Abstract：
:We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency than the native heptapeptide, in a similar experimental set-up. Thus, Wistar male rats were made tolerant to morphine by daily injections of the opiate during 8 days. Following peptide administration (i.c.v.) and a subsequent naloxone challenge a variety of physical syndromes of withdrawal were recorded. We observed that the SP(1-7) amide potently and dose-dependently reduced several signs of reaction to morphine withdrawal. Interestingly, the effect of the peptide amide was significantly attenuated by the addition of the sigma agonist (+)-SKF-10047. We conclude that the SP(1-7) amide mimics the effect of the native SP fragment and that the mechanisms for its action involve a sigma receptor site.
journal_name
Peptidesjournal_title
Peptidesauthors
Zhou Q,Carlsson A,Botros M,Fransson R,Sandström A,Gordh T,Hallberg M,Nyberg Fdoi
10.1016/j.peptides.2009.08.009subject
Has Abstractpub_date
2009-12-01 00:00:00pages
2418-22issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(09)00344-1journal_volume
30pub_type
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