The effects of MIF-I, beta-endorphin and alpha-MSH on d-amphetamine induced paradoxical behavioral thermoregulation: possible involvement of the dopaminergic system.

abstract：:The term "oxidative stress" indicates a set of chemical reactions unleashed by a disparate number of events inducing DNA damage, lipid peroxidation, protein modification and other effects, which are responsible of altering the physiological status of cells or tissues. Excessive Reactive Oxygen Species (ROS) levels may...

journal_title：Peptides

authors： Sandomenico A,Severino V,Apone F,De Lucia A,Caporale A,Doti N,Russo A,Russo R,Rega C,Del Giacco T,Falcigno L,Ruvo M,Chambery A

更新日期：2017-03-01 00:00:00

abstract：:Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remain...

journal_title：Peptides

authors： Tran L,Ha-Duong T

更新日期：2015-07-01 00:00:00

abstract：:The hypotensive effect of proadrenomedullin N-terminal 20 peptide (PAMP) was examined in conscious pregnant (8, 14, and 20 days of pregnancy) and nonpregnant rats. Intravenous administration of PAMP (3-60 nmol/kg) produced a dose-dependent depressor response in both pregnant and nonpregnant rats. However, the maximum ...

journal_title：Peptides

authors： Makino I,Makino Y,Kangawa K,Shibata K

更新日期：1999-12-01 00:00:00

abstract：:The localization of CCK8-, bombesin- and VIP-like immunoreactivities in the myenteric plexus of the guinea pig small intestine has been studied by radioimmunoassay of extracts of longitudinal muscle strips obtained with and without adherent myenteric plexus; concentrations were compared with those in other regions of ...

journal_title：Peptides

authors： Hutchison JB,Dimaline R,Dockray GJ

更新日期：1981-04-01 00:00:00

abstract：:Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats. Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats. A test of the ability of AMY to form a conditioned taste aversion yielded no change i...

journal_title：Peptides

authors： Chance WT,Balasubramaniam A,Chen X,Fischer JE

更新日期：1992-09-01 00:00:00

abstract：:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...

journal_title：Peptides

authors： Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CM

更新日期：1986-03-01 00:00:00

abstract：:The brain and the retrocerebral complex of the locust, Locusta migratoria, were examined for the presence of FMRFamide-related peptides (FaRPs) using an RIA specific for -RFamide. RP-HPLC of these extracts using both C18 and phenyl columns revealed the presence of several FaRPs eluting at different percentages of acet...

journal_title：Peptides

authors： Peeff NM,Orchard I,Lange AB

更新日期：1994-01-01 00:00:00

abstract：:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...

journal_title：Peptides

authors： Minamino N,Sudoh T,Kangawa K,Matsuo H

更新日期：1985-01-01 00:00:00

abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...

journal_title：Peptides

authors： Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

更新日期：2017-07-01 00:00:00

abstract：:Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...

journal_title：Peptides

authors： Zhang X,Lu XM,Huang LF,Li X

更新日期：2013-05-01 00:00:00

abstract：:The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100 ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10 microl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200 ng AVP or 1...

journal_title：Peptides

authors： Yang J,Song CY,Liu WY,Lin BC

更新日期：2006-12-01 00:00:00

abstract：:The present study involves the isolation and characterization of secretin-like immunoreactivity from the brains of pigs, rats and dogs. Secretin-like immunoreactivity was extracted with 0.1 N HCl and subjected to SP-Sephadex ion exchange chromatography and gel filtration on a Sephadex G-50 superfine column. The averag...

journal_title：Peptides

authors： Chang TM,Berger-Ornstein L,Chey WY

更新日期：1985-03-01 00:00:00

abstract：:This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...

journal_title：Peptides

authors： Rao KR,Riehm JP

更新日期：1988-01-01 00:00:00

abstract：:Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...

journal_title：Peptides

authors： Heidbreder C,Gewiss M,De Mot B,Mertens I,De Witte P

更新日期：1992-05-01 00:00:00

abstract：:Neuromedin B (NMB), which was originally isolated from porcine spinal cord, is a mammalian bombesin-related peptide that exerts various physiological effects. Previously, we observed expression of NMB in rib cartilage from chicken. Here, we report the initial attempt to elucidate the role of NMB in cartilage. We used ...

