Multiple antigenic peptides designed to structurally related Drosophila peptides.

abstract：:The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...

journal_title：Peptides

authors： Geraghty RF,Irvine GB,Williams CH,Cottrell GA

更新日期：1994-01-01 00:00:00

abstract：:We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...

journal_title：Peptides

authors： Greco MC,Lisi L,Currò D,Navarra P,Tringali G

更新日期：2014-06-01 00:00:00

abstract：:Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...

journal_title：Peptides

authors： Unniappan S,Speck M,Kieffer TJ

更新日期：2008-08-01 00:00:00

abstract：:Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia. Yet, data on hepcidin status in dementia are scanty, limited to Alzheimer's disease (AD) and inconsistent due to methodological problems with its determination using immunoassays and/or lack of homoge...

journal_title：Peptides

authors： Fleszar MG,Wiśniewski J,Berdowska I,Zieliński B,Zboch M,Diakowska D,Gamian A,Krzystek-Korpacka M

更新日期：2019-12-01 00:00:00

abstract：:Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin. These results suggest that caudate nucleus plays an inhibitory role in controlling the cataleptic response...

journal_title：Peptides

authors： Improta G,Guglietta A

更新日期：1985-01-01 00:00:00

abstract：:The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...

journal_title：Peptides

authors： Flanagan-Cato LM,Moga CN,Fluharty SJ

更新日期：1996-01-01 00:00:00

abstract：:Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrang...

journal_title：Peptides

authors： Gopalakrishnan S,Tripathi A,Tamiz AP,Alkan SS,Pandey NB

更新日期：2012-05-01 00:00:00

abstract：:Glucagon-related peptides such as glucagon, glucagon-like peptide-1, and oxyntomodulin suppress food intake in mammals and birds. Recently, novel glucagon-like peptide (GCGL) was identified from chicken brain, and a comparatively high mRNA expression level of GCGL was detected in the hypothalamus. A number of studies ...

journal_title：Peptides

authors： Honda K,Saneyasu T,Yamaguchi T,Shimatani T,Aoki K,Nakanishi K,Kamisoyama H

更新日期：2014-02-01 00:00:00

abstract：:Oxytocin receptors have recently been demonstrated in human osteoblast-like (hOB) cells. In this study, oxytocin 100-1000 pmol/l increased cell proliferation of primary cultures of hOB cells, measured by [3H]thymidine incorporation, (P<0.01). In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell...

journal_title：Peptides

authors： Petersson M,Lagumdzija A,Stark A,Bucht E

更新日期：2002-06-01 00:00:00

abstract：:In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...

journal_title：Peptides

authors： Li W,Zheng S,Tang C,Zhu Y,Wang X

更新日期：2007-06-01 00:00:00

abstract：:Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...

journal_title：Peptides

authors： Sciani JM,Sampaio MC,Zychar BC,Gonçalves LR,Giorgi R,Nogueira Tde O,de Melo RL,Teixeira Cde F,Pimenta DC

更新日期：2014-03-01 00:00:00

abstract：:The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...

journal_title：Peptides

authors： Scallet AC

更新日期：1982-03-01 00:00:00

abstract：:In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...

journal_title：Peptides

authors： Yu Y,Shao X,Wang CL,Liu HM,Cui Y,Fan YZ,Liu J,Wang R

更新日期：2007-04-01 00:00:00

abstract：:Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...

journal_title：Peptides

authors： Hikosaka T,Tsuruda T,Nagata S,Kuwasako K,Tsuchiya K,Hoshiko S,Inatsu H,Chijiiwa K,Kitamura K

更新日期：2011-09-01 00:00:00

abstract：:Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...

journal_title：Peptides

authors： Recant L,Voyles NR,Luciano M,Pert CB

更新日期：1980-01-01 00:00:00

abstract：:The effects of Pro-Leu-Gly-NH2 (melanotropin release inhibiting factor, MIF) and its analog, cyclo (Leu-Gly) on the mouse and rat striatal cholinergic muscarinic receptors labeled with 3H-quinuclidinyl benzilate (QNB) were investigated. 3H-QNB bound to the rat striatal muscarinic receptors at a single high affinity si...

