Abstract:
:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spontaneously from recurrent mossy fiber terminals, reduces glutamate release from those terminals by activating presynaptic Y2 receptors, and depresses granule cell epileptiform activity dependent on the recurrent pathway. These effects are much greater in rats than in C57BL/6 mice, despite apparently equivalent mossy fiber sprouting and neoexpression of NPY. This species difference can be explained by contrasting changes in the expression of mossy fiber Y2 receptors; seizures upregulate Y2 receptors in rats but downregulate them in mice. The recurrent mossy fiber pathway may synchronize granule cell discharge more effectively in humans and mice than in rats, due to its lower expression of either NPY (humans) or Y2 receptors (mice).
journal_name
Peptidesjournal_title
Peptidesauthors
Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog Hdoi
10.1016/j.peptides.2006.07.026subject
Has Abstractpub_date
2007-02-01 00:00:00pages
357-64issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00527-4journal_volume
28pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract::The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00068-0
更新日期:1998-01-01 00:00:00
abstract::Obestatin is a recently discovered peptide hormone that appears to be involved in reducing food intake, gut motility and body weight. Obestatin is a product of the preproghrelin gene and appears to oppose several physiological actions of ghrelin. This study investigated the acute effects of obestatin (1-23) and the tr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.02.003
更新日期:2007-05-01 00:00:00
abstract::Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80095-2
更新日期:1981-01-01 00:00:00
abstract::We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.11.034
更新日期:2005-10-01 00:00:00
abstract::Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.032
更新日期:2009-10-01 00:00:00
abstract::The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90024-8
更新日期:1994-01-01 00:00:00
abstract::In lieu of H-Dmt-Tic-OH, H-Dmt-analogues included 2-amino-3(1H-benzoimidazol-2-yl)-propionic acid, N(Bzl)Gly, L-octahydroindole-2-carboxylic acid, [3S-(3alpha,4abeta, 8abeta)]-decahydro-3-isoquinoline carboxylic acid, benzimidazole-, pyridoindole- or spiroinden-derivatives, or C-terminally modified. L- or D-Ala, Sar, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00315-6
更新日期:2000-11-01 00:00:00
abstract::Using the indirect immunofluorescence method, enkephalin-like immunoreactivity was visualized on human fetus spinal cord sections (gestational age from 17 to 25 weeks). Immunolabeled varicose fibers and terminal-like structures were seen through the whole length fetal spinal cord principally in the dorsal gray, in the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90018-6
更新日期:1988-01-01 00:00:00
abstract::GIP receptor knockout mice were shown to be protected from the development of obesity on a high fat diet, suggesting a role of GIP in the development of obesity. In our study we aimed to test the hypothesis if excess of GIP could accelerate development of obesity and to identify GIP gene targets in adipose tissue. The...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.02.011
更新日期:2011-05-01 00:00:00
abstract::Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.04.019
更新日期:2005-12-01 00:00:00
abstract::The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (l...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90063-9
更新日期:1984-01-01 00:00:00
abstract::Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(99)00093-5
更新日期:1999-01-01 00:00:00
abstract::The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90173-2
更新日期:1994-01-01 00:00:00
abstract::Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90144-0
更新日期:1986-11-01 00:00:00
abstract::Amylin is a peptide hormone secreted from the beta cells of the pancreatic islets. Amylin was administered peripherally or centrally following weak or strong training on footshock avoidance conditioning in a T-maze. Under conditions of weak training, amylin improved memory retention in a dose-dependent manner. Under c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90092-h
更新日期:1992-05-01 00:00:00
abstract::Irisin was first identified in skeletal muscle cells, but its precise location has not yet been demonstrated, and there is limited information about irisin protein in other human and rat tissues. The present immunohistochemical study was undertaken to screen skeletal muscle and other tissues for irisin immunoreactivit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.09.014
更新日期:2014-11-01 00:00:00
abstract::We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90072-8
更新日期:1994-01-01 00:00:00
abstract::WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.021
更新日期:2012-11-01 00:00:00
abstract::Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.016
更新日期:2018-03-01 00:00:00
abstract::Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170154
更新日期:2019-12-01 00:00:00
abstract::While neuropeptides of the allatostatin family inhibit in vitro production of juvenile hormone, which modulates aspects of development and reproduction in the cockroach, Diploptera punctata, they are susceptible to inactivation by peptidases in the hemolymph, gut, and bound to internal tissues. Patterns of peptidase c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00149-1
更新日期:1999-01-01 00:00:00
abstract::The aim of our study was to determine whether a meal modifies the antisecretory response induced by PYY and the structural requirements to elicit antisecretory effects of analogue PYY(22-36) for potential antidiarrhea therapy. The variations in short-circuit current (Isc) due to the modification of ionic transport acr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02037-3
更新日期:1995-01-01 00:00:00
abstract::Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear. Urotensin-related peptide (URP) is a paralog of UII in that it contains the six a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.013
更新日期:2008-05-01 00:00:00
abstract::Endocrine tumor cells in culture and in vitro cleavage assays have shown that PC1 and PC2 are capable of processing pro-CCK into smaller, intermediate and final, bioactive forms. Similar studies have shown that PC5 has the ability to process a number of propeptides. Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00451-x
更新日期:2001-08-01 00:00:00
abstract::Prolactin (PRL) is known to exert neuroprotective effects against excitotoxic damage in the hippocampus of female rats, both in vitro and in vivo. It is still unknown whether this effect can be seen in the male hippocampus and intracellular signaling mediating such action. To assess this, adult male CD-1 mice were sub...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170425
更新日期:2021-01-01 00:00:00
abstract::The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.025
更新日期:2008-11-01 00:00:00
abstract::beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.009
更新日期:2006-12-01 00:00:00
abstract::Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.032
更新日期:2012-06-01 00:00:00
abstract::Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90270-5
更新日期:1984-01-01 00:00:00
abstract::Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90116-0
更新日期:1985-05-01 00:00:00