Abstract:
:Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic and chronotropic effect. Both effects were completely abolished in atria derived from capsaicin-treated guinea pigs. The positive inotropic and chronotropic effects of NT in guinea pig atria were mimicked by capsaicin and calcitonin gene-related peptide (CGRP). These results were interpreted as an indication that NT produces its cardiovascular effects in guinea pigs by activating capsaicin-sensitive sensory neurons.
journal_name
Peptidesjournal_title
Peptidesauthors
Bachelard H,St-Pierre S,Rioux Fdoi
10.1016/0196-9781(87)90140-9subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1079-87issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(87)90140-9journal_volume
8pub_type
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