Abstract:
:Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Distinct inhibitory activity was found in the case of thymopentin (RKDVY), the active fragment of thymopoietin. In this case the Mycobacterium phagocytosis inhibition should be combined with general immunostimulatory activity of RKDVY peptide. Our examination of a series of GRGDV analogs with a successively prolonged oligo-Gly linker inserted into the peptide chain showed that the distance between the Arg and Asp residues required for such an activity should be about 9A.
journal_name
Peptidesjournal_title
Peptidesauthors
Siemion IZ,Gawlowska M,Krajewski K,Strug I,Wieczorek Zdoi
10.1016/j.peptides.2003.07.002subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1109-15issue
8eissn
0196-9781issn
1873-5169pii
S0196978103002377journal_volume
24pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00185-4
更新日期:1996-01-01 00:00:00
abstract::Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattere...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90126-8
更新日期:1984-09-01 00:00:00
abstract::The degradation of synthetic Manduca sexta allatostatin (Manse-AS) and allatotropin (Manse-AT), by enzymes of the foregut of larvae of the tomato moth, Lacanobia oleracea was investigated using reversed-phase high performance liquid chromatography (RP-HPLC) together with matrix-assisted laser desorption ionization-tim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00189-4
更新日期:2002-11-01 00:00:00
abstract::The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positiv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90023-x
更新日期:1988-01-01 00:00:00
abstract::Peptides are important regulators of growth and cellular functions not only in normal tissue but also in tumors. So they are becoming radioligands of increasing interest in nuclear oncology for targeted tumor diagnosis and therapy. So development of new peptide radiopharmaceuticals is becoming one of the most importan...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.08.015
更新日期:2009-12-01 00:00:00
abstract::Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.001
更新日期:2006-07-01 00:00:00
abstract::Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.03.012
更新日期:2015-06-01 00:00:00
abstract::We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.11.034
更新日期:2005-10-01 00:00:00
abstract::In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. PC-12 cell...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.04.006
更新日期:2011-06-01 00:00:00
abstract::Cationic antibacterial peptides are produced in all living organisms and possess either selective activity toward a certain type of cell or microorganism, or a broad spectrum of activity toward several types of cells including prokaryotic and mammalian cells. In order to exert their activity, peptides first interact w...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2003.09.013
更新日期:2003-11-01 00:00:00
abstract::Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90170-7
更新日期:1987-01-01 00:00:00
abstract::The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90126-0
更新日期:1994-01-01 00:00:00
abstract::The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.11.007
更新日期:2013-01-01 00:00:00
abstract::Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.07.010
更新日期:2017-09-01 00:00:00
abstract::Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.002
更新日期:2003-12-01 00:00:00
abstract::Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The concentration of mature kisspeptins may not directly correlate with Kiss1 mRNA levels, because mRNA translation and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.04.013
更新日期:2013-07-01 00:00:00
abstract::Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90019-0
更新日期:1983-09-01 00:00:00
abstract::We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.08.009
更新日期:2009-12-01 00:00:00
abstract::Since its discovery, many physiologic functions have been ascribed to ghrelin, a gut derived hormone. The presence of a median fatty acid side chain on the ghrelin peptide is required for the binding and activation of the classical ghrelin receptor, the growth hormone secretagogue receptor (GHSR)-1a. Ghrelin O-acyl tr...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2011.08.020
更新日期:2011-11-01 00:00:00
abstract::The temporins are a family of hydrophobic, C-terminally alpha-amidated antimicrobial peptides that are synthesized in the skins of a wide range of species of frogs belonging to the genus Rana. In the present study, we investigated using RT-PCR the expression of preprotemporin mRNAs in extradermal tissues of Tago's bro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.03.023
更新日期:2006-09-01 00:00:00
abstract::Dihydroergotoxine (DHET) is comprised of equal part of the mesylates of dihydroergocristine, dihydroergocornine and dihydroergocryptine. In the standard radioreceptor assays, DHET components displaced the CNS-receptor binding of [3H]-enkephalin (ENK) and [3H]thyrotropin releasing hormone (TRH). The inhibitory effect o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90050-0
更新日期:1984-01-01 00:00:00
abstract::The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90151-e
更新日期:1991-07-01 00:00:00
abstract::Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.009
更新日期:2011-06-01 00:00:00
abstract::Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90073-c
更新日期:1992-05-01 00:00:00
abstract::Macrophage foam cell formation, characterized by cholesterol ester accumulation catalyzed by acyl-CoA:cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis. We previously demonstrated the suppressive effects of incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic poly...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.12.015
更新日期:2014-04-01 00:00:00
abstract::The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00068-0
更新日期:1998-01-01 00:00:00
abstract::The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90184-7
更新日期:1990-07-01 00:00:00
abstract::Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00035-6
更新日期:1996-01-01 00:00:00
abstract::This study aimed to examine the effects of CPB on salusin-α, salusin-β and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. T...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.027
更新日期:2012-10-01 00:00:00
abstract::Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.005
更新日期:2004-11-01 00:00:00