Abstract:
:In 1989, the development of specific angiotensin receptor antagonists which distinguish between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in angiotensin research. It turned out, that the AT1 receptor was almost entirely responsible for the "classical" actions of angiotensin II related to the regulation of blood pressure as well as volume and electrolyte balance. However, actions and signal transduction mechanisms coupled to the AT2 receptor remained enigmatic for a long time. The present review summarizes the current knowledge of AT2 receptor distribution, signaling and function with an emphasis on growth/anti-growth, differentiation and the regeneration of neuronal tissue.
journal_name
Peptidesjournal_title
Peptidesauthors
Steckelings UM,Kaschina E,Unger Tdoi
10.1016/j.peptides.2005.03.010subject
Has Abstractpub_date
2005-08-01 00:00:00pages
1401-9issue
8eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00125-7journal_volume
26pub_type
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