Regulation of hepcidin in HepG2 and RINm5F cells.

abstract：:The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...

journal_title：Peptides

authors： Bhargava HN,Gulati A

更新日期：1988-07-01 00:00:00

abstract：:Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...

journal_title：Peptides

authors： Hikosaka T,Tsuruda T,Nagata S,Kuwasako K,Tsuchiya K,Hoshiko S,Inatsu H,Chijiiwa K,Kitamura K

更新日期：2011-09-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

journal_title：Peptides

authors： Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

更新日期：2018-09-01 00:00:00

abstract：:To confirm and extend the results of previous studies which demonstrated central cardiovascular effects of vasopressin in anesthetized rats, we determined blood pressure and heart rate changes for 30 minutes after intracerebroventricular injections of arginine vasopressin, arginine vasotocin and oxytocin in conscious ...

journal_title：Peptides

authors： Zerbe RL,Kirtland S,Faden AI,Feuerstein G

更新日期：1983-09-01 00:00:00

abstract：:Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...

journal_title：Peptides

authors： Brauns O,Brauns S,Jenke M,Zimmermann B,Dautzenberg FM

更新日期：2002-10-01 00:00:00

abstract：:The effect of vasoactive intestinal peptide (VIP) on the nerve-stimulated contraction, tissue oxygenation, lipid peroxidation and antioxidant enzymes activities-superoxide dismutase and catalase was investigated in the rat gastrocnemius muscle exposed to 4 h ischemia-4hr reperfusion. Ischemia caused significant decrea...

journal_title：Peptides

authors： Tunçel N,Erden S,Uzuner K,Altiokka G,Tunçel M

更新日期：1997-01-01 00:00:00

abstract：:The involvement of spinal opioid receptors and spinal monoaminergic systems, in the antinociceptive effect of intrathecal (IT) salmon calcitonin, has been evaluated by means of the hot plate test, in the rat. Intrathecal pretreatment with 40 micrograms MR 1452 and 40 micrograms ICI 154,129, purported selective antagon...

journal_title：Peptides

authors： Candeletti S,Romualdi P,Spadaro C,Spampinato S,Ferri S

更新日期：1985-01-01 00:00:00

abstract：:Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...

journal_title：Peptides

authors： Hoare SR,Sullivan SK,Pahuja A,Ling N,Crowe PD,Grigoriadis DE

更新日期：2003-12-01 00:00:00

abstract：:The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...

journal_title：Peptides

authors： Correa FM,Viswanathan M,Ciuffo GM,Tsutsumi K,Saavedra JM

更新日期：1995-01-01 00:00:00

abstract：:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise G

更新日期：1999-11-01 00:00:00

abstract：:Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inh...

journal_title：Peptides

authors： Lee EW,Grant DS,Movafagh S,Zukowska Z

更新日期：2003-01-01 00:00:00

abstract：:The aspartic protease inhibitor (ATBI) purified from a Bacillus sp. is a potent inhibitor of several proteases including recombinant HIV-1 protease, pepsin, and fungal aspartic protease. In this study, we report the cloning, and over expression of a synthetic gene coding for ATBI in Escherichia coli and establish a pu...

journal_title：Peptides

authors： Vathipadiekal V,Umasankar PK,Patole MS,Rao M

更新日期：2010-01-01 00:00:00

abstract：:Crustacean hyperglycemic hormone (CHH) not only plays an important role in the modulation of hemolymph glucose level but also functions in other biological events including molting, reproduction and stress response. Of the six CHHs characterized in Marsupenaeus japonicus, an expression system for recombinant Pej-SGP-V...

journal_title：Peptides

authors： Nagai C,Asazuma H,Nagata S,Ohira T,Nagasawa H

更新日期：2009-03-01 00:00:00

abstract：:Apelin was recently found to be an inotropic polypeptide in isolated rat hearts, and intravenous injection of apelin can induce a transient decrease in blood pressure. To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) path...

journal_title：Peptides

authors： Jia YX,Lu ZF,Zhang J,Pan CS,Yang JH,Zhao J,Yu F,Duan XH,Tang CS,Qi YF

更新日期：2007-10-01 00:00:00

abstract：:We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...