journal_title：Peptides

authors： Das S,Matwyshyn GA,Bhargava HN

更新日期：1986-01-01 00:00:00

abstract：:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...

journal_title：Peptides

authors： Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DH

更新日期：1981-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART aff...

journal_title：Peptides

authors： Drott CJ,Norman D,Espes D

更新日期：2021-01-01 00:00:00

abstract：:Besides its well known endocrinological effects, thyrotropin-releasing hormone (TRH) has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders. The aim of this study was to assess if transdermal delivery of TRH and its analogue, M-TRH, in the presence of enhancers, i...

journal_title：Peptides

authors： Magnusson BM,Koskinen LO,Koch M,Karlsson K

更新日期：2001-01-01 00:00:00

abstract：:Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...

journal_title：Peptides

authors： Chakrabarti AK,Chatterjee TK,Ghosh JJ

更新日期：1983-05-01 00:00:00

abstract：:Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...

journal_title：Peptides

authors： Kunesová G,Hlavácek J,Patocka J,Evangelou A,Zikos C,Benaki D,Paravatou-Petsotas M,Pelecanou M,Livaniou E,Slaninova J

更新日期：2008-11-01 00:00:00

abstract：:Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and the related hormone glucagon-like pepti...

journal_title：Peptides

authors： Gabe MBN,van der Velden WJC,Smit FX,Gasbjerg LS,Rosenkilde MM

更新日期：2020-03-01 00:00:00

abstract：:Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...

journal_title：Peptides

authors： Abdelalim EM,Takada T,Torii R,Tooyama I

更新日期：2006-07-01 00:00:00

abstract：:The distribution of FMRFamide-like-immunoreactive peptides was investigated in the brain and pituitary of the elasmobranch fish Scyliorhinus canicula using the indirect immunofluorescence technique. FMRFamide-immunoreactive cells and fibers were mainly observed in the telencephalon and the diencephalon, while other br...

journal_title：Peptides

authors： Vallarino M,Salsotto-Cattaneo MT,Feuilloley M,Vaudry H

更新日期：1991-11-01 00:00:00

abstract：:Antimicrobial peptides allegedly exert their action on microbial membranes. Bovine lactoferrin enfold two antimicrobial domains, lactoferricin B (LFcin B) and lactoferrampin (LFampin). Effects of representative peptides thereof on the membranes of Candida albicans and Escherichia coli were investigated. Confocal laser...

journal_title：Peptides

authors： van der Kraan MI,van Marle J,Nazmi K,Groenink J,van 't Hof W,Veerman EC,Bolscher JG,Nieuw Amerongen AV

更新日期：2005-09-01 00:00:00

abstract：:Most small peptide hormones and neurotransmitters are highly flexible, conformationally labile molecules in aqueous and other environments. Thus efforts to determine the relationships between conformational properties of these peptides in aqueous and other solvents and their biological activities at membrane receptors...

journal_title：Peptides

authors： Hruby VJ,Mosberg HI

更新日期：1982-05-01 00:00:00

abstract：:The melanocortin system has been implicated in a multitude of physiological pathways including obesity, satiety, energy homeostasis, sexual behavior, pigmentation, sodium regulation, hypertension, and many others. Based upon studies of the endogenous melanocortin receptor agonists at the cloned human melanocortin rece...

journal_title：Peptides

authors： Joseph CG,Yao H,Scott JW,Sorensen NB,Marnane RN,Mountjoy KG,Haskell-Luevano C

更新日期：2010-12-01 00:00:00

abstract：:We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...

journal_title：Peptides

authors： Ekman R,Salford L,Brun A,Larsson I

更新日期：1990-03-01 00:00:00

abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...

journal_title：Peptides

authors： Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra H

更新日期：2007-10-01 00:00:00

abstract：:The first member of the periviscerokinin peptide family in Locusta migratoria was identified by post-source decay fragmentation on a MALDI-TOF mass spectrometer using a single neurohemal organ only. The primary sequence of this decapeptide, code-named Lom-PVK, is Ala-Ala-Gly-Leu-Phe-Gln-Phe-Pro-Arg-Val-NH(2). Unlike t...

journal_title：Peptides

authors： Predel R,Gäde G

更新日期：2002-04-01 00:00:00