Abstract:
:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions and pathophysiological roles of NPs in a wide range of diseases including hypertension and heart failure. These studies revealed that ANP and BNP are hormones secreted from the heart into the blood stream in response to pre- or after-load, counteracting blood pressure (BP) elevation and fluid retention through specific receptors. Meanwhile, CNP was found to be produced by the vascular endothelium, acting as a local mediator potentially serving protective functions for the blood vessels. Because NPs not only exert blood pressure lowering actions but also alleviate hypertensive organ damage, attempts have been made to develop therapeutic agents for hypertension by utilizing this family of NPs. One strategy is to inhibit neprilysin, an enzyme degrading NPs, thereby enhancing the actions of endogenous peptides. Recently, a dual inhibitor of angiotensin receptor-neprilysin was approved for heart failure, and neprilysin inhibition has also been shown to be beneficial in treating patients with hypertension. This review summarizes the roles of NPs in regulating BP, with special references to hypertension and hypertensive organ damage, and discusses the therapeutic implications of neprilysin inhibition.
journal_name
Peptidesjournal_title
Peptidesauthors
Kato Jdoi
10.1016/j.peptides.2020.170352subject
Has Abstractpub_date
2020-10-01 00:00:00pages
170352eissn
0196-9781issn
1873-5169pii
S0196-9781(20)30101-7journal_volume
132pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract::Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.010
更新日期:2013-05-01 00:00:00
abstract::The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90109-5
更新日期:1989-07-01 00:00:00
abstract::Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90057-8
更新日期:1983-07-01 00:00:00
abstract::The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.02.016
更新日期:2009-06-01 00:00:00
abstract::The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00020-k
更新日期:1995-01-01 00:00:00
abstract::While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90216-0
更新日期:1986-03-01 00:00:00
abstract::WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.021
更新日期:2012-11-01 00:00:00
abstract::Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80095-2
更新日期:1981-01-01 00:00:00
abstract::Insect flight requires rapid mobilization of energy reserves during flight, which is mediated and regulated by hormonal control via adipokinetic hormones. The structure of the G-protein receptors to which these hormones bind, are crucial in understanding many of the physiological processes in which they play a central...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.08.017
更新日期:2011-03-01 00:00:00
abstract::Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.019
更新日期:2008-11-01 00:00:00
abstract::Binding of [125I]PACAP-38 to rat liver membranes was investigated. It was rapid at 37 degrees C, reversible, and saturable, and it was time, concentration, and temperature dependent. Scatchard plots showed that [125I]PACAP-38 bound to single noninteracting site(s), and [125I]VIP bound to high- and low-affinity binding...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90206-2
更新日期:1994-01-01 00:00:00
abstract::A novel protein expressed by entero-endocrine cells of the mouse stomach was named prepromotilin Related Peptide (ppMTLRP) since it shares sequence similarities with the prepromotilin (Tomasetto et al.). The mouse ppMTLRP was found identical to the rat precursor of ghrelin (ppghrelin), an endogenous ligand specific fo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00557-5
更新日期:2001-12-01 00:00:00
abstract::The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum diluti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90047-7
更新日期:1994-01-01 00:00:00
abstract::GIP receptor knockout mice were shown to be protected from the development of obesity on a high fat diet, suggesting a role of GIP in the development of obesity. In our study we aimed to test the hypothesis if excess of GIP could accelerate development of obesity and to identify GIP gene targets in adipose tissue. The...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.02.011
更新日期:2011-05-01 00:00:00
abstract::The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.007
更新日期:2006-04-01 00:00:00
abstract::A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90247-x
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). METHODS:Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anestheti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.04.008
更新日期:2010-07-01 00:00:00
abstract::A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.06.022
更新日期:2011-08-01 00:00:00
abstract::[3H]Neurotensin (NT) was found to bind specifically and with high affinity to crude membranes prepared from rat uterus. Scatchard analysis of saturation binding studies indicated that [3H]NT apparently binds to two sites (high affinity Kd 0.5 nM; low affinity Kd 9 nM) with the density of high affinity sites (41 fmoles...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90149-5
更新日期:1987-11-01 00:00:00
abstract::Higher levels of natriuretic peptides were identified in outpatients after myocardial infarction (MI) compared to the healthy population, even in the absence of heart failure (HF). Therefore, we assessed the optimal cut-off value of B-type natriuretic peptide (BNP) in relation to new-onset HF prediction in 79 post-MI ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.023
更新日期:2010-10-01 00:00:00
abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.017
更新日期:2008-06-01 00:00:00
abstract::The RPCH and beta-actin cDNAs from the crayfish Cherax quadricarinatus were amplified, cloned and sequenced. The primary structure sequences of these cDNAs were compared to other members of the AKH/RPCH family. Fluctuations in the amount of the C. quadricarinatus RPCH and beta-actin mRNAs, as cDNAs, were quantified ev...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.018
更新日期:2005-12-01 00:00:00
abstract::The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90184-7
更新日期:1990-07-01 00:00:00
abstract::Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90166-4
更新日期:1985-07-01 00:00:00
abstract::The intestinal enzymatic degradation of the immunomodulating peptides thymotrinan (TP3), thymocartin (TP4), and thymopentin (TP5), three oligopeptides derived from the naturally occurring thymus hormone thymopoietin, was investigated to evaluate their potential for peroral drug delivery. In the presence of brush-borde...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00178-7
更新日期:1996-01-01 00:00:00
abstract::Japonicin-1 (FFPIGVFCKIFKTC) and japonicin-2 (FGLPMLSILPKALCILLKRKC), two peptides with differential growth-inhibitory activity against the Gram-negative bacterium, Escherichia coli and the Gram-positive bacterium Staphylococcus aureus, were isolated from an extract of the skin of the Japanese brown frog Rana japonica...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00634-9
更新日期:2002-03-01 00:00:00
abstract::Besides its well known endocrinological effects, thyrotropin-releasing hormone (TRH) has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders. The aim of this study was to assess if transdermal delivery of TRH and its analogue, M-TRH, in the presence of enhancers, i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00358-2
更新日期:2001-01-01 00:00:00
abstract::In the Nucleus Ambiguus (NA) mu-receptors increased mean arterial pressure (MAP) and heart rate (HR) and kappa-receptors decreased MAP without altering HR. Mu-receptors in the Dorsal Motor Nucleus of the Vagus (DMV) increased MAP without changing HR whereas kappa-receptors in the DMV decreased HR without changing MAP....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90225-2
更新日期:1988-01-01 00:00:00
abstract::This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00155-2
更新日期:1999-12-01 00:00:00
abstract::Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.03.028
更新日期:2015-09-01 00:00:00