日期：2013-04-01 00:00:00

abstract：:The present study examined 1) oxidative stress and gastric lesions induced by thyrotropin releasing hormone (TRH) 2) The effect of a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, ICS 205930 on protective effect of calcitonin on gastric lesions produced by TRH. Calcitonin (5 micrograms/10 microliter) was injected i...

journal_title：Peptides

authors： Erin N,Yegen BC,Oktay S

更新日期：1997-01-01 00:00:00

abstract：:Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...

journal_title：Peptides

authors： Fiedorowicz E,Jarmołowska B,Iwan M,Kostyra E,Obuchowicz R,Obuchowicz M

更新日期：2011-04-01 00:00:00

abstract：:Antimicrobial peptides allegedly exert their action on microbial membranes. Bovine lactoferrin enfold two antimicrobial domains, lactoferricin B (LFcin B) and lactoferrampin (LFampin). Effects of representative peptides thereof on the membranes of Candida albicans and Escherichia coli were investigated. Confocal laser...

journal_title：Peptides

authors： van der Kraan MI,van Marle J,Nazmi K,Groenink J,van 't Hof W,Veerman EC,Bolscher JG,Nieuw Amerongen AV

更新日期：2005-09-01 00:00:00

abstract：:Apelin, a newly identified bioactive adipokine, has been found to play important roles in multiple diseases, including diabetes, hypertension and cardiovascular diseases with unclear molecular mechanisms. The present study aimed to investigate the effects of apelin on endoplasmic reticulum (ER) stress in the pancreas ...

journal_title：Peptides

authors： Chen H,Zheng C,Zhang X,Li J,Li J,Zheng L,Huang K

更新日期：2011-08-01 00:00:00

abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...

journal_title：Peptides

authors： Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

更新日期：2017-07-01 00:00:00

abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...

journal_title：Peptides

authors： de Marco R,Lovato DV,Torquato RJ,Clara RO,Buarque DS,Tanaka AS

更新日期：2010-07-01 00:00:00

abstract：:The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...

journal_title：Peptides

authors： Devemy E,Blaschuk OW

更新日期：2008-11-01 00:00:00

abstract：:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by...

journal_title：Peptides

authors： Delgado M,Martínez C,Leceta J,Garrido E,Gomariz RP

更新日期：1996-01-01 00:00:00

abstract：:We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...

journal_title：Peptides

authors： Fujimoto M,Sakamoto T,Kanetoh T,Osaka M,Moriyama S

更新日期：2006-05-01 00:00:00

abstract：:A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...

journal_title：Peptides

authors： Gafvelin G,Andersson M,Dimaline R,Jörnvall H,Mutt V

更新日期：1988-05-01 00:00:00

abstract：:A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...

journal_title：Peptides

authors： Brown MR,Crim JW,Arata RC,Cai HN,Chun C,Shen P

更新日期：1999-01-01 00:00:00

abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...

journal_title：Peptides

authors： Varndell IM,Tapia FJ,Probert L,Buchan AM,Gu J,De Mey J,Bloom SR,Polak JM

更新日期：1982-05-01 00:00:00

abstract：:Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...

journal_title：Peptides

authors： Ibata Y,Kawakami F,Fukui K,Okamura H,Obata-Tsuto HL,Tsuto T,Terubayashi H

更新日期：1984-01-01 00:00:00

abstract：:Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...

journal_title：Peptides

authors： Shi JB,Guo ZF,Zheng X,Wang ZB,Ma YJ

更新日期：2012-12-01 00:00:00

abstract：:Prothymosin alpha (ProTα), a nuclear protein, plays multiple functions including cell survival. Most recently, we demonstrated that the active 30-amino acid peptide sequence/P30 (amino acids 49-78) in ProTα retains its substantial activity in neuroprotection in vitro and in vivo as well as in the inhibition of cerebra...

journal_title：Peptides

authors： Halder SK,Sugimoto J,Matsunaga H,Ueda H

更新日期：2013-05-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells transition to a mesenchymal phenotype, has been implicated in the pathogenesis of renal fibrosis. Apelin, a bioactive peptide, has recently been recognized to protect against renal profibrotic activity, but the underlyi...

journal_title：Peptides

authors： Wang LY,Diao ZL,Zheng JF,Wu YR,Zhang QD,Liu WH

更新日期：2017-10-01 00:00:00

abstract：:By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...

journal_title：Peptides

authors： Allard M,Rousselot P,Lombard MC,Theodosis DT

更新日期：1999-01-01 00:00:00

abstract：:Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the 133Xe method. Using this technique we measured...

journal_title：Peptides

authors： Jørgensen JC,Sejrsen P

更新日期：1990-05-01 00:00:00