journal_title：Peptides

authors： Fujimoto M,Sakamoto T,Kanetoh T,Osaka M,Moriyama S

更新日期：2006-05-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...

journal_title：Peptides

authors： Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GG

更新日期：1997-01-01 00:00:00

abstract：:Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...

journal_title：Peptides

authors： Widerlöv E,Mueller RA,Frye GD,Breese GR

更新日期：1984-05-01 00:00:00

abstract：:The proteolytic conversion of oxytocin and vasopressin by purified rat brain synaptic membranes was studied at 37 degrees C and physiological pH 7.4. The formed peptide fragments were isolated by high performance liquid chromatography and characterized by amino acid analysis. When oxytocin was incubated with synaptic ...

journal_title：Peptides

authors： Stancampiano R,Melis MR,Argiolas A

更新日期：1991-09-01 00:00:00

abstract：:Ghrelin is broadly expressed in myocardial tissues, where it exerts different functions. It also has been found to have a wide variety of biological functions on cell differentiation and tissue development. The aim of this study was to investigate the effect of ghrelin on human embryonic stem cell (hESC) differentiati...

journal_title：Peptides

authors： Gao M,Yang J,Liu G,Wei R,Zhang L,Wang H,Wang G,Gao H,Chen G,Hong T

更新日期：2012-04-01 00:00:00

abstract：:Neuropeptide Y (NPY) receptor binding sites have been characterized in rat brain using both membrane preparations and receptor autoradiography. Radiolabelled NPY binds with high affinity and specificity to an apparent single class of sites in rat brain membrane preparations. The ligand selectivity pattern reveals stro...

journal_title：Peptides

authors： Martel JC,St-Pierre S,Quirion R

更新日期：1986-01-01 00:00:00

abstract：:Dihydroergotoxine (DHET) is comprised of equal part of the mesylates of dihydroergocristine, dihydroergocornine and dihydroergocryptine. In the standard radioreceptor assays, DHET components displaced the CNS-receptor binding of [3H]-enkephalin (ENK) and [3H]thyrotropin releasing hormone (TRH). The inhibitory effect o...

journal_title：Peptides

authors： Ogawa N,Mizuno S,Mori A,Kuroda H

更新日期：1984-01-01 00:00:00

abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...

journal_title：Peptides

authors： Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

更新日期：2004-04-01 00:00:00

abstract：:We demonstrated the production and release of a peptide structurally identical with porcine and bovine VIP-28 in human neuroblastoma NB-OK-1 cell line. In the cells, VIP-like immunoreactive (IR-VIP) components of 8 K dalton (Kd), 11 Kd, 18 Kd and 30 Kd were also detected and the 8 Kd and 18 Kd components were apparent...

journal_title：Peptides

authors： Hoshino M,Yanaihara C,Ogino K,Iguchi K,Sato H,Suzuki T,Yanaihara N

更新日期：1984-03-01 00:00:00

abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...

journal_title：Peptides

authors： da Silva BR,de Freitas VA,Nascimento-Neto LG,Carneiro VA,Arruda FV,de Aguiar AS,Cavada BS,Teixeira EH

更新日期：2012-08-01 00:00:00

abstract：:New dual immunocytochemical staining procedures were used in the same tissue section to elucidate the distribution and co-existence of CRF and vasopressin in parvocellular neuronal perikarya in the paraventricular nucleus (PVN) of rat hypothalamus. CRF immunostained cells were for the most part concentrated in the med...

journal_title：Peptides

authors： Piekut DT,Joseph SA

更新日期：1986-09-01 00:00:00

abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

journal_title：Peptides

authors： Fehmann HC,Göke B

更新日期：1995-01-01 00:00:00

abstract：:Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-termina...

journal_title：Peptides

authors： Grzesiak JJ,Burton DW,Deftos LJ,Bouvet M

更新日期：2006-07-01 00:00:00

abstract：:The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...

journal_title：Peptides

authors： Liao M,Lu Y,Xiao Y,Dierich MP,Chen Y

更新日期：2000-04-01 00:00:00