解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is recognized as a surrogate marker of lipid oxidation and is associated with arteriosclerosis. However, there are limited reports on the relationship between heart failure and MDA-LDL. Therefore, we aimed to determine whether MDA-LDL is activated in patients w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170421
更新日期:2021-01-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART aff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170431
更新日期:2021-01-01 00:00:00
abstract::Prolactin (PRL) is known to exert neuroprotective effects against excitotoxic damage in the hippocampus of female rats, both in vitro and in vivo. It is still unknown whether this effect can be seen in the male hippocampus and intracellular signaling mediating such action. To assess this, adult male CD-1 mice were sub...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170425
更新日期:2021-01-01 00:00:00
abstract::During a stress response, various neuropeptides are secreted in a spatiotemporally coordinated way in the brain. For a precise understanding of peptide functions in a stress response, it is important to investigate when and where they are released, how they diffuse, and how they are broken down in the brain. In the pa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170456
更新日期:2020-11-24 00:00:00
abstract::Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170446
更新日期:2020-11-13 00:00:00
abstract::The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170443
更新日期:2020-11-07 00:00:00
abstract::Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-ope...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170386
更新日期:2020-11-01 00:00:00
abstract::Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170351
更新日期:2020-11-01 00:00:00
abstract::The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170352
更新日期:2020-10-01 00:00:00
abstract::Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170366
更新日期:2020-10-01 00:00:00
abstract::Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170369
更新日期:2020-09-01 00:00:00
abstract::A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170353
更新日期:2020-09-01 00:00:00
abstract::An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170328
更新日期:2020-08-01 00:00:00
abstract::CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170309
更新日期:2020-06-01 00:00:00
abstract::Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and the related hormone glucagon-like pepti...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2019.170224
更新日期:2020-03-01 00:00:00
abstract::Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes an...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2019.170203
更新日期:2020-03-01 00:00:00
abstract::Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170195
更新日期:2020-01-01 00:00:00
abstract::Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia. Yet, data on hepcidin status in dementia are scanty, limited to Alzheimer's disease (AD) and inconsistent due to methodological problems with its determination using immunoassays and/or lack of homoge...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170169
更新日期:2019-12-01 00:00:00
abstract::Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170154
更新日期:2019-12-01 00:00:00
abstract::Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...
journal_title:Peptides
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.peptides.2019.170117
更新日期:2019-09-01 00:00:00
abstract::BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170106
更新日期:2019-08-01 00:00:00
abstract::This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of "positive addictive" p...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2019.04.008
更新日期:2019-06-01 00:00:00
abstract::We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2018.12.002
更新日期:2019-02-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.11.006
更新日期:2019-02-01 00:00:00
abstract::Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.06.010
更新日期:2018-09-01 00:00:00
abstract::For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.07.004
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.06.009
更新日期:2018-08-01 00:00:00
abstract::The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.05.004
更新日期:2018-07-01 00:00:00
abstract::Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2018.03.018
更新日期:2018-06-01 00:00:00
abstract::Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.04.012
更新日期:2018-06-01 00:00:00
abstract::Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.03.003
更新日期:2018-05-01 00:00:00
abstract::Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.02.005
更新日期:2018-04-01 00:00:00
abstract::Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.007
更新日期:2018-03-01 00:00:00
abstract::Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.016
更新日期:2018-03-01 00:00:00
abstract::Enzyme-resistant receptor agonists of the incretin hormone glucagon-like peptide-1 (GLP-1) have shown positive therapeutic effects in people with type 2 diabetes mellitus (T2DM). T2DM has detrimental effects on brain function and impairment of cognition and memory formation has been described. One of the underlying me...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2017.11.017
更新日期:2018-02-01 00:00:00
abstract::Combined modulation of peptide hormone receptors including, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established benefits for the treatment of diabetes. The present study has assessed the biological actions and therapeutic efficacy of a novel exendin-4/xenin-8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.10.015
更新日期:2018-02-01 00:00:00
abstract::Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2017.11.016
更新日期:2018-02-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH as the only neuropeptide, while others comprise cocaine- and amphetamine regula...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.11.002
更新日期:2018-01-01 00:00:00