Isolation and characterization of a variant form of vasoactive intestinal polypeptide.

abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...

journal_title：Peptides

authors： Wheway J,Herzog H,Mackay F

更新日期：2007-02-01 00:00:00

abstract：:Although several low amphipathic peptides have been known to exhibit antimicrobial activity, their mode of action has not been completely elucidated. In this study, using designed low amphipathic peptides that retain different alpha-helical content and hydrophobicity, we attempted to investigate the mechanism of these...

journal_title：Peptides

authors： Yamamoto N,Tamura A

更新日期：2010-05-01 00:00:00

abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...

journal_title：Peptides

authors： Morley JE,Levine AS,Gosnell BA,Mitchell JE,Krahn DD,Nizielski SE

更新日期：1985-01-01 00:00:00

abstract：:The puromycin-sensitive aminopeptidase (ApPS) is a zinc metallopeptidase involved in the degradation of neuropeptides. Putative catalytic residues of the enzyme, Cys146, Glu338, and Lys396 were mutated, and the resultant mutant enzymes characterized. ApPS C146S exhibited normal catalytic activity, ApPS E338A exhibited...

journal_title：Peptides

authors： Thompson MW,Hersh LB

更新日期：2003-09-01 00:00:00

abstract：:Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...

journal_title：Peptides

authors： Dillen S,Verdonck R,Zels S,Van Wielendaele P,Vanden Broeck J

更新日期：2014-03-01 00:00:00

abstract：:Short cell penetrating peptides (CPP) are widely used in vitro to transduce agents into cells. But their systemic effect has not been yet studied in detail. We studied the systemic effect of the cell penetrating peptides, penetratin, transportan and pro-rich, on rat hemodynamic functions. Intra-arterial monitoring of ...

journal_title：Peptides

authors： Basheer M,Schwalb H,Shefler I,Levdansky L,Mekori YA,Gorodetsky R

更新日期：2011-12-01 00:00:00

abstract：:An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...

journal_title：Peptides

authors： Ling R,Dai Y,Huang B,Huang W,Yu J,Lu X,Jiang Y

更新日期：2020-08-01 00:00:00

abstract：:Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...

journal_title：Peptides

authors： Shi JB,Guo ZF,Zheng X,Wang ZB,Ma YJ

更新日期：2012-12-01 00:00:00

abstract：:Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic functio...

journal_title：Peptides

authors： Jin GF,Guo YS,Smith ER,Houston CW

更新日期：1990-03-01 00:00:00

abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...

journal_title：Peptides

authors： Fein E,Merle U,Ehehalt R,Herrmann T,Kulaksiz H

更新日期：2007-05-01 00:00:00

abstract：:This mass spectrometric study confines itself to peptide masses in the range of 500-1500Da. Adipokinetic hormones (AKHs) that are predicted from the genome of the red flour beetle, Tribolium castaneum, and the silk moth, Bombyx mori, are shown to exist as expressed peptides in the corpora cardiaca (CC) of the respecti...

journal_title：Peptides

authors： Gäde G,Marco HG,Simek P,Audsley N,Clark KD,Weaver RJ

更新日期：2008-07-01 00:00:00

abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...

journal_title：Peptides

authors： Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

更新日期：1991-11-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified. The mutant, called long bone abnormality (lbab), cont...

journal_title：Peptides

authors： Yoder AR,Kruse AC,Earhart CA,Ohlendorf DH,Potter LR

更新日期：2008-09-01 00:00:00

abstract：:Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...

journal_title：Peptides

authors： Muraki K,Mitra SP,Dobner PR,Carraway RE

更新日期：1993-11-01 00:00:00

abstract：:Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...

journal_title：Peptides

authors： Kohjitani A,Shirakawa J,Okada S,Obara H

更新日期：1996-01-01 00:00:00

abstract：:Amylin and the structurally and functionally related peptide calcitonin gene-related peptide (CGRP) have been shown to reduce food intake in rats. The aim of the present study was to compare the anorectic potency of both peptides over a wide dose range when administered into the lateral brain ventricle (ICV). Furtherm...

