Abstract：
:Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes and promotion of fat deposition in tissues. As such, blockade of GIP receptor (GIPR) action has been proposed as a means to counter insulin resistance, and improve metabolic status in obesity and related diabetes. In agreement with this, numerous independent observations in animal models support important therapeutic applications of GIPR antagonists in obesity-diabetes. Sustained administration of peptide-based GIPR inhibitors, low molecular weight GIPR antagonists, GIPR neutralising antibodies as well as genetic knockout of GIPR's or vaccination against GIP all demonstrate amelioration of insulin resistance and reduced body weight gain in response to high fat feeding. These observations were consistently associated with decreased accumulation of lipids in peripheral tissues, thereby alleviating insulin resistance. Although the impact of prolonged GIPR inhibition on bone turnover still needs to be determined, evidence to date indicates that GIPR antagonists represent an exciting novel treatment option for obesity-diabetes.
journal_name
Peptidesjournal_title
Peptidesauthors
Irwin N,Gault VA,O'Harte FPM,Flatt PRdoi
10.1016/j.peptides.2019.170203subject
Has Abstractpub_date
2020-03-01 00:00:00pages
170203eissn
0196-9781issn
1873-5169pii
S0196-9781(19)30181-0journal_volume
125pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract：:The pineal nonapeptide hormone arginine vasotocin (AVT) (100 ng/kg) administered intra-nasally (IN) to healthy prepubertal boys, dramatically increased the amount of REM sleep, decreased REM sleep latency, and induced REM periods at sleep onset. Neither arginine vasopressin (AVP) nor oxytocin administered IN at the do...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80113-1
更新日期：1981-10-01 00:00:00
abstract：:Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.05.019
更新日期：2013-03-01 00:00:00
abstract：:The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.02.005
更新日期：2018-04-01 00:00:00
abstract：:This mass spectrometric study confines itself to peptide masses in the range of 500-1500Da. Adipokinetic hormones (AKHs) that are predicted from the genome of the red flour beetle, Tribolium castaneum, and the silk moth, Bombyx mori, are shown to exist as expressed peptides in the corpora cardiaca (CC) of the respecti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.03.002
更新日期：2008-07-01 00:00:00
abstract：:This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in controlling autoimmune diseases or inducing immunotolerance. ICAM-1/LFA-1 interaction is essential for T-cell activation as well as for migration of T-cells to targe...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(03)00083-4
更新日期：2003-03-01 00:00:00
abstract：:Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90171-x
更新日期：1992-07-01 00:00:00
abstract：:The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90151-e
更新日期：1991-07-01 00:00:00
abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90009-2
更新日期：1982-09-01 00:00:00
abstract：:The present study sought to examine the mechanism of substance P to modulate the antinociceptive action of intrathecal (i.t.) morphine in paw-licking/biting response evoked by subcutaneous injection of capsaicin into the plantar surface of the hindpaw in mice. The i.t. injection of morphine inhibited capsaicin-induced...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.06.002
更新日期：2009-09-01 00:00:00
abstract：:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90184-7
更新日期：1990-07-01 00:00:00
abstract：:Numerous substance P (SP) immunoreactive nerve fibers were located around submucosal glands in the guinea pig nasal mucosa. Since these SP positive nerve fibers were also positive for vasoactive intestinal polypeptide, and to a lessor extent for neuropeptide Y, they were presumed to be parasympathetic fibers. SP recep...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00100-4
更新日期：1998-01-01 00:00:00
abstract：:Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppres...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90046-4
更新日期：1985-03-01 00:00:00
abstract：:Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.003
更新日期：2012-11-01 00:00:00
abstract：:Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.07.004
更新日期：2014-09-01 00:00:00
abstract：:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.03.013
更新日期：2012-05-01 00:00:00
abstract：:DDSDEEN chromatin peptide, after dansylation, was studied for its ability to bind N-CAM protein. The binding causes a quenching of the Dns-peptide fluorescence emission. Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown. Fluorescence quenching is completely lost if the Dns-peptide is subjected ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.09.008
更新日期：2008-12-01 00:00:00
abstract：:Plasmodium falciparum malaria parasite invasion of erythrocytes is an essential step in host infection and the proteins involved in such invasion are the main target in developing an antimalarial vaccine. Secretory organelle-derived proteins (micronemal AMA1 protein and the RON2, 4, and 5 rhoptry neck proteins) have b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.028
更新日期：2014-03-01 00:00:00
abstract：:We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.10.002
更新日期：2017-12-01 00:00:00
abstract：:In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90409-7
更新日期：1985-01-01 00:00:00
abstract：:We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(81)90050-4
更新日期：1981-01-01 00:00:00
abstract：:This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfact...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.03.031
更新日期：2012-06-01 00:00:00
abstract：:To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00016-5
更新日期：2002-05-01 00:00:00
abstract：:Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.10.014
更新日期：2011-01-01 00:00:00
abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2012.05.015
更新日期：2012-08-01 00:00:00
abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.07.034
更新日期：2008-02-01 00:00:00
abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90150-2
更新日期：1992-01-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.01.014
更新日期：2012-02-01 00:00:00
abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.07.005
更新日期：2004-11-01 00:00:00
abstract：:The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90175-1
更新日期：1988-05-01 00:00:00
abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90061-0
更新日期：1985-03-01 00:00:00
