Abstract:
:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloning of prodynorphin-related genes from the pufferfish and zebrafish supports the latter hypothesis. This study analyzes trends in the radiation of the prodynorphin gene in teleosts. Prodynorphin cDNAs were cloned from the brain of the eel Anguilla rostrata and the Nile tilapia, Oreochromis niloticus. These teleost prodynorphin sequences have distinct alpha-neoendorphin, dynorphin A, and dynorphin B sequences, and a novel opioid sequence, YGGFI. The relationship of these teleost prodynorphin sequences to other actinopterygian and sarcopterygian prodynorphin sequences will be discussed.
journal_name
Peptidesjournal_title
Peptidesauthors
Alrubaian J,Lecaude S,Barba J,Szynskie L,Jacobs N,Bauer D,Brown C,Kaminer I,Bagrosky B,Dores RMdoi
10.1016/j.peptides.2005.09.007subject
Has Abstractpub_date
2006-04-01 00:00:00pages
797-804issue
4eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00433-Xjournal_volume
27pub_type
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