Insulin in the vitreous of the normal and streptozotocin-induced diabetic rat.

abstract：:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...

journal_title：Peptides

authors： Gafvelin G

更新日期：1990-07-01 00:00:00

abstract：:The reperfusion injury salvage kinase (RISK) pathway is a fundamental signal transduction cascade in the cardioprotective mechanism of ischemic postconditioning. In the present study, we examined the cardioprotective role of oxytocin as a postconditioning agent via activation of the RISK pathway (PI3K/Akt and ERK1/2)....

journal_title：Peptides

authors： Polshekan M,Jamialahmadi K,Khori V,Alizadeh AM,Saeidi M,Ghayour-Mobarhan M,Jand Y,Ghahremani MH,Yazdani Y

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to investigate how suckling influences the plasma levels of oxytocin and vasoactive intestinal peptide in lactating dogs. Blood-samples were drawn from ten lactating beagles during suckling, in week one and week three of the five week long lactation period and the levels of vasoactive ...

journal_title：Peptides

authors： Eriksson M,Lindén A,Stock S,Uvnäs-Moberg K

更新日期：1987-05-01 00:00:00

abstract：:Pretreatment with opioid antagonists enhances acquisition of Pavlovian fear conditioning. The present experiments attempted to characterize the type of opioid receptor responsible for this effect using a procedure that assessed the fear of rats to a chamber previously associated with electric shock (1 mA, 0.75 s). Fre...

journal_title：Peptides

authors： Fanselow MS,Kim JJ,Young SL,Calcagnetti DJ,DeCola JP,Helmstetter FJ,Landeira-Fernandez J

更新日期：1991-09-01 00:00:00

abstract：:Diadenosine polyphosphates (APnAs) are endogenous compounds and exert diverse cardiovascular functions. However, the effects of APnAs on atrial ANP release and contractility have not been studied. In this study, the effects of diadenosine tetraphosphate (AP4A) on atrial ANP release and contractility, and their mechani...

journal_title：Peptides

authors： Yuan K,Cao C,Bai GY,Kim SZ,Kim SH

更新日期：2007-07-01 00:00:00

abstract：:Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthesized as a precursor (prochemerin) and is proteolytically activated a...

journal_title：Peptides

authors： Shimamura K,Matsuda M,Miyamoto Y,Yoshimoto R,Seo T,Tokita S

更新日期：2009-08-01 00:00:00

abstract：:An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...

journal_title：Peptides

authors： Guo Y,Wang H,Ng TB

更新日期：2005-04-01 00:00:00

abstract：:A method has been developed for the study of somatostatin (SS) binding to dissociated cells from rat cerebral cortex. Binding of [125I] [Tyr11]SS to cells obtained by mechanical dissociation of rat cerebral cortex was dependent on time and temperature, saturable, reversible and highly specific. Under conditions of equ...

journal_title：Peptides

authors： Colas B,Prieto JC,Arilla E

更新日期：1990-11-01 00:00:00

abstract：:The role of hippocampal dynorphin A (1-8) (Dyn A (1-8)) and kappa opioid receptors was investigated in the isolation-induced hypertensive rat (IHR). Male Sprague Dawley rats were either isolated (1 per cage) or grouped (3 per cage) for 7 days. Isolated rats exhibited increased blood pressure (systolic blood pressure 1...

journal_title：Peptides

authors： Wright RC,McConnaughey MM,Ingenito AJ

更新日期：2000-12-01 00:00:00

abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...

journal_title：Peptides

authors： Ivars J,Butruille L,Knauf C,Bouckenooghe T,Mayeur S,Vieau D,Valet P,Deruelle P,Lesage J

更新日期：2012-05-01 00:00:00

abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...

journal_title：Peptides

authors： Chang CL,Roh J,Hsu SY

更新日期：2004-10-01 00:00:00

abstract：:In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...

journal_title：Peptides

authors： Nakajima T,Yasuhara T,Uzu S,Wakamatsu K,Miyazawa T,Fukuda K,Tsukamoto Y

更新日期：1985-01-01 00:00:00

abstract：:Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...

journal_title：Peptides

authors： Wewer Albrechtsen NJ

更新日期：2018-02-01 00:00:00

abstract：:Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K(m) of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]Ang II transport was foun...

journal_title：Peptides

authors： Rose JM,Audus KL

更新日期：1998-01-01 00:00:00

abstract：:Macrophage foam cell formation, characterized by cholesterol ester accumulation catalyzed by acyl-CoA:cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis. We previously demonstrated the suppressive effects of incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic poly...

journal_title：Peptides

authors： Tashiro Y,Sato K,Watanabe T,Nohtomi K,Terasaki M,Nagashima M,Hirano T

更新日期：2014-04-01 00:00:00

abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...

journal_title：Peptides

authors： Zetler G

更新日期：1985-01-01 00:00:00

abstract：:Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...

journal_title：Peptides

authors： Ott MC,Costain WJ,Mishra RK,Johnson RL

更新日期：2000-02-01 00:00:00

abstract：:[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...

journal_title：Peptides

authors： D'Souza MM,Carr JA

更新日期：1998-01-01 00:00:00

abstract：:The distribution of galanin-like immunoreactivity in the brain of the dogfish Scyliorhinus canicula was investigated using the indirect immunofluorescence technique. In the telencephalon, positive cells and fibers were located in the mid-caudal part of the area superficialis basalis, the n. septi caudoventralis and in...

journal_title：Peptides

authors： Vallarino M,Feuilloley M,Vandesande F,Vaudry H

更新日期：1991-03-01 00:00:00

abstract：:Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...

journal_title：Peptides

authors： Houpt TA,Corp ES,Berlin R

更新日期：1998-01-01 00:00:00

abstract：:The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

journal_title：Peptides

authors： Magoul R,Onteniente B,Benjelloun W,Tramu G

更新日期：1993-03-01 00:00:00

abstract：:The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...

journal_title：Peptides

authors： Currie PJ,Coscina DV

更新日期：1995-01-01 00:00:00

abstract：:Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Usi...

journal_title：Peptides

authors： Kumar P,Arise KK,Pandey KN

更新日期：2006-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...

journal_title：Peptides

authors： Aldegunde M,Mancebo M

更新日期：2006-04-01 00:00:00

abstract：:To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...

journal_title：Peptides

authors： Hartmann A,Dietl T,Krumrey K,Vogl L,Dirlich G,Holsboer F,Heuser-Link M

更新日期：1995-01-01 00:00:00

abstract：:Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...

journal_title：Peptides

authors： Poels J,Verlinden H,Fichna J,Van Loy T,Franssens V,Studzian K,Janecka A,Nachman RJ,Vanden Broeck J

更新日期：2007-01-01 00:00:00

abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...

journal_title：Peptides

authors： Davis J,Jones A,Lewis RJ

更新日期：2009-07-01 00:00:00

abstract：:Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...

journal_title：Peptides

authors： Abdelalim EM,Takada T,Torii R,Tooyama I

更新日期：2006-07-01 00:00:00

abstract：:Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...

journal_title：Peptides

authors： Micevych PE,Elde RP

更新日期：1982-07-01 00:00:00

abstract：:In this Festschrift, I discuss the career and guiding principles to which Abba J. Kastin has adhered during the last 20 years we worked together. I briefly describe the history of our joint laboratory group, the context of studies of peptide permeation across the blood-brain barrier (BBB), and newer developments in th...

journal_title：Peptides

authors： Pan W

更新日期：2015-10-01 00:00:00