Abstract:
:Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic behavior similar to porcine antral gastrins. However, bovine pituitaries lack gastrin and contain instead substantial quantities of a peptide which co-elutes with CCK8 sulfate. We have previously shown that rat pituitary also contains CCK8 sulfate-like peptides but lacks gastrin [3]. It is clear from this work that species differences exist in the gastrin/CCK pituitary peptides. This points out the necessity of a careful chemical characterization of pituitary gastrin/CCK peptides in any species prior to physiological or pharmacological experimentation.
journal_name
Peptidesjournal_title
Peptidesauthors
Beinfeld MCdoi
10.1016/0196-9781(82)90121-8subject
Has Abstractpub_date
1982-05-01 00:00:00pages
531-4issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(82)90121-8journal_volume
3pub_type
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