Animals models of MCH function and what they can tell us about its role in energy balance.

abstract：:Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

journal_title：Peptides

authors： Dees WL,Kozlowski GP

更新日期：1984-01-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...

journal_title：Peptides

authors： Improta G,Broccardo M

更新日期：1988-07-01 00:00:00

abstract：:This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of "positive addictive" p...

journal_title：Peptides

authors： Bodnar RJ

更新日期：2019-06-01 00:00:00

abstract：:The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass spectrometry in samples containing the brain, the subesophageal ganglion, the corpora cardiaca-corpus a...

journal_title：Peptides

authors： Settembrini BP,de Pasquale D,Postal M,Pinto PM,Carlini CR,Villar MJ

更新日期：2011-03-01 00:00:00

abstract：:Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...

journal_title：Peptides

authors： Recant L,Voyles NR,Luciano M,Pert CB

更新日期：1980-01-01 00:00:00

abstract：:Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...

journal_title：Peptides

authors： Li A,Rinehart JP,Denlinger DL

更新日期：2009-03-01 00:00:00

abstract：:As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...

journal_title：Peptides

authors： Lu J,Zhang K,Wang S,Sun T,Yu S,Dai Q,Liu Z

更新日期：2017-08-01 00:00:00

abstract：:More than 40 peptides belonging to the -Y/FXFGL-NH(2) allatostatin superfamily have been isolated and identified from the central nervous system (CNS) of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea). The peptides can be arranged in seven sub-groups according to the variable post-tyrosyl residue represented ...

journal_title：Peptides

authors： Duve H,Johnsen AH,Scott AG,Thorpe A

更新日期：2002-06-01 00:00:00

abstract：:Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...

journal_title：Peptides

authors： Nicholls MG,Lainchbury JG,Lewis LK,McGregor DO,Richards AM,Troughton RW,Yandle TG

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...

journal_title：Peptides

authors： Onishi S,Kaji T,Yamada W,Nakame K,Machigashira S,Kawano M,Yano K,Harumatsu T,Yamada K,Masuya R,Kawano T,Mukai M,Hamada T,Souda M,Yoshioka T,Tanimoto A,Ieiri S

更新日期：2018-08-01 00:00:00

abstract：:Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...

journal_title：Peptides

authors： Sedra L,Lange AB

更新日期：2014-03-01 00:00:00

abstract：:A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known proteins and peptides and a molecular mass of 8kDa, was isolated from seeds of the green chickpea Cicer arietinum cv green chickpea. Cicerarin was isolated with a procedure that involved ion exchange chrom...

journal_title：Peptides

authors： Chu KT,Liu KH,Ng TB

更新日期：2003-05-01 00:00:00

abstract：:Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...

journal_title：Peptides

authors： Duque HM,Mourão CBF,Tibery DV,Barbosa EA,Campos LA,Schwartz EF

更新日期：2017-09-01 00:00:00

abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...

journal_title：Peptides

authors： Morley JE,Levine AS,Gosnell BA,Mitchell JE,Krahn DD,Nizielski SE

更新日期：1985-01-01 00:00:00

abstract：:The guinea pig ileum possesses NK-1 and NK-3 tachykinin receptors. As expected, [Pro9]SP and senktide, which are selective agonists of NK-1 and NK-3 receptors, respectively, were found to be highly potent in contracting the guinea pig ileum. Surprisingly, similar observations were made with septide, SP-O-CH3, [Apa9-10...

journal_title：Peptides

authors： Petitet F,Saffroy M,Torrens Y,Lavielle S,Chassaing G,Loeuillet D,Glowinski J,Beaujouan JC

更新日期：1992-03-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). METHODS:Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anestheti...

journal_title：Peptides

authors： Yuan K,Kim SY,Oh YB,Yu J,Shah A,Park BH,Kim SH

更新日期：2010-07-01 00:00:00

abstract：:[3H]Neurotensin (NT) was found to bind specifically and with high affinity to crude membranes prepared from rat uterus. Scatchard analysis of saturation binding studies indicated that [3H]NT apparently binds to two sites (high affinity Kd 0.5 nM; low affinity Kd 9 nM) with the density of high affinity sites (41 fmoles...

journal_title：Peptides

authors： Pettibone DJ,Totaro JA

更新日期：1987-11-01 00:00:00

abstract：:The pineal nonapeptide hormone arginine vasotocin (AVT) (100 ng/kg) administered intra-nasally (IN) to healthy prepubertal boys, dramatically increased the amount of REM sleep, decreased REM sleep latency, and induced REM periods at sleep onset. Neither arginine vasopressin (AVP) nor oxytocin administered IN at the do...

journal_title：Peptides

authors： Pavel S,Goldstein R,Petrescu M,Popa M

更新日期：1981-10-01 00:00:00

abstract：:ZP120 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) ligand. In previous studies, the effects of ZP120 were found to be sensitive to J-113397 in mouse tissues while resistant to UFP-101 in rat tissues. The aim of this study was to further investigate the ZP120 pharmacological profile using mouse and rat pr...

journal_title：Peptides

authors： Fischetti C,Rizzi A,Gavioli EC,Marzola G,Trapella C,Guerrini R,Petersen JS,Calo G

更新日期：2009-02-01 00:00:00

abstract：:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...

journal_title：Peptides

authors： Cebrat M,Wieczorek Z,Siemion IZ

更新日期：1996-01-01 00:00:00

abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...

journal_title：Peptides

authors： Fein E,Merle U,Ehehalt R,Herrmann T,Kulaksiz H

更新日期：2007-05-01 00:00:00

abstract：:Nonmammalian peptides of the tachykinin, bombesin and opioid families, injected into the brain ventricles, potently and specifically affect drinking behaviour of rats and pigeons. These peptides, or at least their counterparts, have been found in the brain of mammals and birds. It has been hypothesized that these endo...

journal_title：Peptides

authors： de Caro G,Massi M

更新日期：1985-01-01 00:00:00

abstract：:In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance ...

journal_title：Peptides

authors： De Giorgio R,Arakawa J,Wetmore CJ,Sternini C

更新日期：2000-09-01 00:00:00

abstract：:We are interested in the presence and function in insects of neuropeptides related to the vertebrate tachykinins. Hence, we have used antisera raised against the tachykinins substance P and kassinin, and against the insect neuropeptide leucokinin I, for localization studies and immunochemical analysis of related pepti...

journal_title：Peptides

authors： Lundquist CT,Brodin E,Muren JE,Nässel DR

更新日期：1993-07-01 00:00:00

abstract：:NLP-12a and b have been identified as cholecystokinin/sulfakinin-like neuropeptides in the free-living nematode Caenorhabditis elegans. They are suggested to play an important role in the regulation of digestive enzyme secretion and fat storage. This study reports on the identification and characterization of an NLP-1...

journal_title：Peptides

authors： Peeters L,Janssen T,De Haes W,Beets I,Meelkop E,Grant W,Schoofs L

更新日期：2012-03-01 00:00:00

abstract：:One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...

journal_title：Peptides

authors： Guo CT,McClean S,Shaw C,Rao PF,Ye MY,Bjourson AJ

更新日期：2013-05-01 00:00:00

abstract：:Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...

journal_title：Peptides

authors： Chakrabarti AK,Chatterjee TK,Ghosh JJ

更新日期：1983-05-01 00:00:00

abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...

journal_title：Peptides

authors： Ruellan C,Scemama JL,Clerc P,Fagot-Revurat P,Clemente F,Ribet A

更新日期：1986-01-01 00:00:00