Abstract：
:GIP receptor knockout mice were shown to be protected from the development of obesity on a high fat diet, suggesting a role of GIP in the development of obesity. In our study we aimed to test the hypothesis if excess of GIP could accelerate development of obesity and to identify GIP gene targets in adipose tissue. Therefore, mice were kept on a chow or a high fat diet and during the last 2 weeks D-Ala(2)-GIP or PBS injections were performed. Afterwards, serum LPL activity and several biochemical parameters (TG, FFA, cholesterol, glucose, insulin, resistin, IL-6, IL-1β, TNFα, GIP) were measured. Fat tissue was isolated and QPCR was performed for a set of genes involved in energy metabolism and inflammation. A DNA-microarray was used to identify GIP gene targets in adipose tissue of the chow diet group. We found that the D-Ala(2)-GIP injections caused a significant decrease in both body weight and LPL activity compared to controls. Serum biochemical parameters were not affected by D-Ala(2)-GIP, with an exception for resistin and insulin. The set of inflammatory genes were significantly decreased in adipose tissue in the D-Ala(2)-GIP injected animals on a chow diet. A DNA-microarray revealed that APO-genes and CYP-genes were affected by D-Ala(2)-GIP treatment in adipose tissue. These results suggest that the body weight-reducing effect of D-Ala(2)-GIP may be explained by lower LPL activity and insulin serum level. Moreover, the identified GIP candidate gene targets in adipose tissue link GIP action to lipid metabolism exerted by APO and CYP genes.
journal_name
Peptidesjournal_title
Peptidesauthors
Szalowska E,Meijer K,Kloosterhuis N,Razaee F,Priebe M,Vonk RJdoi
10.1016/j.peptides.2011.02.011subject
Has Abstractpub_date
2011-05-01 00:00:00pages
938-45issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(11)00080-5journal_volume
32pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Mate attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, and temptin which are released during egg-laying. Other water-borne pheromones are predicted to act in concert with attractin, enticin, and temptin, but their identities were unknown. We recently identified a highl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.10.024
更新日期：2005-03-01 00:00:00
abstract：:Various growth factors and their receptors are present in the nervous system. This review focuses on the presence of epidermal growth factor (EGF) and its receptors in the central nervous system (CNS). Evidence indicates that EGF in the CNS is the result of local synthesis, by intrinsic and blood-derived macrophages, ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(91)90115-6
更新日期：1991-05-01 00:00:00
abstract：:Nesfatin-1 is well established to reduce food intake upon brain injection in rats, while in mice its anorexigenic action and brain expression are largely unexplored. We characterized the influence of intracerebroventricular (icv) and peripheral (intraperitoneal, ip, subcutaneous, sc) injection of nesfatin-1 on dark ph...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.09.027
更新日期：2011-01-01 00:00:00
abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.07.005
更新日期：2012-09-01 00:00:00
abstract：:Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes an...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2019.170203
更新日期：2020-03-01 00:00:00
abstract：:Thirty viral proteomes were examined for amino acid sequence similarity to the human proteome, and, in parallel, a control of 30 sets of human proteins was analyzed for internal human overlapping. We find that all of the analyzed 30 viral proteomes, independently of their structural or pathogenic characteristics, pres...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.05.022
更新日期：2008-10-01 00:00:00
abstract：:An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.06.028
更新日期：2007-08-01 00:00:00
abstract：:The anorectic effect of IP injection of amylin (1 microgram/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 micrograms/kg]. The IP injection of pancreatic glucagon (400 micrograms/kg) at dark onset also reduced food intake in 24-h ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02046-2
更新日期：1996-01-01 00:00:00
abstract：:Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00044-5
更新日期：2003-02-01 00:00:00
abstract：:A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90247-x
更新日期：1984-03-01 00:00:00
abstract：:To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to h...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00149-0
更新日期：1996-01-01 00:00:00
abstract：:Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90019-0
更新日期：1983-09-01 00:00:00
abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90047-s
更新日期：1991-09-01 00:00:00
abstract：:In non-pregnant goats, ovariectomy on day 12 of oestrous cycle resulted in parallel decrease of oxytocin and progesterone jugular concentration. Similarly, luteolysis, indicated by decreasing progesterone concentration, was accompanied by simultaneous release of oxytocin and oxytocin-associated neurophysins (mean of n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90063-5
更新日期：1987-09-01 00:00:00
abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:Incorporation of N-succinimidyl-3(4-hydroxyphenyl) propionate (Bolton-Hunter reagent) or its 125I-labeled derivative into peptides can be selectively directed towards either alpha- or epsilon-amine functions by modifying the pH of the reaction. Acylation of alpha-amino groups is favored at pH 6.5 whereas epsilon-amino...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90027-z
更新日期：1992-11-01 00:00:00
abstract：:Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90140-9
更新日期：1987-11-01 00:00:00
abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90014-3
更新日期：1987-05-01 00:00:00
abstract：:Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90249-5
更新日期：1988-01-01 00:00:00
abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.03.021
更新日期：2012-03-01 00:00:00
abstract：:Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90170-7
更新日期：1987-01-01 00:00:00
abstract：:We studied the expression of the osteogenic and antinociceptive C-terminal histone H4-related peptide fragments, H4-(89-102) (OGP) and H4-(86-100), respectively, within various rat tissues and isolated alveolar macrophages (AM) by radioimmunoassay (RIA). OGP was located mainly within the bone marrow, spleen, thymus, a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.03.013
更新日期：2005-08-01 00:00:00
abstract：:Pituitary cells from 14-day-old rats were separated by unit gravity velocity sedimentation, and a highly enriched population of gonadotrophs was established in reaggregate cell culture in serum-free and serum albumin-free defined culture media. The medium conditioned by these aggregates was concentrated, ultrafiltrate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90217-8
更新日期：1994-01-01 00:00:00
abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2005.02.002
更新日期：2005-09-01 00:00:00
abstract：:In this study, an amphibian (Odorrana hejiangensis) skin extract was fractionated by reverse phase HPLC and fractions were screened for trypsin inhibitory activity. Using this initial approach, a novel trypsin inhibitory peptide was detected with an apparent protonated molecular mass of 1804.83 Da, as determined by MA...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.01.003
更新日期：2012-02-01 00:00:00
abstract：:Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.005
更新日期：2010-04-01 00:00:00
abstract：:The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90095-7
更新日期：1991-05-01 00:00:00
abstract：:The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90008-0
更新日期：1982-09-01 00:00:00
abstract：:Atrial natriuretic peptide (ANP) is increasingly expressed on airway and inhibits pulmonary arterial remodeling. However, the role of ANP in remodeling of respiratory system is still unclear. The role of ANP on airway remodeling and the possible mechanism was explored in this study. Both human bronchial epithelial 16H...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2017.02.002
更新日期：2017-04-01 00:00:00
abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.012
更新日期：2010-11-01 00:00:00
