The protective effect of 5-HT3 receptor antagonist in thyrotropin releasing hormone-induced gastric lesions.

abstract：:Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...

journal_title：Peptides

authors： Micevych PE,Elde RP

更新日期：1982-07-01 00:00:00

abstract：:The evolution, function and interaction of ligand-receptor pairs are of major pharmaceutical interest. Comparative sequence analysis approaches using data from phylogenetically distant organisms can provide insights into their origin and possible physiological roles. The present review focuses on the pituitary adenyla...

journal_title：Peptides

authors： Cardoso JC,Vieira FA,Gomes AS,Power DM

更新日期：2007-09-01 00:00:00

abstract：:Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...

journal_title：Peptides

authors： Okuno A,Hasegawa Y,Ohira T,Nagasawa H

更新日期：2001-02-01 00:00:00

abstract：:A new CCK8 related peptide, Boc[Nle28,Nle31]CCK27-33 (Boc[diNle]CCK7) was synthesized and tested for cholecystokinic activity, at both the peripheral and the central level. This analogue, protected against both chemical oxidation and enzymatic degradation by aminopeptidases, was shown to be equipotent to CCK8 in relea...

journal_title：Peptides

authors： Ruiz-Gayo M,Daugé V,Menant I,Bégué D,Gacel G,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:While neuropeptides of the allatostatin family inhibit in vitro production of juvenile hormone, which modulates aspects of development and reproduction in the cockroach, Diploptera punctata, they are susceptible to inactivation by peptidases in the hemolymph, gut, and bound to internal tissues. Patterns of peptidase c...

journal_title：Peptides

authors： Nachman RJ,Garside CS,Tobe SS

更新日期：1999-01-01 00:00:00

abstract：:Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...

journal_title：Peptides

authors： Zamora-Bustillos R,Rivera-Reyes R,Aguilar MB,Michel-Morfín E,Landa-Jaime V,Falcón A,Heimer EP

更新日期：2014-03-01 00:00:00

abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

journal_title：Peptides

authors： Sato A,Yokoyama I,Ebina K

更新日期：2015-11-01 00:00:00

abstract：:Three analogs of Mast Cell Degranulating (MCD) peptide with C-terminal and one analog with N- and C-terminal deletions were synthesized and assayed for histamine-releasing activity in mast cells. Des(20-22)-MCD and des(21)-MCD markedly decreased this activity. In des(16-17,21)-MCD this activity was completely abolishe...

journal_title：Peptides

authors： Buku A,Maulik G,Hook WA

更新日期：1998-01-01 00:00:00

abstract：:Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Dist...

journal_title：Peptides

authors： Siemion IZ,Gawlowska M,Krajewski K,Strug I,Wieczorek Z

更新日期：2003-08-01 00:00:00

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance re...

journal_title：Peptides

authors： Hadjiivanova C,Kehayov R,Petkov VV,Amblard M,Martinez J

更新日期：1995-01-01 00:00:00

abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...

journal_title：Peptides

authors： Fried S,O'Neill K,Hawes BE

更新日期：2002-08-01 00:00:00

abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

journal_title：Peptides

authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

更新日期：1986-07-01 00:00:00

abstract：:We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...

journal_title：Peptides

authors： Kanduc D,Lucchese A,Mittelman A

更新日期：2001-12-01 00:00:00

abstract：:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized ...

journal_title：Peptides

authors： Du YC,Wu JH,Jiang XM,Gu YJ

更新日期：1994-01-01 00:00:00

abstract：:Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...

journal_title：Peptides

authors： Vigh S,Schally AV

更新日期：1984-01-01 00:00:00

abstract：:The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...

journal_title：Peptides

authors： Bick RJ,Poindexter BJ,Davis RA,Schiess MC

更新日期：2005-11-01 00:00:00

abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...

journal_title：Peptides

authors： Pantic JM,Radosavljevic GD,Jovanovic IP,Arsenijevic NN,Conlon JM,Lukic ML

更新日期：2015-09-01 00:00:00

abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...

journal_title：Peptides

authors： Kato J

更新日期：2020-10-01 00:00:00

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:A novel antimicrobial peptide named odorranain-NR was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLSGILGAGKHIVCGLTGCAKA. Odorranain-NR was classified into a novel family of antimicrobial peptide although it shared sim...

journal_title：Peptides

authors： Che Q,Zhou Y,Yang H,Li J,Xu X,Lai R

更新日期：2008-04-01 00:00:00

abstract：:To determine if insulin-like growth factor (IGF)-1 and -2, FSH, or leptin alter IGF-binding protein (IGFBP)-2, -3, -4, and -5 mRNA levels in bovine granulosa and (or) theca cells, granulosa and theca cells were collected from bovine ovarian follicles, plated for 48 h in 10% FCS and then treated for 24 h in serum-free ...

journal_title：Peptides

authors： Voge JL,Aad PY,Santiago CA,Goad DW,Malayer JR,Allen D,Spicer LJ

更新日期：2004-12-01 00:00:00

abstract：:Urinary tract infections (UTI) are important health problems and predisposing causes of UTI are not entirely known. Neuro-immune interactions play an important role in human health and disease. Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as su...

journal_title：Peptides

authors： Altuntaş SÇ,Ipekçi T,Yakupoğlu G,Erin N

更新日期：2014-06-01 00:00:00

abstract：:The basal caeliferan family Tetrigidae is investigated to identify neuropeptides belonging to the adipokinetic hormone (AKH) family. The pygmy grasshopper Tetrix subulata contains in its corpus cardiacum two octapeptides as revealed by liquid chromatography coupled to electrospray ionization mass spectrometry. The les...

journal_title：Peptides

authors： Gäde G,Šimek P,Marco HG

更新日期：2015-06-01 00:00:00

abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...

journal_title：Peptides

authors： Malagon M,Vaudry H,Vallarino M,Gracia-Navarro F,Tonon MC

更新日期：1992-01-01 00:00:00

abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...

journal_title：Peptides

authors： Melchiorri P,Erspamer GF,Erspamer V,Guglietta A,De Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F

更新日期：1982-09-01 00:00:00

abstract：:Opioid receptor analyses of deltorphin A (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogues indicated the following: (a) increased negativity differentially affected affinities (Ki) and selectivity (Ki mu/Ki delta); (b) shifted sequence heptapeptides, [Asp5,Leu6,Met-NH2(7)] and [Asp4,His5,Leu6,Met-NH2(7)], reversed selec...

journal_title：Peptides

authors： Lazarus LH,Salvadori S,Attila M,Grieco P,Bundy DM,Wilson WE,Tomatis R

更新日期：1993-01-01 00:00:00

abstract：:In the cephalopod mollusk Octopus vulgaris, the gonadotropic hormone released by the optic gland controls sexual maturity. Several lobes of the central nervous system control the activity of this gland. In one of these lobes, the olfactory lobe, a gonadotropin releasing hormone (GnRH) neuronal system has been describe...

journal_title：Peptides

authors： Di Cristo C,De Lisa E,Di Cosmo A

更新日期：2009-03-01 00:00:00

abstract：:Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...

journal_title：Peptides

authors： Valdes-Gonzalez T,Inagawa J,Ido T

更新日期：2001-07-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00