Abstract:
:Quantitative receptor autoradiography was used to examine the binding of [125I]-human CGRP in the dorsal horn of the L4 spinal segment of rats with a chronic constriction injury (CCI) of the sciatic nerve or unilateral dorsal rhizotomies of spinal segments L1-L6. At the times selected for study, we found no change in the amount of CGRP binding in any areas examined following CCI. In contrast, our results showed a temporally related increase in the amount of CGRP binding in areas within laminae I-II and in lateral lamina V of the dorsal horn ipsilateral to the rhizotomies. These results indicate that CGRP binding sites are regulated, most likely, by changes in the release of CGRP. Further, our results suggest that the release of CGRP from primary afferent neurons is unchanged in animals with a CCI.
journal_name
Peptidesjournal_title
Peptidesauthors
Garry MG,Kajander KC,Bennett GJ,Seybold VSdoi
10.1016/0196-9781(91)90221-asubject
Has Abstractpub_date
1991-11-01 00:00:00pages
1365-73issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(91)90221-Ajournal_volume
12pub_type
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