Abstract:
:Enzyme-resistant receptor agonists of the incretin hormone glucagon-like peptide-1 (GLP-1) have shown positive therapeutic effects in people with type 2 diabetes mellitus (T2DM). T2DM has detrimental effects on brain function and impairment of cognition and memory formation has been described. One of the underlying mechanisms is most likely insulin de-sensitization in the brain, as insulin improves cognitive impairments and enhances learning. Treatment with GLP-1 receptor agonists improves memory formation and impairment of synaptic plasticity observed in animal models of diabetes-obesity. Furthermore, it has been shown that diabetes impairs growth factor signalling in the brain and reduces energy utilization in the cortex. Inflammation and apoptotic signalling was also increased. Treatment with GLP-1 receptor agonists improved neuronal growth and repair and reduced inflammation and apoptosis as well as oxidative stress. In comparison with the diabetes drug metformin, GLP-1 receptor agonists were able to improve glycemic control and reverse brain impairments, whereas metformin only normalized blood glucose levels. Clinical studies in non-diabetic patients with neurodegenerative disorders showed neuroprotective effects following administration with GLP-1 receptor agonists, demonstrating that neuroprotective effects are independent of blood glucose levels.
journal_name
Peptidesjournal_title
Peptidesauthors
Gault VA,Hölscher Cdoi
10.1016/j.peptides.2017.11.017subject
Has Abstractpub_date
2018-02-01 00:00:00pages
101-107eissn
0196-9781issn
1873-5169pii
S0196-9781(17)30363-7journal_volume
100pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract::In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00211-4
更新日期:2000-06-01 00:00:00
abstract::A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.07.013
更新日期:2006-12-01 00:00:00
abstract::A sparse to moderate supply of nerve fibers containing neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal polypeptide (VIP-LI), substance P (SP-LI), and calcitonin gene-related peptide (CGRP-LI) was demonstrated in the walls of human middle meningeal arteries. Comparison with similar studies on human...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90084-g
更新日期:1992-05-01 00:00:00
abstract::We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00379-5
更新日期:2001-04-01 00:00:00
abstract::Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY signi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00345-x
更新日期:2001-03-01 00:00:00
abstract::Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.04.012
更新日期:2018-06-01 00:00:00
abstract::BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170106
更新日期:2019-08-01 00:00:00
abstract::In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00164-5
更新日期:2003-06-01 00:00:00
abstract::In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.021
更新日期:2007-06-01 00:00:00
abstract::alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80126-x
更新日期:1981-10-01 00:00:00
abstract::The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.12.015
更新日期:2008-05-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.05.002
更新日期:2009-11-01 00:00:00
abstract::The brain and the retrocerebral complex of the locust, Locusta migratoria, were examined for the presence of FMRFamide-related peptides (FaRPs) using an RIA specific for -RFamide. RP-HPLC of these extracts using both C18 and phenyl columns revealed the presence of several FaRPs eluting at different percentages of acet...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90193-7
更新日期:1994-01-01 00:00:00
abstract::We have isolated TDVDHVFLRFamide (DMS), FDDYGHMRFamide (DSK), and DPKQDFMRFamide from Drosophila melanogaster. These peptides, structurally related by a common C-terminus -XRFamide, where X = L or M, are encoded by three different genes. To determine cellular expression, we have generated antisera to multiple antigeni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00279-3
更新日期:1997-01-01 00:00:00
abstract::Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.008
更新日期:2009-03-01 00:00:00
abstract::Neuropeptides related to vertebrate tachykinins have been identified in Drosophila and are referred to as drosotachykinins, or DTKs. Two Drosophila G protein-coupled receptors, designated NKD (neurokinin receptor from Drosophila; CG6515) and DTKR (Drosophila tachykinin receptor; CG7887), display sequence similarities ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.012
更新日期:2009-03-01 00:00:00
abstract::Modification to the structure of glucagon has provided a number of glucagon receptor antagonists with possible therapeutic application for diabetes. These novel peptide analogs include desHis(1)Pro(4)Glu(9)-glucagon and desHis(1)Pro(4)Glu(9)(Lys(30)PAL)-glucagon. This study has evaluated the metabolic benefits of once...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.08.002
更新日期:2014-10-01 00:00:00
abstract::Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.006
更新日期:2009-02-01 00:00:00
abstract::We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.023
更新日期:2013-06-01 00:00:00
abstract::Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90171-x
更新日期:1992-07-01 00:00:00
abstract::To characterize the endothelin (ET) receptor that mediates the contraction induced by ET-1 in the porcine myometrium, we carried out a contraction study, radioligand binding study and molecular study (reverse transcription polymerase chain reaction) for detection of ET receptor-coding genes (mRNA). ET-1 (1 nM-1 microM...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00169-8
更新日期:2000-04-01 00:00:00
abstract::The GPR103 receptor is a G protein-coupled receptor, which plays a role in several physiological functions. However, the role of the GPR103 receptor in anxiety has not been clarified. The first aim of our study was to elucidate the involvement of the GPR103 receptor in anxious behavior. Mice were treated with peptide ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Cocaine- and amphetamine regulated transcript (CART) is a recently discovered anorexigenic peptide, widely expressed in the central nervous system. Included among presumed hypothalamic mediated functions of CART are inhibition of food intake, stimulation of energy expenditure and regulation of hypothalamic-pituitary a...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.11.029
更新日期:2006-08-01 00:00:00
abstract::We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00141-7
更新日期:1999-01-01 00:00:00
abstract::We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90072-8
更新日期:1994-01-01 00:00:00
abstract::LL-37 is the single cathelicidin host defense peptide in humans with direct antimicrobial and immunomodulatory activities. Specific regulation of LL-37 synthesis has emerged as a novel non-antibiotic approach to disease control and prevention. Short-chain fatty acids, and butyrate in particular, were found recently to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.10.008
更新日期:2013-12-01 00:00:00
abstract::Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00090-7
更新日期:1995-01-01 00:00:00
abstract::Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides lowered blood pressure of spontaneously hypertensive rats (SHR)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00174-8
更新日期:2003-06-01 00:00:00
abstract::The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90057-4
更新日期:1986-01-01 00:00:00
abstract::Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00569-1
更新日期:2001-12-01 00:00:00