Cholecystokinin octapeptide purified from brains of Australian marsupials.

abstract：:Intrathecal injection of mice with substance P (SP) or its C-terminal fragments results in a behavioral syndrome characterized by reciprocal caudally directed biting and scratching. Repeated injection of SP, but not SP C-terminal fragments, results in a decrease in the intensity of, or desensitization to, these SP-ind...

journal_title：Peptides

authors： Igwe OJ,Sun X,Larson AA

更新日期：1990-07-01 00:00:00

abstract：:The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...

journal_title：Peptides

authors： Denbow DM,Myers RD

更新日期：1982-09-01 00:00:00

abstract：:The conformational properties of the competitive angiotensin II antagonist sarmesin [Sar-Arg-Val-Tyr(Me)-His-Pro-Phe] and its heptapeptide analogue [des1]sarmesin in dimethylsulphoxide-d6 were investigated by nuclear Overhauser effect (NOE) enhancement studies. Assignment of all backbone and side-chain protons was pos...

journal_title：Peptides

authors： Matsoukas JM,Yamdagni R,Moore GJ

更新日期：1990-03-01 00:00:00

abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...

journal_title：Peptides

authors： da Silva BR,de Freitas VA,Nascimento-Neto LG,Carneiro VA,Arruda FV,de Aguiar AS,Cavada BS,Teixeira EH

更新日期：2012-08-01 00:00:00

abstract：:Evidence on the relative roles of endothelin ET(A) and ET(B) receptors in mediating the nociceptive and hyperalgesic actions of endothelin-1 is still fragmented and conflicting, due to variations between species and/or models. This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavi...

journal_title：Peptides

authors： Motta EM,Chichorro JG,D'Orléans-Juste P,Rae GA

更新日期：2009-05-01 00:00:00

abstract：:The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...

journal_title：Peptides

authors： Geraghty RF,Irvine GB,Williams CH,Cottrell GA

更新日期：1994-01-01 00:00:00

abstract：:Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...

journal_title：Peptides

authors： Ohara K,Kohno M,Hamada T,Kawakami K

更新日期：2013-12-01 00:00:00

abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...

journal_title：Peptides

authors： Park CW,Kim JH,Kim KM,Hwang JS,Kang SW,Kang HS,Cho BP,Yu CH,Kim HR,Lee BH

更新日期：2004-11-01 00:00:00

abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...

journal_title：Peptides

authors： Takamatsu K,Tatemoto K

更新日期：1991-03-01 00:00:00

abstract：:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...

journal_title：Peptides

authors： Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog H

更新日期：2007-02-01 00:00:00

abstract：:Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...

journal_title：Peptides

authors： King PJ,Widdowson PS,Doods H,Williams G

更新日期：2000-01-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:The puromycin-sensitive aminopeptidase (ApPS) is a zinc metallopeptidase involved in the degradation of neuropeptides. Putative catalytic residues of the enzyme, Cys146, Glu338, and Lys396 were mutated, and the resultant mutant enzymes characterized. ApPS C146S exhibited normal catalytic activity, ApPS E338A exhibited...

journal_title：Peptides

authors： Thompson MW,Hersh LB

更新日期：2003-09-01 00:00:00

abstract：:One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...

journal_title：Peptides

authors： Guo CT,McClean S,Shaw C,Rao PF,Ye MY,Bjourson AJ

更新日期：2013-05-01 00:00:00

abstract：:The Y5 receptor has been postulated to be the main receptor mediating NPY-induced food intake in rats, based on its pharmacological profile and mRNA distribution. To further characterize this important receptor subtype, we isolated the Y5 gene in the guinea pig, a widely used laboratory animal in which all other known...

journal_title：Peptides

authors： Lundell I,Eriksson H,Marklund U,Larhammar D

更新日期：2001-03-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:Discovering the informational rule(s) underlying structure-function relationships in the protein language is at the core of biology. Current theories have proven inadequate to explain the origins of biological information such as that found in nucleotide and amino acid sequences. Here, we demonstrate that the informat...

journal_title：Peptides

authors： Kanduc D

更新日期：2010-05-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:The leucosulfakinins (LSKs), isolated from head extracts of the cockroach Leucophaea maderae, are sulfated neuropeptides with homology to gastrin and cholecystokinin. The undecapeptide LSK and decapeptide LSK-II stimulate contractions of the isolated cockroach hindgut. Several structural aspects of the two gastrin/CCK...

journal_title：Peptides

authors： Nachman RJ,Holman GM,Haddon WF

更新日期：1988-01-01 00:00:00

abstract：:Neuropeptide S (NPS) produces several biological actions by activating a formerly orphan GPCR, now named NPS receptor (NPSR). It has been previously demonstrated that NPS stimulates murine leukocyte chemotaxis in vitro. In the present study we investigated the ability of NPS, in comparison with the proinflammatory pep...

journal_title：Peptides

authors： Filaferro M,Novi C,Ruggieri V,Genedani S,Alboni S,Malagoli D,Caló G,Guerrini R,Vitale G

更新日期：2013-01-01 00:00:00

abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...

journal_title：Peptides

authors： Fried S,O'Neill K,Hawes BE

更新日期：2002-08-01 00:00:00

abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

journal_title：Peptides

authors： Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

更新日期：2018-09-01 00:00:00

abstract：:Structurally unique, synthetic prion peptides provide the basis of a simple assay to serve as both a detection and signal amplification system that distinguishes the normal prion protein, PrPC, from the misfolded prion protein, PrPSc, that is associated with the occurrence of transmissible spongiform encephalopathies ...

journal_title：Peptides

authors： Grosset A,Moskowitz K,Nelsen C,Pan T,Davidson E,Orser CS

更新日期：2005-11-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...

journal_title：Peptides

authors： Téné N,Bonnafé E,Berger F,Rifflet A,Guilhaudis L,Ségalas-Milazzo I,Pipy B,Coste A,Leprince J,Treilhou M

更新日期：2016-05-01 00:00:00

abstract：:Urotensin II (UII), which was originally isolated from the teleost urophysis, was identified as an endogenous ligand for orphan G protein-coupled receptor 14 (GPR14). The structure of mammalian UII was confirmed by isolation from spinal cord in porcine, or was easily predicted from the sequence of prepro-UII in human....

journal_title：Peptides

authors： Sugo T,Mori M

更新日期：2008-05-01 00:00:00

abstract：:The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...

journal_title：Peptides

authors： Tanaka M,Tomimatsu Y,Sakimura K,Ootani Y,Sako Y,Kojima T,Aso K,Yano T,Hirai K

更新日期：2017-09-01 00:00:00

abstract：:Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interacti...

journal_title：Peptides

authors： Wan Y,Xue R,Wang Y,Zhang Q,Huang S,Wu W,Ye H,Zhang Z,Li Y

更新日期：2015-01-01 00:00:00

abstract：:Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...

journal_title：Peptides

authors： Boccia L,Gamakharia S,Coester B,Whiting L,Lutz TA,Le Foll C

更新日期：2020-10-01 00:00:00

abstract：:Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) an...

journal_title：Peptides

authors： Carvalho MC,Masson S,Brandão ML,de Souza Silva MA

更新日期：2008-07-01 00:00:00