Abstract:
:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued for 4 h. The intraperitoneal (i.p.) injection of mPP (0.03-30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after i.p. injection and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of mPP (0.003-3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice.
journal_name
Peptidesjournal_title
Peptidesauthors
Asakawa A,Inui A,Ueno N,Fujimiya M,Fujino MA,Kasuga Mdoi
10.1016/s0196-9781(99)00155-2subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1445-8issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(99)00155-2journal_volume
20pub_type
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