Decreased dynorphin levels and increased kappa opioid receptor binding in male rats with isolation-induced hypertension.

Abstract:

:The role of hippocampal dynorphin A (1-8) (Dyn A (1-8)) and kappa opioid receptors was investigated in the isolation-induced hypertensive rat (IHR). Male Sprague Dawley rats were either isolated (1 per cage) or grouped (3 per cage) for 7 days. Isolated rats exhibited increased blood pressure (systolic blood pressure 159.7 +/- 6.6 mmHg) whereas the grouped rats remained normotensive (systolic blood pressure 137 +/- 6.3 mmHg). Using radioligand binding techniques we observed a significant increase in kappa opioid receptor binding in the hippocampus of isolated rats (56% increase) and this further increased when the length of isolation was increased to 2 weeks (72% increase). Radioimmunoassay showed that isolation decreased the hippocampal content of Dyn A (1-8) from 12.7 +/- 0.4 to 11.6 +/- 0.2 pg Dyn A (1-8) per 10 mg tissue (rats weighing approximately 100 g) and from 13.3 +/- 0.8 to 9.7 +/- 1 pg Dyn A (1-8) per 10 mg tissue (approximately 200 g rats). These data suggest that functional alterations in the hippocampal dynorphin system may be involved in the maintenance of isolation induced hypertension.

journal_name

Peptides

journal_title

Peptides

authors

Wright RC,McConnaughey MM,Ingenito AJ

doi

10.1016/s0196-9781(00)00331-4

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1881-4

issue

12

eissn

0196-9781

issn

1873-5169

pii

S0196978100003314

journal_volume

21

pub_type

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