Abstract:
:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of OXT, its mechanism has not been well elucidated. Recently, it has been also hypothesize that OXT, increasing intracellular concentration of calcium, could regulate the production of mediators, like endocannabinoids (eCB). It has been well documented that eCB are able to suppress pain pathways. The present study investigates the effect of OXT in paw carrageenan-induced pain. Intracerebroventricular (icv) administration of OXT, but neither intraperitoneal nor intraplantar route, induces an antihyperalgesic effect increasing paw withdrawal latency to mechanical or thermal stimuli. Our results clearly demonstrate that 3 and 6h following carrageenan challenge, central administration of OXT (30 ng/mouse) shows a significant antihyperalgesic activity. Moreover, for the first time, we demonstrate that CB1 receptor plays a key role in the antihyperalgesic effect of OXT. In fact our results show CB1 antagonist, but not the specific CB2 antagonist reduce OXT-induced antihyperalgesic effect. In addition, our data show that central OXT administration is able to reduce carrageenan-induced hyperalgesia but does not modify carrageenan-induced paw edema. Finally, using opioid antagonists we confirm an important role of opioid receptors. In conclusion, our experiments suggest that central administration of OXT reduces hyperalgesia induced by intraplantar injection of carrageenan, and this effect may work via cannabinoid and opioid systems.
journal_name
Peptidesjournal_title
Peptidesauthors
Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano Adoi
10.1016/j.peptides.2012.08.005subject
Has Abstractpub_date
2012-11-01 00:00:00pages
81-8issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00355-5journal_volume
38pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattere...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90126-8
更新日期:1984-09-01 00:00:00
abstract::Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.005
更新日期:2004-11-01 00:00:00
abstract::Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Dist...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.07.002
更新日期:2003-08-01 00:00:00
abstract::N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00225-8
更新日期:1997-01-01 00:00:00
abstract::In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90165-2
更新日期:1990-11-01 00:00:00
abstract::To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90152-u
更新日期:1990-11-01 00:00:00
abstract::In experimental models and in humans, somatostatin (SRIF) is able to contract certain vascular structures. The present experiments were designed to assess the capacity of SRIF to contract cultured rat aortic vascular smooth muscle cells (VSMC), and to analyze the possible mechanisms involved. Cells incubated with SRIF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00083-2
更新日期:1999-01-01 00:00:00
abstract::A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00355-2
更新日期:2001-03-01 00:00:00
abstract::C-type natriuretic peptide (CNP) was recently found in myocardium at the mRNA and protein levels, but it is not known whether cardiomyocytes are able to produce CNP. The aim of this study was to determine the expression of CNP and its specific receptor NPR-B in cardiac cells, both in vitro and ex vivo. CNP, brain natr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.06.014
更新日期:2011-08-01 00:00:00
abstract::The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCKA receptor antagoni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00247-1
更新日期:1997-01-01 00:00:00
abstract::Instability and proteolytic degradation limit the delivery options and in vivo efficacy of many therapeutic peptides. We previously generated a thioether stabilized angiotensin-(1-7) analog, cAng-(1-7), which is resistant against proteolytic degradation in the circulation. We here investigated oral and pulmonary deliv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.02.015
更新日期:2010-05-01 00:00:00
abstract::Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(02)00269-3
更新日期:2002-12-01 00:00:00
abstract::Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90037-6
更新日期:1980-04-01 00:00:00
abstract::Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patient...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.05.003
更新日期:2013-08-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART aff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170431
更新日期:2021-01-01 00:00:00
abstract::The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170352
更新日期:2020-10-01 00:00:00
abstract::Receptor binding analysis was performed in the renal medulla from 2-month-old rats, an extrapituitary tissue containing the highest level of GHRH receptor mRNA. At 4 degrees C, in the presence of a cocktail of protease inhibitors, binding of [125I-Tyr(10)]hGHRH (1-44)NH(2) to medullary homogenates was specific, time-d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00029-3
更新日期:2002-06-01 00:00:00
abstract::Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00374-0
更新日期:2001-02-01 00:00:00
abstract::Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(02)00069-4
更新日期:2002-07-01 00:00:00
abstract::The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.06.009
更新日期:2017-09-01 00:00:00
abstract::Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90103-c
更新日期:1990-01-01 00:00:00
abstract::Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides lowered blood pressure of spontaneously hypertensive rats (SHR)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00174-8
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). METHODS:Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anestheti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.04.008
更新日期:2010-07-01 00:00:00
abstract::Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin. These results suggest that caudate nucleus plays an inhibitory role in controlling the cataleptic response...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90368-7
更新日期:1985-01-01 00:00:00
abstract::Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90013-1
更新日期:1987-05-01 00:00:00
abstract::Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.022
更新日期:2012-12-01 00:00:00
abstract::The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.02.005
更新日期:2018-04-01 00:00:00
abstract::Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90101-2
更新日期:1982-05-01 00:00:00
abstract::The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90014-3
更新日期:1987-05-01 00:00:00
abstract::A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.06.004
更新日期:2004-08-01 00:00:00