NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina.

Abstract:

:Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the presence of NPR-C in the rat retina and its relationship to cholinergic and dopaminergic amacrine cells using immunofluorescence techniques. NPR-C immunoreactivity was found in several layers of the retina including the ganglion cell layer (GCL), inner nuclear layer (INL), outer plexiform layer (OPL), and inner segments of photoreceptors (IS). Immunofluorescence double-labeling showed the co-localization of NPR-C with tyrosine hydroxylase, a marker of dopaminergic cells, and with choline acetyltransferase (ChAT), a marker of cholinergic cells. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C.

journal_name

Peptides

journal_title

Peptides

authors

Abdelalim EM,Tooyama I

doi

10.1016/j.peptides.2009.10.014

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

180-3

issue

1

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(09)00465-3

journal_volume

31

pub_type

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