Abstract:
:ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic receptors. A mechanism involving an interaction of ACTH-(1-24) with the phospholipid core of the receptors is suggested. Structure activity studies point to a relation with reported effects of intracerebroventricularly administered ACTH on the turnover rate of acetylcholine and the ACTH-induced stretching and yawning syndrome.
journal_name
Peptidesjournal_title
Peptidesauthors
Tonnaer JA,Van Vugt M,De Graaf JSdoi
10.1016/0196-9781(86)90009-4subject
Has Abstractpub_date
1986-05-01 00:00:00pages
425-9issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(86)90009-4journal_volume
7pub_type
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