Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implications.

abstract：:This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...

journal_title：Peptides

authors： Gäde G,Simek P,Marco HG

更新日期：2009-03-01 00:00:00

abstract：:Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...

journal_title：Peptides

authors： Lin C,Wang N,Shen ZP,Zhao ZY

更新日期：2013-04-01 00:00:00

abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...

journal_title：Peptides

authors： Wheway J,Herzog H,Mackay F

更新日期：2007-02-01 00:00:00

abstract：:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...

journal_title：Peptides

authors： Struck J,Morgenthaler NG,Bergmann A

更新日期：2005-12-01 00:00:00

abstract：:Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...

journal_title：Peptides

authors： Bernardes CP,Santos NAG,Sisti FM,Ferreira RS,Santos-Filho NA,Cintra ACO,Cilli EM,Sampaio SV,Santos AC

更新日期：2018-06-01 00:00:00

abstract：:125I-Ang I binding to atypical sites on Mycoplasma hyorhinis-contaminated IEC-18 cell membranes increased with increasing pH and [NaCl] (ED50 at 500 mM; maximal 13-fold increase at 2 M NaCl). Alkali metal chlorides and sodium halides increased binding with rank orders of Na+ < K+ < Rb+ < Cs+ = Li+ and F- < Cl- < Br < ...

journal_title：Peptides

authors： Smith RD

更新日期：1999-01-01 00:00:00

abstract：:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...

journal_title：Peptides

authors： Britz FC,Deitmer JW

更新日期：2002-12-01 00:00:00

abstract：:A simple and computationally nonintensive technique based on principal component analysis of 3-dimensional fields to derive theoretical descriptors is presented. The descriptors are then applied to a quantitative structure-activity relationship study on bradykinin potentiating pentapeptides. ...

journal_title：Peptides

authors： Norinder U

更新日期：1991-11-01 00:00:00

abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...

journal_title：Peptides

authors： Benter IF,Diz DI,Ferrario CM

更新日期：1993-07-01 00:00:00

abstract：:Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...

journal_title：Peptides

authors： Postal M,Martinelli AH,Becker-Ritt AB,Ligabue-Braun R,Demartini DR,Ribeiro SF,Pasquali G,Gomes VM,Carlini CR

更新日期：2012-11-01 00:00:00

abstract：:The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass spectrometry in samples containing the brain, the subesophageal ganglion, the corpora cardiaca-corpus a...

journal_title：Peptides

authors： Settembrini BP,de Pasquale D,Postal M,Pinto PM,Carlini CR,Villar MJ

更新日期：2011-03-01 00:00:00

abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...

journal_title：Peptides

authors： Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MA

更新日期：2010-07-01 00:00:00

abstract：:Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sl...

journal_title：Peptides

authors： Gais S,Sommer M,Fischer S,Perras B,Born J

更新日期：2002-03-01 00:00:00

abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...

journal_title：Peptides

authors： Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra H

更新日期：2007-10-01 00:00:00

abstract：:In order to study a possible direct action of LH-RH analogs on the pituitary lactotrophs, we investigated the effect of long-term in vivo pretreatment with D-Trp-6-LH-RH on in vitro secretion of PRL and luteinizing hormone (LH) by the pituitary glands from male and female rats. In vivo pretreatment with D-Trp-6-LH-RH ...

journal_title：Peptides

authors： Torres-Alemán I,Debeljuk L,Schally AV

更新日期：1985-09-01 00:00:00

abstract：:As part of a continuing search for potential anticancer drug candidates from antimicrobial peptides of marine organisms, tilapia (Oreochromis mossambicus) hepcidin TH2-3 was evaluated in several tumor cell lines. The results indicated that TH2-3, a synthetic 20-mer antimicrobial peptide, specifically inhibited human f...

journal_title：Peptides

authors： Chen JY,Lin WJ,Lin TL

更新日期：2009-09-01 00:00:00

abstract：:A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...

journal_title：Peptides

authors： Wang SY,Wu JH,Ng TB,Ye XY,Rao PF

更新日期：2004-08-01 00:00:00

abstract：:Intraperitoneal (i.p.) administration of the synthetic agonist of the glucagon like peptide-1 (GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral pathways for this reduction. Exenatide (0.5 μg/kg, i.p.) was given to three, overnight food-deprived, groups of rats: total subdiaphragmat...

journal_title：Peptides

authors： Hunt JV,Washington MC,Sayegh AI

更新日期：2012-02-01 00:00:00

abstract：:Plasma adrenomedullin (AM) levels are elevated in various pathological states including cardiovascular and inflammatory diseases. The present study investigated whether an increased AM level is a marker of vascular complications in patients with atherosclerotic risks. In 114 patients with cardiovascular risks and/or d...

journal_title：Peptides

authors： Suzuki Y,Horio T,Nonogi H,Hayashi T,Kitamura K,Eto T,Kangawa K,Kawano Y

更新日期：2004-08-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...

journal_title：Peptides

authors： Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

更新日期：1994-01-01 00:00:00

abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

journal_title：Peptides

authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

更新日期：2007-03-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...

journal_title：Peptides

authors： Zhang S,Guo H,Shi F,Wang H,Li L,Jiao X,Wang Y,Yu H

更新日期：2012-02-01 00:00:00

abstract：:Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...

journal_title：Peptides

authors： Heyliger SO,Payza K,Rothman RB

更新日期：1998-01-01 00:00:00

abstract：:Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...

journal_title：Peptides

authors： Scallet AC,Della-Fera MA,Baile CA

更新日期：1985-09-01 00:00:00

abstract：:Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...

journal_title：Peptides

authors： Song DD,Rossier J,Harlan RE

更新日期：1989-11-01 00:00:00

abstract：:A linear peptide containing two reduced cysteine residues can be rapidly converted to its oxidized cyclic form containing an intramolecular disulfide bond by adding an excess of 2,2'-bispyridyl disulfide (2,2'-dipyridyl disulfide or 2,2'-dithiodipyridine) to conventional buffer solutions. The reactants and products ar...

journal_title：Peptides

authors： Maruyama K,Nagasawa H,Suzuki A

更新日期：1999-01-01 00:00:00

abstract：:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...

journal_title：Peptides

authors： Horodyski FM,Bhatt SR,Lee KY

更新日期：2001-02-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00

abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...

journal_title：Peptides

authors： Schwartz GJ,Moran TH,McHugh PR

更新日期：1990-11-01 00:00:00