Abstract：
:Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidinyl benzilate (QNB) in mice or rats in vivo using the Y-maze or multiple T-maze tests. This paper describes the activity of new peptides of the HN family, after i.p. administration, on QNB-induced impairment of spatial memory in the multiple T-maze test in rats. The following peptides have been studied: HN analogues truncated either on the C- or N-terminus, or analogues having a tert-Leu in place of Leu in the central part of the molecule, the active HN core PAGASRLLLLTGEIDLP (RG-PAGA) and its analogues having three or five leucines instead of four, and finally the recently described hybrid peptide colivelin (i.e. a peptide having the activity-dependent neurotrophic factor SALLRSIPA attached to the N-terminus of the active RG-PAGA) and its des-Leu- and plus-Leu-analogues. While the truncated analogues and most of the tert-Leu containing analogues were devoid of activity, the analogues of the RG-PAGA were active, i.e. they reversed the impairment of spatial memory irrespective of the number of Leu present in their sequence. The highest activity was shown by colivelin and its des-Leu-analogue. These results demonstrate the potential of HN analogues in the modulation of the cholinergic system, which plays an important role in the cognitive deficits associated with AD and other neurodegenerative diseases.
journal_name
Peptidesjournal_title
Peptidesauthors
Kunesová G,Hlavácek J,Patocka J,Evangelou A,Zikos C,Benaki D,Paravatou-Petsotas M,Pelecanou M,Livaniou E,Slaninova Jdoi
10.1016/j.peptides.2008.06.019subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1982-7issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(08)00280-5journal_volume
29pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90057-8
更新日期：1983-07-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.10.022
更新日期：2008-01-01 00:00:00
abstract：:The effect of peripheral injections of substance P (SP) on performance in two different configurations of an automated tunnel maze was examined in three experiments. In two experiments, the effect of pretrial SP injections (10-1000 micrograms/kg) on performance in the hexagonal and radial maze configuration of an auto...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90014-8
更新日期：1993-01-01 00:00:00
abstract：:Amylin is a peptide hormone secreted from the beta cells of the pancreatic islets. Amylin was administered peripherally or centrally following weak or strong training on footshock avoidance conditioning in a T-maze. Under conditions of weak training, amylin improved memory retention in a dose-dependent manner. Under c...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90092-h
更新日期：1992-05-01 00:00:00
abstract：:The cholecystokinin receptor-type 1 (CCK1R) is a G-protein coupled receptor localized in the animal gastrointestinal tract. Receptor activation by the natural peptide ligand CCK leads to a feeling of satiety. In this study, hydrolysates from soy and milk proteins were evaluated for their potential to activate the CCK1...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.11.019
更新日期：2012-03-01 00:00:00
abstract：:A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90149-0
更新日期：1988-05-01 00:00:00
abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90116-0
更新日期：1985-05-01 00:00:00
abstract：:Receptors for neuropeptide Y (NPY) and peptide YY (PYY) have been extensively characterized in the brain. Less is known about NPY receptor subtypes in the spleen, though it is well established that NPY produces vascular contraction in this tissue. In the present study, we found an unusually high density of Y1 receptor...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(96)00228-8
更新日期：1996-01-01 00:00:00
abstract：:Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.06.014
更新日期：2007-01-01 00:00:00
abstract：:The effect of caseinomacropeptide (CMP) (the [106-169] fragment of kappa-casein produced during digestion of milk protein), was studied in anesthetized rats using bile diversion for a pure pancreatic juice collection system. Intraduodenal administration of CMP induced a dose-related specific stimulation of pancreatic ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00307-7
更新日期：2000-10-01 00:00:00
abstract：:125I-Ang I binding to atypical sites on Mycoplasma hyorhinis-contaminated IEC-18 cell membranes increased with increasing pH and [NaCl] (ED50 at 500 mM; maximal 13-fold increase at 2 M NaCl). Alkali metal chlorides and sodium halides increased binding with rank orders of Na+ < K+ < Rb+ < Cs+ = Li+ and F- < Cl- < Br < ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00163-6
更新日期：1999-01-01 00:00:00
abstract：:VIP stimulates adenylate cyclase activity of male and female rat anterior pituitaries and human prolactinomas, while dopamine inhibits the enzyme activity of female rat pituitaries and prolactinomas. A dopamine inhibited cyclase can be detected also in male rats provided the enzyme activity is increased by VIP. The an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90172-4
更新日期：1984-11-01 00:00:00
abstract：:The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked ra...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80099-x
更新日期：1981-01-01 00:00:00
abstract：:The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00068-0
更新日期：1998-01-01 00:00:00
abstract：:Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats. Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats. A test of the ability of AMY to form a conditioned taste aversion yielded no change i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90057-a
更新日期：1992-09-01 00:00:00
abstract：:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90011-q
更新日期：1992-11-01 00:00:00
abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.08.016
更新日期：2008-12-01 00:00:00
abstract：:Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90166-4
更新日期：1985-07-01 00:00:00
abstract：:Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide), we have isolated the peptide Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide) from an extract of the sea anemone Anthopleura elegantissima. Antho-RPamide is located in neurons of sea anemones. Application of low concentrations of An...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90040-a
更新日期：1992-09-01 00:00:00
abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.04.001
更新日期：2016-05-01 00:00:00
abstract：:Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia. Yet, data on hepcidin status in dementia are scanty, limited to Alzheimer's disease (AD) and inconsistent due to methodological problems with its determination using immunoassays and/or lack of homoge...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.170169
更新日期：2019-12-01 00:00:00
abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00211-4
更新日期：2000-06-01 00:00:00
abstract：:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(96)00294-x
更新日期：1997-01-01 00:00:00
abstract：:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02123-x
更新日期：1996-01-01 00:00:00
abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00372-0
更新日期：1998-01-01 00:00:00
abstract：:As we commemorate the 25th anniversary of the journal Peptides, it is timely to review the functional significance of the bombesin (BB)-like peptides and receptors in the CNS. Over two decades ago we published an article in the journal Peptides demonstrating that BB-like peptides are present in high densities in certa...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.02.012
更新日期：2004-03-01 00:00:00
abstract：:Leptin, a hormone secreted by the adipocytes and involved in feeding and energy balance control, has been proposed to modulate alcohol craving in mice and humans. This study evaluated whether leptin modulates alcohol intake in Marchigian Sardinian alcohol-preferring (msP) rats. Rats were offered 10% ethanol either 2h ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.09.008
更新日期：2003-09-01 00:00:00
abstract：:An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170328
更新日期：2020-08-01 00:00:00
abstract：:The antinociceptive effect of i.t.-administered Tyr-d-Arg-Phe-β-Ala (TAPA), an N-terminal tetrapeptide analog of dermorphin, was characterized in ddY mice. In the mouse tail-flick test, TAPA administered i.t. produced a potent antinociception. The antinociception induced by TAPA was significantly attenuated by i.t. pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00164-5
更新日期：2003-06-01 00:00:00
