Abstract:
:Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the presence of NPR-C in the rat retina and its relationship to cholinergic and dopaminergic amacrine cells using immunofluorescence techniques. NPR-C immunoreactivity was found in several layers of the retina including the ganglion cell layer (GCL), inner nuclear layer (INL), outer plexiform layer (OPL), and inner segments of photoreceptors (IS). Immunofluorescence double-labeling showed the co-localization of NPR-C with tyrosine hydroxylase, a marker of dopaminergic cells, and with choline acetyltransferase (ChAT), a marker of cholinergic cells. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C.
journal_name
Peptidesjournal_title
Peptidesauthors
Abdelalim EM,Tooyama Idoi
10.1016/j.peptides.2009.10.014subject
Has Abstractpub_date
2010-01-01 00:00:00pages
180-3issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(09)00465-3journal_volume
31pub_type
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