Four cross-linked HIV Gag peptides prime the immune response to HIV proteins in mice.

abstract：:The puromycin-sensitive aminopeptidase (ApPS) is a zinc metallopeptidase involved in the degradation of neuropeptides. Putative catalytic residues of the enzyme, Cys146, Glu338, and Lys396 were mutated, and the resultant mutant enzymes characterized. ApPS C146S exhibited normal catalytic activity, ApPS E338A exhibited...

journal_title：Peptides

authors： Thompson MW,Hersh LB

更新日期：2003-09-01 00:00:00

abstract：:The effect of proadrenomedullin N-terminal 20 peptide (PAMP) on the proliferative activity of rat zona glomerulosa (ZG) cells has been investigated. Dispersed rat ZG cells were cultured in vitro for 24 h and then exposed to PAMP for an additional 24 h, and the proliferation rate was assessed by the 5-bromo-2'-deoxyuri...

journal_title：Peptides

authors： Rebuffat P,Gottardo L,Malendowicz LK,Neri G,Nussdorfer GG

更新日期：2001-11-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) overexpression, induced by the intracerebroventricular (i.c.v.) injection of an recombinant adeno-associated viral vector encoding LIF (rAAV-LIF), resulted in a dose-dependent reduction in body weight (BW) gain, food intake (FI) and adiposity, evidenced by suppression of serum leptin a...

journal_title：Peptides

authors： Beretta E,Dhillon H,Kalra PS,Kalra SP

更新日期：2002-05-01 00:00:00

abstract：:One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...

journal_title：Peptides

authors： Guo CT,McClean S,Shaw C,Rao PF,Ye MY,Bjourson AJ

更新日期：2013-05-01 00:00:00

abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

journal_title：Peptides

authors： Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

更新日期：1995-01-01 00:00:00

abstract：:Many mammalian brain-gut peptides are known to be represented in invertebrate nervous systems; we have now examined the possibility that an invertebrate neuropeptide occurs in vertebrates. Antisera were raised in rabbits to the molluscan neuropeptide. Phe-Met-Arg-Phe-NH2 (FMRFamide). The antiserum used for radioimmuno...

journal_title：Peptides

authors： Dockray GJ,Vaillant C,Williams RG,Gayton RJ,Osborne NN

更新日期：1981-01-01 00:00:00

abstract：:Ceratotoxin A (CtxA), a 36-residue alpha-helical cationic peptide isolated from the medfly Ceratitis capitata, exhibits strong antibacterial activity. To determine its mode of action against bacteria, we investigated the behavior of ceratotoxin A by incorporating it into planar lipid bilayers. Macroscopic and single c...

journal_title：Peptides

authors： Saint N,Marri L,Marchini D,Molle G

更新日期：2003-11-01 00:00:00

abstract：:Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...

journal_title：Peptides

authors： Chakrabarti AK,Chatterjee TK,Ghosh JJ

更新日期：1983-05-01 00:00:00

abstract：:In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...

journal_title：Peptides

authors： Nakajima T,Yasuhara T,Uzu S,Wakamatsu K,Miyazawa T,Fukuda K,Tsukamoto Y

更新日期：1985-01-01 00:00:00

abstract：:Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...

journal_title：Peptides

authors： Williams DL,Coiduras II,Parise EM,Maske CB

更新日期：2020-11-01 00:00:00

abstract：:We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P<0.01) in blood pressure, heart rate, endo...

journal_title：Peptides

authors： Fontana F,Bernardi P,Lanfranchi G,Conti E,Spampinato S,Di Toro R,Bonafè F,Coccheri S

更新日期：2005-12-01 00:00:00

abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...

journal_title：Peptides

authors： Chang CL,Roh J,Hsu SY

更新日期：2004-10-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:The antibacterial activity of peptides without disulfide bridges, spanning the carboxy-terminal segment of arthropod defensins, has been investigated. Although all the peptides have net positive charges, they exhibited varying antibacterial potencies and spectra. Atomic force and fluorescence microscopic analyses indi...

