Abstract:
:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and blood sampled for up to 75 minutes at one-minute intervals beginning at 1100 hr (n=6) or 1730 hr (n=4). Sporadic low-amplitude micropulses were observed at both times of day. In addition, infrequent "superpulses" were observed in the evening. Analysis of pulse parameters revealed a significant (p less than 0.001) difference in pulse amplitude but no difference in pulse frequency of interpeak interval between morning and evening. As with other episodically secreted hormones, the threshold for pulse identification and the sampling interval were found to influence the observed pulse parameters.
journal_name
Peptidesjournal_title
Peptidesauthors
Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CMdoi
10.1016/0196-9781(86)90216-0subject
Has Abstractpub_date
1986-03-01 00:00:00pages
219-23issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(86)90216-0journal_volume
7pub_type
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