journal_title：Peptides

authors： Saito H,Ikeda R,Inoue K,Nagata S,Kitamura K,Minamino N,Kangawa K,Miyata A

更新日期：2012-08-01 00:00:00

abstract：:Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation of the parasitophorous vacuole (PV). The Plasmodium falciparum Pf34 protein was recently identified...

journal_title：Peptides

authors： Arévalo-Pinzón G,Curtidor H,Vanegas M,Vizcaíno C,Patarroyo MA,Patarroyo ME

更新日期：2010-11-01 00:00:00

abstract：:A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...

journal_title：Peptides

authors： Zhao J,Guo L,Zeng H,Yang X,Yuan J,Shi H,Xiong Y,Chen M,Han L,Qiu D

更新日期：2012-02-01 00:00:00

abstract：:We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...

journal_title：Peptides

authors： Wanke IE,Huang M,Rorstad OP

更新日期：1990-11-01 00:00:00

abstract：:Chicken-I and chicken-II gonadotropin-releasing hormone (cI-GnRH and cII-GnRH) were shown to be differentially distributed in the brain of a turtle, Trachemys scripta, by HPLC and specific radioimmunoassays. The cI-GnRH was most concentrated in the median eminence (ME), while cII-GnRH was most concentrated in the caud...

journal_title：Peptides

authors： Tsai PS,Licht P

更新日期：1993-03-01 00:00:00

abstract：:Evidence on the relative roles of endothelin ET(A) and ET(B) receptors in mediating the nociceptive and hyperalgesic actions of endothelin-1 is still fragmented and conflicting, due to variations between species and/or models. This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavi...

journal_title：Peptides

authors： Motta EM,Chichorro JG,D'Orléans-Juste P,Rae GA

更新日期：2009-05-01 00:00:00

abstract：:Enzyme-resistant receptor agonists of the incretin hormone glucagon-like peptide-1 (GLP-1) have shown positive therapeutic effects in people with type 2 diabetes mellitus (T2DM). T2DM has detrimental effects on brain function and impairment of cognition and memory formation has been described. One of the underlying me...

journal_title：Peptides

authors： Gault VA,Hölscher C

更新日期：2018-02-01 00:00:00

abstract：:The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10(-7) M) and the natural decapeptide [LHRH(1-10...

journal_title：Peptides

authors： Chen Y,Wong M,Moss RL

更新日期：1993-09-01 00:00:00

abstract：:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...

journal_title：Peptides

authors： Theodorsson-Norheim E

更新日期：1983-07-01 00:00:00

abstract：:The somatostatin analogs D-Phe-Cys-D-Trp-Lys-Thr-Cys-Thr and the corresponding penicillamine compounds have been prepared and tested for their ability to displace [3H]naloxone and [3H] [D-Ala2, D-Leu5]enkephalin from rat brain receptors. While somatostatin and the cystine containing peptide displayed little or no pref...

journal_title：Peptides

authors： Pelton JT,Gulya K,Hruby VJ,Duckles S,Yamamura HI

更新日期：1985-01-01 00:00:00

abstract：:Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...

journal_title：Peptides

authors： Disa J,Floyd LE,Edwards RM,Douglas SA,Aiyar NV

更新日期：2006-06-01 00:00:00

abstract：:Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...

journal_title：Peptides

authors： Williams DL,Coiduras II,Parise EM,Maske CB

更新日期：2020-11-01 00:00:00

abstract：:DDSDEEN chromatin peptide, after dansylation, was studied for its ability to bind N-CAM protein. The binding causes a quenching of the Dns-peptide fluorescence emission. Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown. Fluorescence quenching is completely lost if the Dns-peptide is subjected ...

journal_title：Peptides

authors： Marsili V,Lupidi G,Berellini G,Calzuola I,Perni S,Cruciani G,Gianfranceschi GL

更新日期：2008-12-01 00:00:00

abstract：:An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passi...

journal_title：Peptides

authors： Braszko JJ

更新日期：2004-07-01 00:00:00

abstract：:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...

journal_title：Peptides

authors： Struck J,Morgenthaler NG,Bergmann A

更新日期：2005-12-01 00:00:00

abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...

journal_title：Peptides

authors： Deng PY,Li YJ

更新日期：2005-09-01 00:00:00