journal_title：Peptides

authors： Lutz TA,Rossi R,Althaus J,Del Prete E,Scharrer E

更新日期：1998-01-01 00:00:00

abstract：:The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...

journal_title：Peptides

authors： Devemy E,Blaschuk OW

更新日期：2008-11-01 00:00:00

abstract：:The first member of the periviscerokinin peptide family in Locusta migratoria was identified by post-source decay fragmentation on a MALDI-TOF mass spectrometer using a single neurohemal organ only. The primary sequence of this decapeptide, code-named Lom-PVK, is Ala-Ala-Gly-Leu-Phe-Gln-Phe-Pro-Arg-Val-NH(2). Unlike t...

journal_title：Peptides

authors： Predel R,Gäde G

更新日期：2002-04-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Obestatin is produced in the stomach from proghrelin by post-translational cleavage. The initial report claimed anorexigenic effects of obestatin in mice. Contrasting studies indicated no effect of obestatin on food intake (FI). We investigated influences of metabolic state (fed/fasted), environmental factors (dark/li...

journal_title：Peptides

authors： Kobelt P,Wisser AS,Stengel A,Goebel M,Bannert N,Gourcerol G,Inhoff T,Noetzel S,Wiedenmann B,Klapp BF,Taché Y,Mönnikes H

更新日期：2008-06-01 00:00:00

abstract：:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...

journal_title：Peptides

authors： Alrubaian J,Lecaude S,Barba J,Szynskie L,Jacobs N,Bauer D,Brown C,Kaminer I,Bagrosky B,Dores RM

更新日期：2006-04-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr post...

journal_title：Peptides

authors： Kalra SP,Dube MG,Kalra PS

更新日期：1988-07-01 00:00:00

abstract：:Plant defensins are a prominent family of cationic peptides in the plant kingdom. They are structurally and functionally related to defensins that have been previously characterized in mammals and insects. They present molecular masses between 5 and 7kDa and possess a pattern of eight conserved Cys residues. The three...

journal_title：Peptides

authors： Carvalho Ade O,Gomes VM

更新日期：2009-05-01 00:00:00

abstract：:The peptide IIAEK derived from beta-lactoglobulin has a hypocholesterolemic activity greater than that of beta-sitosterol. To create food proteins with multiple copies of this valuable peptide sequence, we introduced tandem multimers of the nucleotide sequence encoding the peptide into DNA regions corresponding to the...

journal_title：Peptides

authors： Prak K,Maruyama Y,Maruyama N,Utsumi S

更新日期：2006-06-01 00:00:00

abstract：:So far numerous antimicrobial peptides have been characterized from amphibians. In this work, a new family of antimicrobial peptides, named shuchin, was purified and characterized from skin secretions of the frog, Rana shuchinae that lives in freezing mountains. Totally two members of shuchin (shuchin 1 and 2) were id...

journal_title：Peptides

authors： Zheng R,Yao B,Yu H,Wang H,Bian J,Feng F

更新日期：2010-09-01 00:00:00

abstract：:The interaction of two cathelicidin antimicrobial peptides, LL-37 and SMAP-29, with three bacterial polysaccharides, respectively, produced by Pseudomonas aeruginosa, Burkholderia cepacia and Klebsiella pneumoniae, was investigated to identify possible mechanisms adopted by lung pathogens to escape the action of innat...

journal_title：Peptides

authors： Herasimenka Y,Benincasa M,Mattiuzzo M,Cescutti P,Gennaro R,Rizzo R

更新日期：2005-07-01 00:00:00

abstract：:The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...

journal_title：Peptides

authors： Vendite D,Rocha JB,Souza DO

更新日期：1988-07-01 00:00:00

abstract：:The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass spectrometry in samples containing the brain, the subesophageal ganglion, the corpora cardiaca-corpus a...

journal_title：Peptides

authors： Settembrini BP,de Pasquale D,Postal M,Pinto PM,Carlini CR,Villar MJ

更新日期：2011-03-01 00:00:00

abstract：:beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...

journal_title：Peptides

authors： Yamauchi R,Wada E,Yamada D,Yoshikawa M,Wada K

更新日期：2006-12-01 00:00:00