Albuminamide: a novel peptide amide isolated from bovine serum.

abstract：:Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...

journal_title：Peptides

authors： Moreno P,Mantey SA,Lee SH,Ramos-Álvarez I,Moody TW,Jensen RT

更新日期：2018-03-01 00:00:00

abstract：:This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...

journal_title：Peptides

authors： Tao H,Rui C,Zheng J,Tang J,Wu L,Shi A,Chen N,He R,Wu C,Li J,Yin X,Zhang P,Zhu Z,Tao J,Xiao J,Mao C,Xu Z

更新日期：2013-06-01 00:00:00

abstract：:We recently discovered that vascular responsiveness to adrenomedullin (AM), a vasoactive hormone, decreases after hemorrhage, which is markedly improved by the addition of its binding protein AMBP-1. One obstacle hampering the development of AM/AMBP-1 as resuscitation agents in trauma victims is the potential immunoge...

journal_title：Peptides

authors： Wu R,Dong W,Qiang X,Ji Y,Cui T,Yang J,Zhou M,Blau S,Marini CP,Ravikumar TS,Wang P

更新日期：2008-07-01 00:00:00

abstract：:Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...

journal_title：Peptides

authors： Dale CS,Pagano Rde L,Rioli V,Hyslop S,Giorgi R,Ferro ES

更新日期：2005-03-01 00:00:00

abstract：:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...

journal_title：Peptides

authors： Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DH

更新日期：1981-01-01 00:00:00

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation. PACAP also protects cereb...

journal_title：Peptides

authors： Botia B,Basille M,Allais A,Raoult E,Falluel-Morel A,Galas L,Jolivel V,Wurtz O,Komuro H,Fournier A,Vaudry H,Burel D,Gonzalez BJ,Vaudry D

更新日期：2007-09-01 00:00:00

abstract：:Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...

journal_title：Peptides

authors： Huang M,Rorstad OP

更新日期：1987-05-01 00:00:00

abstract：:The pineal nonapeptide hormone arginine vasotocin (AVT) (100 ng/kg) administered intra-nasally (IN) to healthy prepubertal boys, dramatically increased the amount of REM sleep, decreased REM sleep latency, and induced REM periods at sleep onset. Neither arginine vasopressin (AVP) nor oxytocin administered IN at the do...

journal_title：Peptides

authors： Pavel S,Goldstein R,Petrescu M,Popa M

更新日期：1981-10-01 00:00:00

abstract：:The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...

journal_title：Peptides

authors： Yulis CR,Lederis K,Wong KL,Fisher AW

更新日期：1986-01-01 00:00:00

abstract：:The effect of peripheral injections of substance P (SP) on performance in two different configurations of an automated tunnel maze was examined in three experiments. In two experiments, the effect of pretrial SP injections (10-1000 micrograms/kg) on performance in the hexagonal and radial maze configuration of an auto...

journal_title：Peptides

authors： Nagel JA,Welzl H,Bättig K,Huston JP

更新日期：1993-01-01 00:00:00

abstract：:The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...

journal_title：Peptides

authors： Moss RB,Golightly MG

更新日期：1991-07-01 00:00:00

abstract：:Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...

journal_title：Peptides

authors： Bernardes CP,Santos NAG,Sisti FM,Ferreira RS,Santos-Filho NA,Cintra ACO,Cilli EM,Sampaio SV,Santos AC

更新日期：2018-06-01 00:00:00

abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

journal_title：Peptides

authors： Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

更新日期：1995-01-01 00:00:00

abstract：:To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...

journal_title：Peptides

authors： Hartmann A,Dietl T,Krumrey K,Vogl L,Dirlich G,Holsboer F,Heuser-Link M

更新日期：1995-01-01 00:00:00

abstract：:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...

journal_title：Peptides

authors： Reymann KG,Chepkova AN,Matthies H

更新日期：1983-05-01 00:00:00

abstract：:The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100 ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10 microl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200 ng AVP or 1...

journal_title：Peptides

authors： Yang J,Song CY,Liu WY,Lin BC

更新日期：2006-12-01 00:00:00

abstract：:Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord....

