Abstract：
:Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another peptide that potently reduces food intake in rats, had similar effects on OT secretion and gastric emptying. Although BBS produces a dose-dependent inhibition of food intake, even very high doses did not significantly affect plasma OT levels and only slightly decreased rates of gastric emptying. Consequently, despite their similar inhibitory effects on food intake, BBS does not appear to activate the same network of central nervous system pathways as does CCK in rats. However, parallel studies in monkeys demonstrated that systemic injection of BBS was effective in stimulating neurohypophyseal secretion of vasopressin rather than OT, in a pattern both qualitatively and quantitatively analogous to the effects of CCK in this species. Together with previous findings that BBS more potently inhibits gastric emptying in primates than in rats, these results therefore also suggest the presence of significant species differences in the central mechanisms by which BBS acts to reduce food intake.
journal_name
Peptidesjournal_title
Peptidesauthors
Verbalis JG,McCann MJ,Stricker EMdoi
10.1016/0196-9781(88)90194-5subject
Has Abstractpub_date
1988-11-01 00:00:00pages
1289-93issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(88)90194-5journal_volume
9pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90166-4
更新日期：1985-07-01 00:00:00
abstract：:The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.02.007
更新日期：2013-05-01 00:00:00
abstract：:A new CCK8 related peptide, Boc[Nle28,Nle31]CCK27-33 (Boc[diNle]CCK7) was synthesized and tested for cholecystokinic activity, at both the peripheral and the central level. This analogue, protected against both chemical oxidation and enzymatic degradation by aminopeptidases, was shown to be equipotent to CCK8 in relea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90106-8
更新日期：1985-05-01 00:00:00
abstract：:Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.031
更新日期：2014-03-01 00:00:00
abstract：:We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00166-9
更新日期：1995-01-01 00:00:00
abstract：:Mate attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, and temptin which are released during egg-laying. Other water-borne pheromones are predicted to act in concert with attractin, enticin, and temptin, but their identities were unknown. We recently identified a highl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.10.024
更新日期：2005-03-01 00:00:00
abstract：:A method has been developed for the study of somatostatin (SS) binding to dissociated cells from rat cerebral cortex. Binding of [125I] [Tyr11]SS to cells obtained by mechanical dissociation of rat cerebral cortex was dependent on time and temperature, saturable, reversible and highly specific. Under conditions of equ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90138-u
更新日期：1990-11-01 00:00:00
abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90145-9
更新日期：1989-05-01 00:00:00
abstract：:A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.09.008
更新日期：2007-11-01 00:00:00
abstract：:In sheep, arginine vasopressin (AVP) and corticotropin-releasing factor (CRF) stimulate adrenocorticotropic hormone (ACTH) secretion. Increased hypothalamic secretion of these peptides at the end of gestation initiates parturition in this species. We hypothesized that CRF and/or AVP content in the fetal hypothalamus i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02060-8
更新日期：1996-01-01 00:00:00
abstract：:The corpora cardiaca (CC) of two water bug species, the water boatman Corixa punctata and the saucer bug Ilyocoris cimicoides, contain a substance that cause hyperlipemia in the migratory locust. The primary sequence of one octapeptide belonging to the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.11.019
更新日期：2007-03-01 00:00:00
abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90146-t
更新日期：1992-01-01 00:00:00
abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90037-6
更新日期：1980-04-01 00:00:00
abstract：:We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.10.002
更新日期：2017-12-01 00:00:00
abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00164-5
更新日期：2003-06-01 00:00:00
abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00077-3
更新日期：2002-08-01 00:00:00
abstract：:Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00374-0
更新日期：2001-02-01 00:00:00
abstract：:The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90151-e
更新日期：1991-07-01 00:00:00
abstract：:The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.11.007
更新日期：2011-02-01 00:00:00
abstract：:Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2005.01.023
更新日期：2005-10-01 00:00:00
abstract：:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90057-8
更新日期：1983-07-01 00:00:00
abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.009
更新日期：2010-02-01 00:00:00
abstract：:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Mus...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90059-0
更新日期：1994-01-01 00:00:00
abstract：:Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00190-3
更新日期：1997-01-01 00:00:00
abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.11.013
更新日期：2006-06-01 00:00:00
abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00122-9
更新日期：1999-01-01 00:00:00
abstract：:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90153-8
更新日期：1994-01-01 00:00:00
abstract：:VIP was given intravenously over 1 min at the doses 0.1 and 0.2 micrograms X kg X min-1 to twenty-one anesthetized patients undergoing abdominal surgery. Intra-arterial blood pressure was monitored and various blood flows were measured simultaneously by electromagnetic technique. Following VIP, intra-arterial blood pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90227-4
更新日期：1984-03-01 00:00:00
abstract：:Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02003-f
更新日期：1995-01-01 00:00:00
