Abstract:
:Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentrations of EGTA (a Ca++ chelator), indicating that a Ca++ pathway may play a key role in the BBS-stimulated CL response.
journal_name
Peptidesjournal_title
Peptidesauthors
Jin GF,Guo YS,Smith ER,Houston CWdoi
10.1016/0196-9781(90)90098-psubject
Has Abstractpub_date
1990-03-01 00:00:00pages
393-6issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(90)90098-Pjournal_volume
11pub_type
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