Abstract：
:The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we have described a Y1-subfamily and a Y2-subfamily receptor in the river lamprey, Lampetra fluviatilis. Here we report the identification of a Y5 receptor in the genome of the sea lamprey, Petromyzon marinus. In phylogenetic analyses, the Y5 receptor clusters together with gnathostome Y5 receptors with high bootstrap value and shares the long intracellular loop 3. This lamprey receptor has an even longer loop 3 than the gnathostome Y5 receptors described so far, with the expansion of amino acid repeats. Functional expression in a human cell line, co-transfected with a modified human G-protein, resulted in inositol phosphate turnover in response to the three lamprey NPY-family peptides NPY, PYY and PMY at nanomolar concentrations. Our results confirm that the Y1-Y2-Y5 receptor gene triplet arose before the cyclostome-gnathostome divergence. However, it is not clear from the NPY receptors whether cyclostomes diverged from the gnathostome lineage after the first or the second tetraploidization. Duplicates resulting from the tetraploidizations exist for both Y1 and Y2 in gnathostomes, but only a single copy of Y5 has survived in all vertebrates characterized to date, making the physiological roles of Y5 interesting to explore.
journal_name
Peptidesjournal_title
Peptidesauthors
Xu B,Sundström G,Kuraku S,Lundell I,Larhammar Ddoi
10.1016/j.peptides.2012.11.007subject
Has Abstractpub_date
2013-01-01 00:00:00pages
64-70eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00458-5journal_volume
39pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90061-0
更新日期：1985-03-01 00:00:00
abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2012.05.015
更新日期：2012-08-01 00:00:00
abstract：:This study presents the binding and functional properties of the mouse NPFF(2) (mNPFF(2)) receptor, in comparison with its human counterpart (hNPFF(2)). Binding experiments were performed by using the NPFF(2) selective radioligand [(3)H]-EYF in membranes from CHO cells transfected with mouse and human NPFF(2) receptor...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.020
更新日期：2010-02-01 00:00:00
abstract：:Generally, biomacromolecules, such as DNA, RNA, and proteins, cannot freely permeate into cells from outside the membrane. Protein transduction domains (PTDs) are peptides containing a large number of basic amino acids that can deliver macromolecules into living cells. Arginine-rich intracellular delivery (AID) peptid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.06.006
更新日期：2009-09-01 00:00:00
abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90071-9
更新日期：1986-01-01 00:00:00
abstract：:Pheromone biosynthesis activating neuropeptide (PBAN) produced in the subesophageal ganglion stimulates pheromone production in the pheromone gland. A cDNA isolated from female adult heads of the diamondback moth (Plutella xylostella (L.)) encodes 193 amino acids including PBAN, designated as Plx-PBAN, and four other ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.04.016
更新日期：2005-12-01 00:00:00
abstract：:In sheep, arginine vasopressin (AVP) and corticotropin-releasing factor (CRF) stimulate adrenocorticotropic hormone (ACTH) secretion. Increased hypothalamic secretion of these peptides at the end of gestation initiates parturition in this species. We hypothesized that CRF and/or AVP content in the fetal hypothalamus i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02060-8
更新日期：1996-01-01 00:00:00
abstract：:This paper reports the purification and biochemical/pharmacological characterization of two myotoxic phospholipases A(2) (PLA(2)s) from Bothrops brazili venom, a native snake from Brazil. Both myotoxins (MTX-I and II) were purified by a single chromatographic step on a CM-Sepharose ion-exchange column up to a high pur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.05.021
更新日期：2008-10-01 00:00:00
abstract：:The degradation of synthetic Manduca sexta allatostatin (Manse-AS) and allatotropin (Manse-AT), by enzymes of the foregut of larvae of the tomato moth, Lacanobia oleracea was investigated using reversed-phase high performance liquid chromatography (RP-HPLC) together with matrix-assisted laser desorption ionization-tim...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00189-4
更新日期：2002-11-01 00:00:00
abstract：:Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90161-9
更新日期：1993-11-01 00:00:00
abstract：:Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression anal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00195-9
更新日期：2000-05-01 00:00:00
abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.08.016
更新日期：2008-12-01 00:00:00
abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.08.010
更新日期：2012-11-01 00:00:00
abstract：:Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90019-0
更新日期：1983-09-01 00:00:00
abstract：:Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2018.03.018
更新日期：2018-06-01 00:00:00
abstract：:Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00044-5
更新日期：2003-02-01 00:00:00
abstract：:We recently discovered that vascular responsiveness to adrenomedullin (AM), a vasoactive hormone, decreases after hemorrhage, which is markedly improved by the addition of its binding protein AMBP-1. One obstacle hampering the development of AM/AMBP-1 as resuscitation agents in trauma victims is the potential immunoge...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.02.021
更新日期：2008-07-01 00:00:00
abstract：:An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.04.014
更新日期：2004-07-01 00:00:00
abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90219-5
更新日期：1984-03-01 00:00:00
abstract：:There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.09.005
更新日期：2011-10-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.10.022
更新日期：2008-01-01 00:00:00
abstract：:Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic beha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90121-8
更新日期：1982-05-01 00:00:00
abstract：:Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.07.012
更新日期：2011-09-01 00:00:00
abstract：:Previously, we described a gene, flp-1, that encodes seven FMRFamide-like peptides from two alternatively spliced transcripts in the nematode Caenorhabditis elegans. To determine whether all or a subset of the predicted peptides coded for by flp-1 are produced in vivo, we undertook the isolation of FMRFamide-like pept...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90049-m
更新日期：1993-03-01 00:00:00
abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.009
更新日期：2010-02-01 00:00:00
abstract：:Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90096-7
更新日期：1983-11-01 00:00:00
abstract：:The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.05.029
更新日期：2011-08-01 00:00:00
abstract：:A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90145-2
更新日期：1986-11-01 00:00:00
abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.03.003
更新日期：2013-05-01 00:00:00
