Abstract:
:The pineal nonapeptide hormone arginine vasotocin (AVT) (100 ng/kg) administered intra-nasally (IN) to healthy prepubertal boys, dramatically increased the amount of REM sleep, decreased REM sleep latency, and induced REM periods at sleep onset. Neither arginine vasopressin (AVP) nor oxytocin administered IN at the dose of 100 ng/kg was able to reproduce the effects of AVT, demonstrating its high specificity. Methergoline, a selective central 5-hydroxytryptamine (5-HT) receptor blocker, administered IN at the dose of 100 ng/kg, completely prevented AVT induction of REM sleep. Fluoxetine, a specific 5-HT uptake inhibitor, administered IN at the dose of 25 microgram/kg, 10 min after AVT, greatly potentiated the effects of AVT in inducing REM periods at sleep onset and in increasing the amount of REM sleep and the percentage of dream reports. It is suggested that AVT induces REM sleep in prepubertal boys by interfering with 5-HT neurotransmission and that the high sensitivity of prepubertal boys to AVT reflects an immaturity of REM triggering centers.
journal_name
Peptidesjournal_title
Peptidesauthors
Pavel S,Goldstein R,Petrescu M,Popa Mdoi
10.1016/s0196-9781(81)80113-1subject
Has Abstractpub_date
1981-10-01 00:00:00pages
245-50issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(81)80113-1journal_volume
2pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.08.004
更新日期:2017-10-01 00:00:00
abstract::The effect of vasoactive intestinal peptide (VIP) on the nerve-stimulated contraction, tissue oxygenation, lipid peroxidation and antioxidant enzymes activities-superoxide dismutase and catalase was investigated in the rat gastrocnemius muscle exposed to 4 h ischemia-4hr reperfusion. Ischemia caused significant decrea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00289-6
更新日期:1997-01-01 00:00:00
abstract::Plasmodium falciparum malaria parasite invasion of erythrocytes is an essential step in host infection and the proteins involved in such invasion are the main target in developing an antimalarial vaccine. Secretory organelle-derived proteins (micronemal AMA1 protein and the RON2, 4, and 5 rhoptry neck proteins) have b...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.07.028
更新日期:2014-03-01 00:00:00
abstract::The degradation of synthetic Manduca sexta allatostatin (Manse-AS) and allatotropin (Manse-AT), by enzymes of the foregut of larvae of the tomato moth, Lacanobia oleracea was investigated using reversed-phase high performance liquid chromatography (RP-HPLC) together with matrix-assisted laser desorption ionization-tim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00189-4
更新日期:2002-11-01 00:00:00
abstract::As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.06.008
更新日期:2017-08-01 00:00:00
abstract::Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.10.026
更新日期:2005-03-01 00:00:00
abstract::The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...
journal_title:Peptides
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.peptides.2007.02.004
更新日期:2007-05-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.11.006
更新日期:2019-02-01 00:00:00
abstract::Plant defensins are a prominent family of cationic peptides in the plant kingdom. They are structurally and functionally related to defensins that have been previously characterized in mammals and insects. They present molecular masses between 5 and 7kDa and possess a pattern of eight conserved Cys residues. The three...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.01.018
更新日期:2009-05-01 00:00:00
abstract::Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.09.002
更新日期:2015-11-01 00:00:00
abstract::The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.01.027
更新日期:2009-05-01 00:00:00
abstract::The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.005
更新日期:2012-11-01 00:00:00
abstract::The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.031
更新日期:2007-02-01 00:00:00
abstract::Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.01.015
更新日期:2016-04-01 00:00:00
abstract::STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned S...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.015
更新日期:2005-01-01 00:00:00
abstract::alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80026-5
更新日期:1981-07-01 00:00:00
abstract::In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00108-4
更新日期:1999-01-01 00:00:00
abstract::We report herein the isolation and characterization of a novel glycine-rich antimicrobial peptide purified from the larvae of Drosophila virilis. A range of chromatographic methods was used for isolation and its antibacterial activity against Bacillus subtilis was employed to screen for the most active fractions. The ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.09.028
更新日期:2010-01-01 00:00:00
abstract::Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.022
更新日期:2005-12-01 00:00:00
abstract::The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.029
更新日期:2011-08-01 00:00:00
abstract::The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90184-7
更新日期:1990-07-01 00:00:00
abstract::This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfact...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.031
更新日期:2012-06-01 00:00:00
abstract::Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.11.005
更新日期:2010-04-01 00:00:00
abstract::The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90145-f
更新日期:1991-07-01 00:00:00
abstract::Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00581-2
更新日期:2002-01-01 00:00:00
abstract::Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90196-8
更新日期:1986-01-01 00:00:00
abstract::Epithelial to mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells transition to a mesenchymal phenotype, has been implicated in the pathogenesis of renal fibrosis. Apelin, a bioactive peptide, has recently been recognized to protect against renal profibrotic activity, but the underlyi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.08.006
更新日期:2017-10-01 00:00:00
abstract::Food deprivation inhibits estrous behavior in several species of rodents, but little is known about the neurotransmitter systems mediating this phenomenon. We determined whether partial blockade of opioid receptors by continuous infusion of naltrexone and/or acute peripheral injection of cholecystokinin (CCK) administ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00370-9
更新日期:2001-04-01 00:00:00
abstract::Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00264-3
更新日期:2000-08-01 00:00:00
abstract::Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90061-0
更新日期:1985-03-01 00:00:00