Abstract：
:In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells to release histamine from the cells, and act on the adrenal chromaffin cells to release catecholamines and adenylic acids. Some mastoparans cause hemolysis and serotonin release from the platelets. The new cytotrophic peptides as the second major components are tridecapeptide amides possessing chemotactic activity for polymorphonuclear leucocytes and monocytes. Some of the peptides in this family also cause histamine release from the mast cells. Mastoparan takes a random coil structure in aqueous solution but changes its conformation to alpha-helix in methanolic solution or in the presence of lysophosphatidyl choline. This fact is confirmed also by the transferred nuclear overhauser effect by NMR analysis. The similar phenomenon was observed in the family of chemotactic peptides. The helical conformation of these peptides are amphipathic structure in which all of side chains of the hydrophobic amino acids are located on one side of the axis, and those of the basic or the hydrophilic amino acid residues are on an opposite side. Mastoparan enhances the membrane conductivity of the lipid bilayer when the peptide is investigated by the black lipid membrane experiment. This indicates that the peptide may be assembled in the membrane by changing its conformation and, for some reason, enhances the ion transfer through the membrane. These properties of the peptide may reveal various activities on the cell membrane.
journal_name
Peptidesjournal_title
Peptidesauthors
Nakajima T,Yasuhara T,Uzu S,Wakamatsu K,Miyazawa T,Fukuda K,Tsukamoto Ydoi
10.1016/0196-9781(85)90409-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
425-30eissn
0196-9781issn
1873-5169pii
0196-9781(85)90409-7journal_volume
6 Suppl 3pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90071-9
更新日期：1986-01-01 00:00:00
abstract：:The distribution of the VIP containing structures was studied in the gut and in the paravertebral sympathetic ganglia of the quail and chick embryos by immunocytochemistry. In the gut, development of peptidergic nerves followed a craniocaudal gradient. Immunoreactive fibres were first visible in the oesophagus at day ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90206-7
更新日期：1984-03-01 00:00:00
abstract：:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90153-8
更新日期：1994-01-01 00:00:00
abstract：:Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(99)00093-5
更新日期：1999-01-01 00:00:00
abstract：:Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.12.003
更新日期：2011-04-01 00:00:00
abstract：:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90152-f
更新日期：1991-07-01 00:00:00
abstract：:Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90144-0
更新日期：1986-11-01 00:00:00
abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00221-7
更新日期：2000-06-01 00:00:00
abstract：:The beta-casein-derived octapeptide RINKKIEK is a noncompetitive inhibitor of soybean lipoxygenase (LOX). To investigate the molecular determinants for the enzyme-peptide interaction, a peptide library containing substitutional analogs of RINKKIEK was prepared by SPOT synthesis and analyzed for interaction with fluore...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.09.018
更新日期：2007-12-01 00:00:00
abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.04.021
更新日期：2005-11-01 00:00:00
abstract：:The vasoactive peptide urotensin-II (U-II) is best known for its ability to regulate peripheral vascular and cardiac contractile function in vivo, and recent in vitro studies have suggested a role for the peptide in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated coll...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.05.028
更新日期：2005-12-01 00:00:00
abstract：:Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary aim of this study was to identify the TIMP-2 region involved in binding to the previously identified receptor integrin α3β1, and to determine whe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.08.010
更新日期：2011-09-01 00:00:00
abstract：:To investigate the contribution of the N-terminal sequence of h-EGF to its biological activity and the formation of three intramolecular disulfide bonds by oxidative refolding via air oxidation, five derivatives of h-EGF with a single N-terminal amino acid deletion were synthesized by solid-phase synthesis. The homoge...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00181-2
更新日期：1995-01-01 00:00:00
abstract：:The expression of the relaxin-3 gene, detected as a new member of the insulin superfamily using human genomic databases, is abundantly present in the brain and testis. Intracerebroventricularly (icv) administered relaxin-3 stimulates food intake. Icv administered relaxin (identical to relaxin-2 in humans) affects the ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.02.020
更新日期：2010-06-01 00:00:00
abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(81)90004-8
更新日期：1981-01-01 00:00:00
abstract：:The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.11.007
更新日期：2011-02-01 00:00:00
abstract：:We studied the expression of the osteogenic and antinociceptive C-terminal histone H4-related peptide fragments, H4-(89-102) (OGP) and H4-(86-100), respectively, within various rat tissues and isolated alveolar macrophages (AM) by radioimmunoassay (RIA). OGP was located mainly within the bone marrow, spleen, thymus, a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.03.013
更新日期：2005-08-01 00:00:00
abstract：:The aim of the present study was to investigate how suckling influences the plasma levels of oxytocin and vasoactive intestinal peptide in lactating dogs. Blood-samples were drawn from ten lactating beagles during suckling, in week one and week three of the five week long lactation period and the levels of vasoactive ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90002-7
更新日期：1987-05-01 00:00:00
abstract：:Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interac...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2007.04.023
更新日期：2007-06-01 00:00:00
abstract：:Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inh...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00281-4
更新日期：2003-01-01 00:00:00
abstract：:We have previously shown that brief, vena caval infusion of gastrin-releasing peptide1-27 (GRP), delivered shortly (5 min) after the end of the first spontaneous nocturnal meal, significantly prolongs the postprandial intermeal interval (IMI) without affecting the size of the subsequent meal in freely-feeding rats. In...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00097-7
更新日期：1998-01-01 00:00:00
abstract：:The analysis of the spectrum of circular dichroism (CD) of methionine-oxidized bovine parathyroid hormone peptide, bPTH(1-34) revealed that approximately 43% of the orderly conformation (alpha-helix and beta-sheet) was converted into random coil structure. This peptide failed to elicit any hypotensive response in rats...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90143-9
更新日期：1986-11-01 00:00:00
abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.014
更新日期：2013-10-01 00:00:00
abstract：:The localization of CCK8-, bombesin- and VIP-like immunoreactivities in the myenteric plexus of the guinea pig small intestine has been studied by radioimmunoassay of extracts of longitudinal muscle strips obtained with and without adherent myenteric plexus; concentrations were compared with those in other regions of ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80007-1
更新日期：1981-04-01 00:00:00
abstract：:The antinociceptive effect of i.t.-administered Tyr-d-Arg-Phe-β-Ala (TAPA), an N-terminal tetrapeptide analog of dermorphin, was characterized in ddY mice. In the mouse tail-flick test, TAPA administered i.t. produced a potent antinociception. The antinociception induced by TAPA was significantly attenuated by i.t. pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90061-0
更新日期：1985-03-01 00:00:00
abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.032
更新日期：2013-03-01 00:00:00
abstract：:Each of the dynorphin A(1-13) or dynorphin (dyn) treatment groups receiving naloxone showed a significant overall reduction of overt signs compared with the dyn controls. The data suggested that the overt psychomotor effects of dyn in the rhesus monkey were especially prone to blockade by naloxone, and probably involv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90196-a
更新日期：1992-07-01 00:00:00
abstract：:Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.06.016
更新日期：2014-09-01 00:00:00
