Neuropeptide Y in the recurrent mossy fiber pathway.

Abstract:

:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spontaneously from recurrent mossy fiber terminals, reduces glutamate release from those terminals by activating presynaptic Y2 receptors, and depresses granule cell epileptiform activity dependent on the recurrent pathway. These effects are much greater in rats than in C57BL/6 mice, despite apparently equivalent mossy fiber sprouting and neoexpression of NPY. This species difference can be explained by contrasting changes in the expression of mossy fiber Y2 receptors; seizures upregulate Y2 receptors in rats but downregulate them in mice. The recurrent mossy fiber pathway may synchronize granule cell discharge more effectively in humans and mice than in rats, due to its lower expression of either NPY (humans) or Y2 receptors (mice).

journal_name

Peptides

journal_title

Peptides

authors

Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog H

doi

10.1016/j.peptides.2006.07.026

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

357-64

issue

2

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(06)00527-4

journal_volume

28

pub_type

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