Abstract:
:Structurally unique, synthetic prion peptides provide the basis of a simple assay to serve as both a detection and signal amplification system that distinguishes the normal prion protein, PrPC, from the misfolded prion protein, PrPSc, that is associated with the occurrence of transmissible spongiform encephalopathies (TSE). Proof-of-principle has been shown on brain samples from an experimental scrapie hamster model. The assay demonstrates very sensitive detection of PrPSc in animal brain tissue with potential application for early presymptomatic detection in animal screening. Furthermore, the sensitivity of the assay could enable blood tests for this TSE disease as well as other amyloid and/or misfolded protein diseases.
journal_name
Peptidesjournal_title
Peptidesauthors
Grosset A,Moskowitz K,Nelsen C,Pan T,Davidson E,Orser CSdoi
10.1016/j.peptides.2005.03.006subject
Has Abstractpub_date
2005-11-01 00:00:00pages
2193-200issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00118-Xjournal_volume
26pub_type
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