journal_title：Peptides

authors： Naftchi NE,Abrahams SJ,St Paul HM,Vacca LL

更新日期：1981-01-01 00:00:00

abstract：:Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...

journal_title：Peptides

authors： Bland ND,Thomas JE,Audsley N,Shirras AD,Turner AJ,Isaac RE

更新日期：2007-01-01 00:00:00

abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

journal_title：Peptides

authors： Shetzline MA,Zipf WB,Nishikawara MT

更新日期：1998-01-01 00:00:00

abstract：:Using the indirect immunofluorescence method, enkephalin-like immunoreactivity was visualized on human fetus spinal cord sections (gestational age from 17 to 25 weeks). Immunolabeled varicose fibers and terminal-like structures were seen through the whole length fetal spinal cord principally in the dorsal gray, in the...

journal_title：Peptides

authors： Rougeot C,Charnay Y,Dray F,Dubois PM

更新日期：1988-01-01 00:00:00

abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...

journal_title：Peptides

authors： Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MA

更新日期：2010-07-01 00:00:00

abstract：:Cholecystokinin (CCK) is widely distributed in the brain and is known to affect behavioral and physiological functions including anxiety and pain. The expression of CCK has been shown to be regulated by estrogen and to vary during the estrous cycle in rat brain. In the present study CCK was determined in plasma from 2...

journal_title：Peptides

authors： Lundberg K,Hilke S,Nordin C,Theodorsson E,Josefsson A

更新日期：2010-08-01 00:00:00

abstract：:Plant sucking heteropteran bugs feed regularly on small amounts of K(+)-rich plant material, in contrast to their hematophagous relatives which imbibe large volumes of Na(+)-rich blood. It was anticipated that this would be reflected in the endocrine control of Malpighian tubule (MT) secretion. To explore this, neuroe...

journal_title：Peptides

authors： Coast GM,TeBrugge VA,Nachman RJ,Lopez J,Aldrich JR,Lange A,Orchard I

更新日期：2010-03-01 00:00:00

abstract：:Galanin has been shown to be present in substantial quantities in the human and rat genitourinary tract by radioimmunoassay and immunocytochemistry. The highest concentrations measured by radioimmunoassay were found in the human vas deferens, corpus cavernosum and spongiosum and in the vagina and cervix. In man gel ch...

journal_title：Peptides

authors： Bauer FE,Christofides ND,Hacker GW,Blank MA,Polak JM,Bloom SR

更新日期：1986-01-01 00:00:00

abstract：:We have evaluated a new immunoradiometric assay (IRMA) for calcitonin (CT) (Medgenix, Belgium). The detection limit of immunoreactive CT (IR-CT) was 2.8 pg/ml, and plasma levels of IR-CT of 134 healthy adults (dynamic range, 2.8-1000 pg/ml) were < 19 pg/ml (median 4.1 pg/ml). Both basal and pentagastrin-stimulated IR-...

journal_title：Peptides

authors： Wimalawansa SJ,Bailey F

更新日期：1995-01-01 00:00:00

abstract：:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...

journal_title：Peptides

authors： Cebrat M,Wieczorek Z,Siemion IZ

更新日期：1996-01-01 00:00:00

abstract：:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...

journal_title：Peptides

authors： Vatta MS,Papouchado ML,Bianciotti LG,Fernandez BE

更新日期：1994-01-01 00:00:00

abstract：:We have previously shown that brief, vena caval infusion of gastrin-releasing peptide1-27 (GRP), delivered shortly (5 min) after the end of the first spontaneous nocturnal meal, significantly prolongs the postprandial intermeal interval (IMI) without affecting the size of the subsequent meal in freely-feeding rats. In...

journal_title：Peptides

authors： Rushing PA,Gibbs J

更新日期：1998-01-01 00:00:00

abstract：:The effects of third ventricular (IVT) injection of 25 micrograms of bradykinin (BK) upon plasma levels of LH, FSH, TSH, GH and prolactin were investigated in conscious ovariectomized female rats bearing indwelling jugular cannulae. Some animals were pretreated with bradykinin potentiating factor (BPF). Intravenous ad...

journal_title：Peptides

authors： Steele MK,Negro-Vilar A,McCann SM

更新日期：1980-10-01 00:00:00