journal_title：Peptides

authors： Varkey J,Singh S,Nagaraj R

更新日期：2006-11-01 00:00:00

abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...

journal_title：Peptides

authors： Asakawa A,Inui A,Ueno N,Fujimiya M,Fujino MA,Kasuga M

更新日期：1999-12-01 00:00:00

abstract：:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...

journal_title：Peptides

authors： Samson WK,Taylor MM

更新日期：2006-05-01 00:00:00

abstract：:Motilin is a regulatory polypeptide of 22 amino acid residues and orginates in motilin cells scattered in the duodenal epithelium of most mammals and chickens. Motilin is released into the general circulation at about 100-min intervals during the interdigestive state and is the most important factor in controlling the...

journal_title：Peptides

authors： Itoh Z

更新日期：1997-01-01 00:00:00

abstract：:We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...

journal_title：Peptides

authors： Szeto HH,Soong Y,Wu D,Olariu N,Kett A,Kim H,Clapp JF

更新日期：1999-01-01 00:00:00

abstract：:BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...

journal_title：Peptides

authors： Yang S,Lee CW,Kim HJ,Jung HH,Kim JI,Shin SY,Shin SH

更新日期：2019-08-01 00:00:00

abstract：:In the cephalopod mollusk Octopus vulgaris, the gonadotropic hormone released by the optic gland controls sexual maturity. Several lobes of the central nervous system control the activity of this gland. In one of these lobes, the olfactory lobe, a gonadotropin releasing hormone (GnRH) neuronal system has been describe...

journal_title：Peptides

authors： Di Cristo C,De Lisa E,Di Cosmo A

更新日期：2009-03-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and endothelin (ET) are endogenous vasoactive factors that exert potent diuretic and natriuretic actions. We have previously shown that ANP and ET-3 act through an NO pathway to inhibit the sodium-glucose cotransporter (SGLT) in the intestine [Gonzalez Bosc LV, Elustondo PA, Ortiz MC, ...

journal_title：Peptides

authors： Majowicz MP,Gonzalez Bosc LV,Albertoni Borghese MF,Delgado MF,Ortiz MC,Sterin Speziale N,Vidal NA

更新日期：2003-12-01 00:00:00

abstract：:The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential ant...

journal_title：Peptides

authors： Brouwer CP,Bogaards SJ,Wulferink M,Velders MP,Welling MM

更新日期：2006-11-01 00:00:00

abstract：:There are two distinct mRNAs that encode the precursor to gastrin-releasing peptide (GRP) in rat brain. These two messages arise from separate transcription initiation sites located approximately 400 base pairs apart, which are presumably regulated by separate promoters. In the present study, we mapped the distributio...

journal_title：Peptides

authors： Zoeller RT,Lebacq-Verheyden AM,Battey JF

更新日期：1989-03-01 00:00:00

abstract：:The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...

journal_title：Peptides

authors： Yulis CR,Lederis K,Wong KL,Fisher AW

更新日期：1986-01-01 00:00:00

abstract：:We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...

journal_title：Peptides

authors： Zhao Y,Wang MY,Hao K,Chen XQ,Du JZ

更新日期：2013-06-01 00:00:00

abstract：:This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin...

journal_title：Peptides

authors： Puentes A,García J,Ocampo M,Rodríguez L,Vera R,Curtidor H,López R,Suarez J,Valbuena J,Vanegas M,Guzman F,Tovar D,Patarroyo ME

更新日期：2003-07-01 00:00:00

abstract：:There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...

journal_title：Peptides

authors： Tagai C,Morita S,Shiraishi T,Miyaji K,Iwamuro S

更新日期：2011-10-01 00:00:00

abstract：:Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...

journal_title：Peptides

authors： Li KW,Geraerts WP,Joosse J

更新日期：1992-03-01 00:00:00

abstract：:The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...

journal_title：Peptides

authors： Vendite D,Rocha JB,Souza DO

更新日期：1988-07-01 00:00:00

abstract：:[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...

journal_title：Peptides

authors： D'Souza MM,Carr JA

更新日期：1998-01-01 00:00:00